WVE — Wave Life Sciences Ltd

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

About Wave Life Sciences Ltd

Wave Life Sciences Ltd., a clinical-stage biotechnology company, designs, develops, and commercializes ribonucleic acid (RNA) medicines through PRISM, a discovery and drug development platform. The company's medicines platform, PRISM combines multiple modalities, chemistry innovation, and deep insights into human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$6.34
Market Cap$1.24B
Float90.1M
Shares Outstanding192.4M
Price/Sales (TTM)17.23
vs. Analyst Target+246.0% to analyst PT
Profit Margin-255.70%
Operating Margin (TTM)-81.83%
Revenue (TTM)$71.8M
Dividend RateNone
Analyst Target Price$21.94 (13 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $20.1M -$150M -$111M -$145M
2021 $41.0M -$122M $41.0M -$117M
2022 $3.6M -$162M $3.6M -$153M
2023 $113M -$57.5M $113M -$58.8M
2024 $108M -$97.0M $108M -$102M
2025 $42.7M -$204M $33.9M -$196M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $8.7M -$50.5M
Sep 2025 $7.6M -$53.9M
Dec 2025 $17.2M -$53.2M
Mar 2026 $38.2M -$26.1M

Ownership & Float

Insider Ownership15.9%
Institutional Ownership82.4%
Short Float18.6%
% of All Funds Holding2.58%
Number of Funds Holding212

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$6.95Near-term / short-term trend
Weekly40-Week SMA$9.89Medium-term trend
Weekly80-Week SMA$9.67Cyclical trend (business cycle)
Weekly200-Week SMA$7.06Secular trend (multi-year)
Monthly10-Month SMA$9.82Near-term monthly trend
Monthly20-Month SMA$9.90Medium-term monthly trend
Monthly40-Month SMA$7.51Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$13.60 resistance 1.59x 1 months ago
$17.00 resistance 1.34x 3 months ago
$5.80 support 2.26x 19 months ago
$4.90 support 2.18x 25 months ago

Historical Earnings Reactions (43 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.19% -0.15% 39.53% 5.37% -9.61%
1 Day -0.06% -0.74% 41.86% 17.45% -14.34%
1 Week 1.97% 0.72% 53.49% 42.06% -12.97%
2 Weeks 5.19% 2.97% 60.47% 55.11% -15.42%
1 Month 10.83% 7.08% 59.52% 134.89% -46.30%

Next earnings: July 17, 2026 (50 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan-8.1%27.3%11
Feb6.8%72.7%11
Mar-12.1%27.3%11
Apr-7.5%18.2%11
May0.1%50.0%10
Jun13.7%50.0%10
Jul1.0%50.0%10
Aug16.6%80.0%10
Sep2.4%40.0%10
Oct11.5%50.0%10
Nov10.0%60.0%10
Dec0.8%18.2%11

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.04% 48.0% 494
Tuesday 0.31% 49.3% 546
Wednesday 0.45% 51.8% 542
Thursday -0.12% 44.8% 533
Friday 0.08% 48.5% 532

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 82.4%

Insider Transactions — Smart Summary

Total insider ownership: 15.9%

12-Month Insider Activity Summary

Total Filings24
Net Value-$9.8M
Net Shares Change8,751,298
% of Float9.7%
C-Suite Filings9
Clusters Detected3

Key Insiders

NameTitleNet ValueFilingsActivity
RA CAPITAL MANAGEMENT, L.P. +$54.6M 2 2 buy
Moran Kyle Chief Financial Officer -$2.6M 2 1 sell
Tan Aik Na -$1.2M 1 N/A
HENRY CHRISTIAN O -$928,530.141 1 N/A
CORRIGAN MARK -$217,297.883 1 N/A
BOLNO PAUL President and CEO -$140,956 1 1 sell
Vargeese Chandra Chief Technology Officer, Head of Platform Discovery Sciences -$43,416.6 1 1 sell
Francis Chris SVP, Corporate Development, Head of Emerging Areas -$25,326.35 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-08-07 – 2025-08-19 4 3 -$140,203.95
2025-12-10 – 2025-12-10 8 8 -$10.0M 2 C-suite
2026-02-11 – 2026-02-11 4 4 -$257,957.55 4 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-03-30 RA CAPITAL MANAGEMENT, L.P. +$54.6M Transaction at $6.23, now +1.8%
2026-02-11 Vargeese Chandra Chief Technology Officer, Head of Platform Discovery Sciences -$43,416.6 Transaction at $13.45, now -52.9%
2026-02-11 Moran Kyle Chief Financial Officer -$48,258.6 Transaction at $13.45, now -52.9%
2026-02-11 Francis Chris SVP, Corporate Development, Head of Emerging Areas -$25,326.35 Transaction at $13.45, now -52.9%
2026-02-11 BOLNO PAUL President and CEO -$140,956 Transaction at $13.45, now -52.9%
2025-11-14 RA CAPITAL MANAGEMENT, L.P. +$6,687.5 Transaction at $6.69, now -5.2%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Wave Life Sciences Ltd (WVE) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for WVE on Trend Edge →