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Sionna Therapeutics, Inc., a clinical-stage biopharmaceutical company, researches and develops medicines for the treatment of cystic fibrosis (CF). It develops galicaftor (SION-2222), a transmembrane domain 1 (TMD1)-directed cystic fibrosis transmembrane conductance regulator (CFTR) that has completed Phase 2 trial; navocaftor (SION-3067), a potentiator that has completed Phase 2 trial; SION-109, an intracellular loop 4 directed CFTR corrector th… Read full Trend Edge analysis →
| Current Price | $42.88 |
|---|---|
| Market Cap | $1.89B |
| Float | 16.5M |
| Shares Outstanding | 45.2M |
| vs. Analyst Target | +20.3% to analyst PT |
| Dividend Rate | None |
| Analyst Target Price | $51.60 (3 analysts) |
| Year | Revenue | Net Income | Gross Profit | EBITDA |
|---|---|---|---|---|
| 2022 | N/A | -$40.2M | N/A | -$41.3M |
| 2023 | N/A | -$47.3M | N/A | -$49.8M |
| 2024 | N/A | -$61.7M | -$668,000 | -$69.9M |
| 2025 | N/A | -$75.3M | -$647,000 | -$88.3M |
| Quarter | Revenue | Net Income |
|---|---|---|
| Jun 2025 | N/A | -$18.1M |
| Sep 2025 | N/A | -$20.3M |
| Dec 2025 | N/A | -$20.4M |
| Mar 2026 | N/A | -$26.8M |
| Insider Ownership | 6.8% |
|---|---|
| Institutional Ownership | 100.6% |
| Short Float | 25.6% |
| % of All Funds Holding | 1.34% |
| Number of Funds Holding | 110 |
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
| Timeframe | SMA | Value | Trend Context |
|---|---|---|---|
| Weekly | 10-Week SMA | $40.38 | Near-term / short-term trend |
| Weekly | 40-Week SMA | $37.04 | Medium-term trend |
| Weekly | 80-Week SMA | $0.00 | Cyclical trend (business cycle) |
| Weekly | 200-Week SMA | $0.00 | Secular trend (multi-year) |
| Monthly | 10-Month SMA | $37.74 | Near-term monthly trend |
| Monthly | 20-Month SMA | $0.00 | Medium-term monthly trend |
| Monthly | 40-Month SMA | $0.00 | Secular monthly trend |
Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
| Price Level | Type | Volume Ratio | Age |
|---|---|---|---|
| $32.90 | support | 1.22x | 1 months ago |
| Timeframe | Avg Return | Median | Win Rate | Best | Worst |
|---|---|---|---|---|---|
| Gap | -1.04% | -0.54% | 0.00% | 0.00% | -3.64% |
| 1 Day | 1.12% | -0.04% | 50.00% | 5.32% | -1.94% |
| 1 Week | 1.69% | 4.76% | 66.67% | 12.26% | -16.71% |
| 2 Weeks | 2.62% | 5.66% | 60.00% | 25.91% | -28.17% |
| 1 Month | 14.64% | 18.56% | 80.00% | 26.98% | -5.69% |
Next earnings: July 31, 2026 (65 days away)
Insufficient historical data for monthly seasonality analysis (requires 7+ years of data).
Institutional holder breakdown coming soon.
Total institutional ownership: 100.6%
Total insider ownership: 6.8%
Founder-led management: Greg Hurlbut (Co-Founder and Senior Vice President, Discovery Research), Mark Munson (Co-Founder and Senior Vice President, Medicinal Chemistry)
| Total Filings | 35 |
|---|---|
| Net Value | -$7.9M |
| Net Shares Change | -3,579,969 |
| % of Float | -21.7% |
| C-Suite Filings | 11 |
| Clusters Detected | 4 |
| Name | Title | Net Value | Filings | Activity |
|---|---|---|---|---|
| Thompson Peter A. | -$36.3M | 2 | N/A | |
| ORBIMED ADVISORS LLC | -$36.3M | 2 | N/A | |
| RA CAPITAL MANAGEMENT, L.P. | -$21.5M | 3 | 3 sell | |
| TPG GP A, LLC | -$9.0M | 2 | 1 buy, 1 sell | |
| Ridloff Elena | CFO and Head of Corp. Dev. | -$1.1M | 1 | N/A |
| Period | Filings | Insiders | Net Value | Seniority |
|---|---|---|---|---|
| 2025-10-15 – 2025-10-28 | 6 | 3 | -$36.6M | 2 C-suite |
| 2025-11-19 – 2025-11-26 | 4 | 3 | -$16.3M | |
| 2025-12-09 – 2025-12-19 | 3 | 3 | -$519,558 | 1 C-suite |
| 2026-01-26 – 2026-02-04 | 3 | 3 | -$12.8M |
| Date | Insider | Title | Net Value | Price After |
|---|---|---|---|---|
| 2025-07-01 | TPG GP A, LLC | +$950,400 | Transaction at $15.84, now +170.7% | |
| 2026-01-26 | TPG GP A, LLC | -$10.0M | Transaction at $40.00, now +7.2% | |
| 2026-04-16 | Thompson Peter A. | -$22.9M | Transaction at $44.94, now -4.6% | |
| 2026-04-16 | ORBIMED ADVISORS LLC | -$22.9M | Transaction at $44.94, now -4.6% | |
| 2025-10-28 | RA CAPITAL MANAGEMENT, L.P. | -$14.8M | Transaction at $39.51, now +8.5% | |
| 2026-05-11 | Thompson Peter A. | -$13.4M | Transaction at $45.62, now -6.0% |
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