Stock analysis, trade plans, and proprietary indicators by Trend Edge.
About Spero Therapeutics Inc
Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has comple… Read full Trend Edge analysis →
Sector: Healthcare
Industry: Biotechnology
Exchange: NASDAQ
IPO Date: November 2, 2017
Headquarters: 675 Massachusetts Avenue, Cambridge, MA, United States, 02139
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
Timeframe
SMA
Value
Trend Context
Weekly
10-Week SMA
$2.64
Near-term / short-term trend
Weekly
40-Week SMA
$2.37
Medium-term trend
Weekly
80-Week SMA
$1.88
Cyclical trend (business cycle)
Weekly
200-Week SMA
$1.64
Secular trend (multi-year)
Monthly
10-Month SMA
$2.33
Near-term monthly trend
Monthly
20-Month SMA
$1.87
Medium-term monthly trend
Monthly
40-Month SMA
$1.66
Secular monthly trend
Volume Shelves — Support & Resistance
Trend Edge identifies volume shelves: price zones where historically elevated trading volume
creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative
volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
Price Level
Type
Volume Ratio
Age
$2.60
support
1.25x
0 months ago
$0.70
support
8.51x
11 months ago
Historical Earnings Reactions (34 events)
Timeframe
Avg Return
Median
Win Rate
Best
Worst
Gap
-1.49%
0.03%
50.00%
6.06%
-20.61%
1 Day
-2.78%
-2.04%
20.59%
13.11%
-20.36%
1 Week
-3.00%
-2.10%
41.18%
21.18%
-32.72%
2 Weeks
1.33%
-4.43%
36.36%
208.70%
-37.43%
1 Month
1.33%
-5.59%
33.33%
313.04%
-79.89%
Next earnings: August 1, 2026 (65 days away)
Seasonality & Day-of-Week Patterns
Monthly Seasonality
Month
Avg Return
Win Rate
Samples
Jan
2.8%
44.4%
9
Feb
-4.1%
44.4%
9
Mar
0.2%
44.4%
9
Apr
-2.3%
33.3%
9
May
23.8%
37.5%
8
Jun
0.6%
50.0%
8
Jul
-6.2%
25.0%
8
Aug
2.7%
25.0%
8
Sep
14.1%
37.5%
8
Oct
0.1%
37.5%
8
Nov
1.8%
50.0%
8
Dec
-1.2%
33.3%
9
Day-of-Week Tendencies
Day
Avg Return
Win Rate
Samples
Monday
0.02%
45.5%
402
Tuesday
0.19%
45.5%
444
Wednesday
0.48%
43.7%
439
Thursday
0.27%
45.9%
431
Friday
-0.30%
44.3%
433
Top Institutional Holders
Institutional holder breakdown coming soon.
Total institutional ownership: 16.1%
Insider Transactions — Smart Summary
Total insider ownership: 22.5%
12-Month Insider Activity Summary
Total Filings
8
Net Value
-$762,871.044
Net Shares Change
-16,291
% of Float
-0.0%
C-Suite Filings
7
Clusters Detected
0
Key Insiders
Name
Title
Net Value
Filings
Activity
Rajavelu Esther
Chief Executive Officer, Chief Financial Officer and Chief Business Officer
-$614,337.7
4
1 sell
Keutzer Timothy
Chief Operating Officer
-$148,533.345
3
1 sell
Mahadevia Ankit
-$12,946.84
1
1 sell
Significant Filings
Date
Insider
Title
Net Value
Price After
2025-11-12
Rajavelu Esther
Chief Executive Officer, Chief Financial Officer and Chief Business Officer
-$95,439.9
Transaction at $2.37, now +23.6%
2025-09-02
Keutzer Timothy
Chief Operating Officer
-$3,339.15
Transaction at $1.97, now +48.7%
2025-09-02
Mahadevia Ankit
-$12,946.84
Transaction at $1.97, now +48.7%
2026-02-09
Rajavelu Esther
Chief Executive Officer, Chief Financial Officer and Chief Business Officer
-$270,841.28
Transaction at $2.39, now +22.4%
2026-02-04
Rajavelu Esther
Chief Executive Officer, Chief Financial Officer and Chief Business Officer
-$40,572.4
Transaction at $2.20, now +33.2%
2026-02-09
Rajavelu Esther
Chief Executive Officer, Chief Financial Officer and Chief Business Officer
Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Spero Therapeutics Inc
(SPRO) powered by Claude Opus — Anthropic's most capable AI model.
The analysis covers five layers:
technical analysis (near-term, medium-term, cyclical, and secular trend, momentum,
volume shelf support and resistance, breakout and breakdown signals),
qualitative analysis (business model, competitive moat, sector dynamics),
insider sentiment (buy and sell signals from executive and director transactions),
share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and
fundamental analysis (valuation, revenue growth, profit margin, earnings quality).
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Whether you are building a long position, initiating a short, or looking for a reversal setup,
AI Consult identifies the highest-probability signal from the current trend.