Stock analysis, trade plans, and proprietary indicators by Trend Edge.
Trend Edge rates SION Bullish with a Setup Score of 0, net conviction 30, actionability 0. How the Setup Score works →
| Total Setup Score | 0 |
|---|---|
| Directional Bias | Bullish |
| Net Conviction | 30 |
| Actionability | 0 (no mans land) |
Sionna Therapeutics, Inc., a clinical-stage biopharmaceutical company, researches and develops medicines for the treatment of cystic fibrosis (CF). It develops galicaftor (SION-2222), a transmembrane domain 1 (TMD1)-directed cystic fibrosis transmembrane conductance regulator (CFTR) that has completed Phase 2 trial; navocaftor (SION-3067), a potentiator that has completed Phase 2 trial; SION-109, an intracellular loop 4 directed CFTR corrector th… Read full Trend Edge analysis →
| Current Price | $5.59 |
|---|---|
| Market Cap | $250M |
| Float | 17.0M |
| Shares Outstanding | 45.2M |
| vs. Analyst Target | +171.3% to analyst PT |
| Dividend Rate | None |
| Analyst Target Price | $15.17 (3 analysts) |
| Year | Revenue | Net Income | Gross Profit | EBITDA |
|---|---|---|---|---|
| 2022 | N/A | -$40.2M | N/A | -$40.1M |
| 2023 | N/A | -$47.3M | N/A | -$46.7M |
| 2024 | N/A | -$61.7M | -$668,000 | -$61.0M |
| 2025 | N/A | -$75.3M | -$647,000 | -$74.6M |
| Quarter | Revenue | Net Income |
|---|---|---|
| Sep 2025 | N/A | -$20.3M |
| Dec 2025 | N/A | -$20.4M |
| Mar 2026 | N/A | -$26.8M |
| Jun 2026 | N/A | -$29.9M |
| Insider Ownership | 6.8% |
|---|---|
| Institutional Ownership | 107.6% |
| Short Float | 24.7% |
| % of All Funds Holding | 1.68% |
| Number of Funds Holding | 148 |
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
| Timeframe | SMA | Value | Trend Context |
|---|---|---|---|
| Weekly | 10-Week SMA | $34.21 | Near-term / short-term trend |
| Weekly | 40-Week SMA | $38.12 | Medium-term trend |
| Weekly | 80-Week SMA | $29.38 | Cyclical trend (business cycle) |
| Weekly | 200-Week SMA | $0.00 | Secular trend (multi-year) |
| Monthly | 10-Month SMA | $38.18 | Near-term monthly trend |
| Monthly | 20-Month SMA | $0.00 | Medium-term monthly trend |
| Monthly | 40-Month SMA | $0.00 | Secular monthly trend |
Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
| Price Level | Type | Volume Ratio | Age |
|---|---|---|---|
| $46.00 | resistance | 5.62x | 0 months ago |
| Timeframe | Avg Return | Median | Win Rate | Best | Worst |
|---|---|---|---|---|---|
| Gap | -0.53% | -0.39% | 14.29% | 2.52% | -3.64% |
| 1 Day | 1.37% | 0.50% | 57.14% | 5.32% | -1.94% |
| 1 Week | -10.98% | 2.28% | 57.14% | 12.26% | -86.98% |
| 2 Weeks | -10.25% | 4.54% | 57.14% | 25.91% | -89.34% |
| 1 Month | 10.19% | 16.27% | 66.67% | 26.98% | -12.07% |
Next earnings: October 25, 2026 (61 days away)
Insufficient historical data for monthly seasonality analysis (requires 7+ years of data).
Institutional holder breakdown coming soon.
Total institutional ownership: 107.6%
Total insider ownership: 6.8%
Founder-led management: Greg Hurlbut (Co-Founder and Senior Vice President, Discovery Research), Mark Munson (Co-Founder and Senior Vice President, Medicinal Chemistry)
| Total Filings | 39 |
|---|---|
| Net Value | -$6.7M |
| Net Shares Change | -3,991,695 |
| % of Float | -23.4% |
| C-Suite Filings | 10 |
| Clusters Detected | 6 |
| Name | Title | Net Value | Filings | Activity |
|---|---|---|---|---|
| Thompson Peter A. | -$28.2M | 2 | N/A | |
| ORBIMED ADVISORS LLC | -$28.2M | 2 | N/A | |
| RA CAPITAL MANAGEMENT, L.P. | -$21.5M | 3 | 3 sell | |
| TPG GP A, LLC | -$10.0M | 1 | 1 sell | |
| Ridloff Elena | CFO & Head of Corp. Dev. | -$842,298.24 | 2 | N/A |
| Period | Filings | Insiders | Net Value | Seniority |
|---|---|---|---|---|
| 2025-08-28 – 2025-09-05 | 4 | 3 | -$1.5M | 4 C-suite |
| 2025-10-15 – 2025-10-28 | 6 | 3 | -$36.6M | 2 C-suite |
| 2025-11-19 – 2025-11-26 | 4 | 3 | -$16.3M | |
| 2025-12-09 – 2025-12-19 | 3 | 3 | -$519,558 | 1 C-suite |
| 2026-01-26 – 2026-02-04 | 3 | 3 | -$12.8M | |
| 2026-07-02 – 2026-07-09 | 5 | 3 | -$18.6M | 1 C-suite |
| Date | Insider | Title | Net Value | Price After |
|---|---|---|---|---|
| 2025-10-28 | RA CAPITAL MANAGEMENT, L.P. | -$14.8M | Transaction at $39.51, now -85.9% | |
| 2026-01-26 | TPG GP A, LLC | -$10.0M | Transaction at $40.00, now -86.0% | |
| 2025-11-19 | RA CAPITAL MANAGEMENT, L.P. | -$5.5M | Transaction at $40.34, now -86.1% | |
| 2025-11-24 | RA CAPITAL MANAGEMENT, L.P. | -$1.2M | Transaction at $39.61, now -85.9% | |
| 2026-04-16 | Thompson Peter A. | -$22.9M | Transaction at $44.94, now -87.6% | |
| 2026-04-16 | ORBIMED ADVISORS LLC | -$22.9M | Transaction at $44.94, now -87.6% |
Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Sionna Therapeutics, Inc. Common Stock (SION) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).
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Get the full AI Consult analysis for SION on Trend Edge →