XENE — Xenon Pharmaceuticals Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates XENE Bullish with a Setup Score of 32, net conviction 37, actionability 28. How the Setup Score works →

Total Setup Score32
Directional BiasBullish
Net Conviction37
Actionability28 (in range)

Key signals behind this score

About Xenon Pharmaceuticals Inc

Xenon Pharmaceuticals Inc., a neuroscience-focused biopharmaceutical company, engages in the discovery, development, and delivery of therapeutics to treat patients with neurological and psychiatric disorders. Its product candidates include Azetukalner, a novel, potent Kv7 potassium channel opener which is in Phase 3 clinical development for the treatment of epilepsy, including focal onset seizures, and primary generalized tonic-clonic seizures, a… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$63.79
Market Cap$5.78B
Float90.9M
Shares Outstanding96.8M
Price/Sales (TTM)727.44
vs. Analyst Target+27.4% to analyst PT
Dividend RateNone
Analyst Target Price$81.30 (19 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $32.2M -$28.8M $32.2M -$30.7M
2021 $18.4M -$78.9M $18.4M -$78.1M
2022 $9.4M -$125M $9.4M -$128M
2023 N/A -$182M -$168M -$211M
2024 N/A -$234M -$2.6M -$236M
2025 $7.5M -$346M $5.0M -$342M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 N/A -$90.9M
Dec 2025 N/A -$105M
Mar 2026 N/A -$102M
Jun 2026 N/A -$111M

Ownership & Float

Insider Ownership0.1%
Institutional Ownership107.6%
Short Float5.9%
% of All Funds Holding3.58%
Number of Funds Holding315

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$63.62Near-term / short-term trend
Weekly40-Week SMA$52.65Medium-term trend
Weekly80-Week SMA$44.12Cyclical trend (business cycle)
Weekly200-Week SMA$41.29Secular trend (multi-year)
Monthly10-Month SMA$52.95Near-term monthly trend
Monthly20-Month SMA$44.49Medium-term monthly trend
Monthly40-Month SMA$42.24Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$55.00 support 1.60x 1 months ago
$43.00 support 2.27x 4 months ago
$30.30 support 1.25x 11 months ago

Historical Earnings Reactions (48 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.47% 0.00% 45.83% 8.96% -9.97%
1 Day -1.68% -1.78% 31.25% 12.83% -17.46%
1 Week -3.83% -3.43% 22.92% 17.59% -30.16%
2 Weeks -1.37% -3.09% 37.50% 27.58% -26.19%
1 Month 0.32% -1.30% 44.68% 51.58% -53.89%

Next earnings: October 25, 2026 (59 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan0.8%41.7%12
Feb7.6%75.0%12
Mar-4.0%25.0%12
Apr1.8%50.0%12
May-3.6%33.3%12
Jun3.8%50.0%12
Jul2.1%41.7%12
Aug7.5%72.7%11
Sep-5.9%18.2%11
Oct5.5%45.5%11
Nov5.0%72.7%11
Dec9.0%66.7%12

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.33% 46.6% 556
Tuesday 0.12% 48.3% 611
Wednesday 0.01% 50.0% 608
Thursday 0.17% 48.5% 596
Friday 0.07% 49.0% 594

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 107.6%

Insider Transactions — Smart Summary

Total insider ownership: 0.1%

12-Month Insider Activity Summary

Total Filings13
Net Value-$19.5M
Net Shares Change-9,521
% of Float-0.0%
C-Suite Filings10
Clusters Detected1

Key Insiders

NameTitleNet ValueFilingsActivity
MORTIMER IAN PRESIDENT & CEO -$18.2M 4 N/A
GANNON STEVEN -$640,550 1 1 sell
KENNEY CHRISTOPHER JOHN Chief Medical Officer -$244,426.518 2 N/A
DiFabio Andrea Chief Legal Officer -$230,813.506 2 N/A
PATOU GARY -$70,251.08 1 N/A

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-03-11 – 2026-03-13 6 3 -$16.0M 6 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-08-13 GANNON STEVEN -$640,550 Transaction at $64.06, now -0.4%
2026-03-11 MORTIMER IAN PRESIDENT & CEO -$15.1M Transaction at $33.30, now +91.6%
2026-03-13 MORTIMER IAN PRESIDENT & CEO -$403,584.3 Transaction at $55.23, now +15.5%
2026-03-13 KENNEY CHRISTOPHER JOHN Chief Medical Officer -$77,867.25 Transaction at $55.23, now +15.5%
2026-03-13 DiFabio Andrea Chief Legal Officer -$74,111.95 Transaction at $55.23, now +15.5%
2026-03-11 KENNEY CHRISTOPHER JOHN Chief Medical Officer -$166,559.268 Transaction at $60.11, now +6.1%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Xenon Pharmaceuticals Inc (XENE) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for XENE on Trend Edge →