VNDA — Vanda Pharmaceuticals Inc

Founder-Led

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

About Vanda Pharmaceuticals Inc

Vanda Pharmaceuticals Inc., a biopharmaceutical company, focuses on the development and commercialization of therapies to address high unmet medical needs worldwide. The company's commercial portfolio includes Fanapt for the acute treatment of manic or mixed episodes associated with bipolar I disorder and the treatment of schizophrenia; HETLIOZ to treat non-24-hour sleep-wake disorders and nighttime sleep disturbances; PONVORY to treat relapsing … Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$6.46
Market Cap$373M
Float53.8M
Shares Outstanding60.1M
P/E (Forward)103.09
Price/Sales (TTM)1.71
vs. Analyst Target+130.7% to analyst PT
Profit Margin-109.99%
Operating Margin (TTM)-97.11%
Revenue (TTM)$218M
Earnings Growth (YoY)-95.90%
Dividend RateNone
Analyst Target Price$14.90 (3 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $248M $23.3M $225M $34.5M
2021 $269M $33.2M $243M $45.0M
2022 $254M $6.3M $230M $9.1M
2023 $193M $2.5M $193M -$14.0M
2024 $199M -$18.9M $187M -$32.5M
2025 $216M -$220M $203M -$139M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $52.6M -$27.2M
Sep 2025 $56.3M -$22.6M
Dec 2025 $57.2M -$141M
Mar 2026 $51.7M -$48.6M

Ownership & Float

Insider Ownership6.1%
Institutional Ownership78.7%
Short Float11.5%
% of All Funds Holding1.86%
Number of Funds Holding153

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$6.75Near-term / short-term trend
Weekly40-Week SMA$6.30Medium-term trend
Weekly80-Week SMA$5.44Cyclical trend (business cycle)
Weekly200-Week SMA$5.87Secular trend (multi-year)
Monthly10-Month SMA$6.52Near-term monthly trend
Monthly20-Month SMA$5.57Medium-term monthly trend
Monthly40-Month SMA$5.36Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$8.60 resistance 1.58x 1 months ago
$5.40 support 3.42x 4 months ago
$4.50 support 1.40x 5 months ago

Historical Earnings Reactions (81 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.30% 0.00% 48.15% 24.50% -15.61%
1 Day 0.00% -0.37% 46.91% 26.83% -21.94%
1 Week 10.28% -1.01% 44.44% 676.24% -24.37%
2 Weeks 15.18% 0.60% 53.09% 1031.68% -20.06%
1 Month 19.71% 1.79% 51.25% 1210.89% -42.56%

Next earnings: July 25, 2026 (58 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan-3.2%45.0%20
Feb0.2%50.0%20
Mar-2.9%40.0%20
Apr-1.1%45.0%20
May71.8%45.0%20
Jun4.8%60.0%20
Jul-3.3%40.0%20
Aug-0.3%45.0%20
Sep-4.8%30.0%20
Oct-1.2%45.0%20
Nov5.4%65.0%20
Dec5.2%55.0%20

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.08% 46.0% 949
Tuesday 0.04% 45.1% 1039
Wednesday 0.26% 48.2% 1038
Thursday 0.63% 47.0% 1019
Friday -0.03% 46.4% 1015

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 78.7%

Insider Transactions — Smart Summary

Total insider ownership: 6.1%

Founder-led management: Mihael H. Polymeropoulos (Founder, President, Chief Executive Officer & Chairman of the Board)

12-Month Insider Activity Summary

Total Filings8
Net Value-$2.5M
Net Shares Change-341,342
% of Float-0.6%
C-Suite Filings6
Clusters Detected1

Key Insiders

NameTitleNet ValueFilingsActivity
Polymeropoulos Mihael Hristos President and CEO -$1.2M 2 1 buy, 1 sell
Moran Kevin Patrick SVP, CFO and Treasurer -$350,821.328 1 1 sell
Williams Timothy SVP and General Counsel -$350,755.201 1 1 sell
Birznieks Gunther SVP, Business Development -$350,730.403 1 1 sell
Wijkstrom Joakim SVP, Chief Marketing Officer -$254,589.72 1 1 sell
Honore Tage -$240,900 1 1 sell
Mitchell Stephen Ray -$32,130 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-02-24 – 2026-03-04 6 6 -$2.8M 5 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-03-04 Williams Timothy SVP and General Counsel -$350,755.201 Transaction at $8.27, now -21.8%
2026-03-04 Polymeropoulos Mihael Hristos President and CEO -$1.3M Transaction at $8.17, now -21.0%
2026-03-04 Wijkstrom Joakim SVP, Chief Marketing Officer -$254,589.72 Transaction at $8.27, now -21.8%
2026-03-04 Moran Kevin Patrick SVP, CFO and Treasurer -$350,821.328 Transaction at $8.27, now -21.8%
2026-03-04 Birznieks Gunther SVP, Business Development -$350,730.403 Transaction at $8.27, now -21.8%
2025-08-08 Polymeropoulos Mihael Hristos President and CEO +$41,500 Transaction at $4.15, now +55.7%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Vanda Pharmaceuticals Inc (VNDA) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for VNDA on Trend Edge →