RYTM — Rhythm Pharmaceuticals Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates RYTM Bullish with a Setup Score of 54, net conviction 45, actionability 64. How the Setup Score works →

Total Setup Score54
Directional BiasBullish
Net Conviction45
Actionability64 (in range)

Key signals behind this score

About Rhythm Pharmaceuticals Inc

Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases in the United States and internationally. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, Bardet-Biedl and Alström syndrome, Prader-Willi syn… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$113.35
Market Cap$7.63B
Float56.0M
Shares Outstanding68.9M
Price/Sales (TTM)31.79
vs. Analyst Target+24.9% to analyst PT
Profit Margin-85.59%
Operating Margin (TTM)-68.14%
Revenue (TTM)$240M
Dividend RateNone
Analyst Target Price$141.53 (12 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $35,000 -$131M -$690,000 -$136M
2021 $3.2M -$68.0M $2.6M -$169M
2022 $23.6M -$181M $21.5M -$174M
2023 $77.4M -$185M $68.1M -$168M
2024 $130M -$261M $117M -$238M
2025 $190M -$197M $170M -$174M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 $51.3M -$52.9M
Dec 2025 $57.3M -$47.5M
Mar 2026 $60.1M -$55.6M
Jun 2026 $71.3M -$49.3M

Ownership & Float

Insider Ownership0.7%
Institutional Ownership114.7%
Short Float16.8%
% of All Funds Holding3.44%
Number of Funds Holding303

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$109.48Near-term / short-term trend
Weekly40-Week SMA$98.87Medium-term trend
Weekly80-Week SMA$88.86Cyclical trend (business cycle)
Weekly200-Week SMA$57.26Secular trend (multi-year)
Monthly10-Month SMA$99.17Near-term monthly trend
Monthly20-Month SMA$87.59Medium-term monthly trend
Monthly40-Month SMA$62.88Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$88.00 support 1.29x 1 months ago
$64.00 support 1.58x 12 months ago
$54.00 support 1.80x 15 months ago
$48.00 support 1.37x 20 months ago

Historical Earnings Reactions (36 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.45% -0.17% 41.67% 6.67% -9.50%
1 Day 0.06% -1.09% 47.22% 23.71% -16.54%
1 Week 1.22% 1.54% 55.56% 51.73% -44.05%
2 Weeks 0.16% 1.17% 55.56% 70.50% -48.61%
1 Month 3.71% 2.06% 54.29% 77.84% -44.86%

Next earnings: October 23, 2026 (57 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan-5.2%33.3%9
Feb-4.9%33.3%9
Mar-5.7%11.1%9
Apr1.4%55.6%9
May-4.6%33.3%9
Jun7.0%55.6%9
Jul23.9%44.4%9
Aug23.9%75.0%8
Sep-4.1%37.5%8
Oct-1.5%37.5%8
Nov13.7%77.8%9
Dec4.1%55.6%9

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.29% 52.9% 418
Tuesday 0.29% 52.8% 460
Wednesday 0.41% 51.3% 456
Thursday -0.19% 46.2% 448
Friday 0.02% 48.5% 447

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 114.7%

Insider Transactions — Smart Summary

Total insider ownership: 0.7%

12-Month Insider Activity Summary

Total Filings17
Net Value-$24.7M
Net Shares Change-66,394
% of Float-0.1%
C-Suite Filings16
Clusters Detected1

Key Insiders

NameTitleNet ValueFilingsActivity
Lee Jennifer Kayden EVP, Head of North America -$7.9M 1 N/A
Mazabraud Yann EVP, Head of International -$6.3M 1 N/A
TETRAULT LYNN A. -$2.7M 1 N/A
Smith Hunter C Chief Financial Officer -$2.2M 3 N/A
Garfield Alastair Chief Scientific Officer -$912,702.897 1 N/A
German Christopher Paul Corporate Controller & CAO -$716,652.949 2 2 sell
Shulman Joseph Chief Technical Officer -$594,447.05 1 N/A

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-08-14 – 2026-08-17 4 4 -$15.7M 4 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-08-14 Mazabraud Yann EVP, Head of International -$6.3M Transaction at $61.48, now +84.4%
2026-08-17 Shulman Joseph Chief Technical Officer -$594,447.05 Transaction at $63.27, now +79.1%
2026-08-17 Garfield Alastair Chief Scientific Officer -$912,702.897 Transaction at $117.57, now -3.6%
2026-05-19 German Christopher Paul Corporate Controller & CAO -$240,818.109 Transaction at $67.19, now +68.7%
2026-03-06 German Christopher Paul Corporate Controller & CAO -$475,834.84 Transaction at $53.77, now +110.8%
2026-02-19 Smith Hunter C Chief Financial Officer -$805,813.377 Transaction at $101.31, now +11.9%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Rhythm Pharmaceuticals Inc (RYTM) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for RYTM on Trend Edge →