TNGX — Tango Therapeutics Inc

Founder-Led

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates TNGX Bullish with a Setup Score of 0, net conviction 61, actionability 0. How the Setup Score works →

Total Setup Score0
Directional BiasBullish
Net Conviction61
Actionability0 (extended)

Key signals behind this score

About Tango Therapeutics Inc

Tango Therapeutics, Inc., a precision oncology company, focuses on the discovery and development of drugs in defined patient populations with unmet medical need. The company develops methylthioadenosine -cooperative protein arginine methyltransferase 5 (PRMT5) inhibitors, including TNG462, which is in Phase 1/2 clinical trial for treating pancreatic and lung cancer; and TNG456, a brain-penetrant PRMT5 inhibitor for the treatment of glioblastoma. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$31.06
Market Cap$4.97B
Float69.6M
Shares Outstanding162.8M
Price/Sales (TTM)87.19
vs. Analyst Target+41.1% to analyst PT
Profit Margin-188.15%
Operating Margin (TTM)-206.22%
Revenue (TTM)$57.0M
Dividend RateNone
Analyst Target Price$43.82 (8 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $7.7M -$52.0M $6.0M -$50.3M
2021 $37.0M -$58.2M $37.0M -$57.3M
2022 $24.9M -$108M $24.9M -$109M
2023 $36.5M -$102M $36.5M -$99.2M
2024 $42.1M -$130M $42.1M -$128M
2025 $62.4M -$102M $60.1M -$99.3M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $3.2M -$38.9M
Sep 2025 $53.8M $15.9M
Dec 2025 N/A -$38.7M
Mar 2026 N/A -$45.5M

Ownership & Float

Insider Ownership1.2%
Institutional Ownership114.3%
Short Float48.9%
% of All Funds Holding2.17%
Number of Funds Holding178

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$25.69Near-term / short-term trend
Weekly40-Week SMA$16.39Medium-term trend
Weekly80-Week SMA$10.21Cyclical trend (business cycle)
Weekly200-Week SMA$8.31Secular trend (multi-year)
Monthly10-Month SMA$17.75Near-term monthly trend
Monthly20-Month SMA$10.84Medium-term monthly trend
Monthly40-Month SMA$9.15Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$21.80 support 1.89x 0 months ago
$10.90 support 1.44x 3 months ago
$8.90 support 1.14x 5 months ago
$8.00 support 1.28x 7 months ago
$2.30 support 2.25x 12 months ago

Historical Earnings Reactions (23 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.19% 0.29% 56.52% 10.70% -7.76%
1 Day 0.05% -0.46% 47.83% 11.34% -12.65%
1 Week 10.20% 7.17% 69.57% 100.58% -16.00%
2 Weeks 9.91% 5.65% 56.52% 111.92% -17.97%
1 Month 18.01% 3.20% 54.55% 258.02% -27.36%

Next earnings: August 4, 2026 (22 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

Insufficient historical data for monthly seasonality analysis (requires 7+ years of data).

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.20% 48.7% 273
Tuesday 0.10% 45.9% 303
Wednesday 0.42% 48.2% 301
Thursday 0.06% 48.8% 293
Friday 0.40% 48.5% 293

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 114.3%

Insider Transactions — Smart Summary

Total insider ownership: 1.2%

Founder-led management: Barbara Weber (Founder & Executive Chair)

12-Month Insider Activity Summary

Total Filings17
Net Value-$4.7M
Net Shares Change-3,477,073
% of Float-5.0%
C-Suite Filings11
Clusters Detected1

Key Insiders

NameTitleNet ValueFilingsActivity
Third Rock Ventures IV, L.P. -$26.4M 6 6 sell
Crystal Adam President, R&D -$530,065.864 2 1 sell
Weber Barbara Director, Executive Chair -$374,294.172 1 1 sell
Beckman Daniella Chief Financial Officer -$126,530.783 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-02-04 – 2026-02-04 3 3 -$727,125.818 3 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-02-04 Crystal Adam President, R&D -$226,300.864 Transaction at $12.26, now +153.3%
2026-02-04 Beckman Daniella Chief Financial Officer -$126,530.783 Transaction at $12.26, now +153.3%
2026-02-04 Weber Barbara Director, Executive Chair -$374,294.172 Transaction at $12.26, now +153.3%
2025-08-21 Third Rock Ventures IV, L.P. -$7.7M Transaction at $7.01, now +343.0%
2025-09-09 Third Rock Ventures IV, L.P. -$5.1M Transaction at $7.00, now +343.4%
2025-10-27 Third Rock Ventures IV, L.P. -$4.8M Transaction at $10.15, now +205.9%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Tango Therapeutics Inc (TNGX) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for TNGX on Trend Edge →