VRTX — Vertex Pharmaceuticals Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates VRTX Bullish with a Setup Score of 52, net conviction 44, actionability 62. How the Setup Score works →

Total Setup Score52
Directional BiasBullish
Net Conviction44
Actionability62 (in range)

Key signals behind this score

About Vertex Pharmaceuticals Inc

Vertex Pharmaceuticals Incorporated operates as a biotechnology company in the United States, Europe, and internationally. The company offers transformative medicines for people with serious diseases with a focus on specialty markets, such as cystic fibrosis (CF), sickle cell disease (SCD), transfusion dependent beta thalassemia (TDT), and acute pain. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$510.08
Market Cap$127.55B
Float252.7M
Shares Outstanding253.5M
P/E (Forward)24.10
P/E (TTM)29.31
Price/Sales (TTM)10.13
vs. Analyst Target+12.1% to analyst PT
Profit Margin35.00%
Operating Margin (TTM)38.06%
Revenue (TTM)$12.59B
Earnings Growth (YoY)8.00%
Dividend RateNone
Analyst Target Price$571.61 (32 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $6.21B $2.71B $5.47B $3.28B
2021 $7.57B $2.34B $6.67B $2.92B
2022 $8.93B $3.32B $7.85B $4.44B
2023 $9.87B $3.62B $8.61B $4.61B
2024 $11.02B -$536M $9.49B $486M
2025 $12.07B $3.95B $10.27B $4.86B

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 $3.08B $1.08B
Dec 2025 $3.23B $1.19B
Mar 2026 $2.99B $1.03B
Jun 2026 $3.33B $1.10B

Ownership & Float

Insider Ownership0.2%
Institutional Ownership98.0%
Short Float1.8%
% of All Funds Holding19.65%
Number of Funds Holding1,728

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$520.25Near-term / short-term trend
Weekly40-Week SMA$475.24Medium-term trend
Weekly80-Week SMA$455.85Cyclical trend (business cycle)
Weekly200-Week SMA$422.38Secular trend (multi-year)
Monthly10-Month SMA$483.94Near-term monthly trend
Monthly20-Month SMA$463.65Medium-term monthly trend
Monthly40-Month SMA$444.48Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$433.00 support 1.24x 3 months ago

Historical Earnings Reactions (122 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.53% 0.01% 50.00% 15.71% -29.64%
1 Day -0.52% -0.24% 47.54% 22.22% -36.76%
1 Week -0.49% -0.35% 47.54% 34.56% -30.04%
2 Weeks 0.73% -0.69% 49.18% 65.30% -29.01%
1 Month 1.59% 0.84% 52.89% 60.39% -31.92%

Next earnings: November 2, 2026 (21 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan3.4%65.7%35
Feb0.2%45.7%35
Mar-2.2%42.9%35
Apr1.6%60.0%35
May7.7%57.1%35
Jun3.2%57.1%35
Jul-0.6%45.7%35
Aug4.9%63.9%36
Sep2.8%47.2%36
Oct0.1%54.3%35
Nov-2.0%48.6%35
Dec7.2%65.7%35

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.02% 46.0% 1669
Tuesday 0.00% 47.6% 1820
Wednesday 0.12% 48.6% 1816
Thursday 0.11% 49.2% 1784
Friday 0.34% 50.5% 1773

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 98.0%

Insider Transactions — Smart Summary

Total insider ownership: 0.2%

12-Month Insider Activity Summary

Total Filings56
Net Value-$149M
Net Shares Change-156,042
% of Float-0.1%
C-Suite Filings50
Clusters Detected5

Key Insiders

NameTitleNet ValueFilingsActivity
Kewalramani Reshma CEO & President -$19.7M 1 N/A
Sachdev Amit EVP Chief Patient & Ext Af Off -$19.1M 1 N/A
WAGNER CHARLES F JR EVP, CO & FO -$6.4M 1 N/A
Bozic Carmen EVP and CMO -$5.0M 2 N/A
McKechnie Duncan EVP, Chief Commercial Officer -$799,779 1 N/A
Upadhyay Suketu +N/A 1 1 sell
Thornberry Nancy +N/A 1 1 sell
Schneider Jennifer +N/A 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-12-05 – 2025-12-05 4 4 -$31.7M 4 C-suite
2026-02-12 – 2026-02-26 21 8 -$48.6M 20 C-suite
2026-03-02 – 2026-03-13 6 5 -$23.9M 6 C-suite
2026-05-05 – 2026-05-19 9 8 -$4.4M 4 C-suite
2026-07-06 – 2026-07-07 3 3 -$2.0M 3 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-05-05 Upadhyay Suketu +N/A N/A
2026-05-05 Thornberry Nancy +N/A N/A
2026-05-05 Schneider Jennifer +N/A N/A
2026-05-05 MCKENZIE DIANA +N/A N/A
2026-06-17 Bozic Carmen EVP and CMO -$1.8M Transaction at $450.00, now +13.4%
2026-05-14 Bozic Carmen EVP and CMO -$3.1M Transaction at $450.00, now +13.4%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Vertex Pharmaceuticals Inc (VRTX) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for VRTX on Trend Edge →