RVMD — Revolution Medicines Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates RVMD Bullish with a Setup Score of 53, net conviction 46, actionability 62. How the Setup Score works →

Total Setup Score53
Directional BiasBullish
Net Conviction46
Actionability62 (in range)

Key signals behind this score

About Revolution Medicines Inc

Revolution Medicines, Inc., a clinical-stage precision oncology company, develops novel targeted therapies for RAS-addicted cancers. The company's research and development pipeline consist of RAS(ON) inhibitors that binds RAS variants to be used as monotherapy in combination with other RAS(ON) inhibitors and/or in combination with RAS companion inhibitors or other therapeutic agents, and RAS companion inhibitors to suppress cooperating targets an… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$189.76
Market Cap$40.32B
Float184.6M
Shares Outstanding214.3M
Price/Sales (TTM)9,035.10
vs. Analyst Target+36.4% to analyst PT
Revenue (TTM)$742,000
Dividend RateNone
Analyst Target Price$258.84 (23 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $43.0M -$108M $43.0M -$102M
2021 $29.4M -$187M $29.4M -$180M
2022 $35.4M -$249M $35.4M -$239M
2023 $11.6M -$436M $11.6M -$430M
2024 N/A -$600M -$592M -$589M
2025 N/A -$1.13B -$16.6M -$1.09B

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 N/A -$305M
Dec 2025 N/A -$365M
Mar 2026 N/A -$454M
Jun 2026 N/A -$644M

Ownership & Float

Insider Ownership1.9%
Institutional Ownership101.3%
Short Float5.3%
% of All Funds Holding7.79%
Number of Funds Holding685

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$203.23Near-term / short-term trend
Weekly40-Week SMA$151.69Medium-term trend
Weekly80-Week SMA$100.18Cyclical trend (business cycle)
Weekly200-Week SMA$60.29Secular trend (multi-year)
Monthly10-Month SMA$157.32Near-term monthly trend
Monthly20-Month SMA$103.17Medium-term monthly trend
Monthly40-Month SMA$69.98Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$162.00 support 1.14x 3 months ago
$97.00 support 1.55x 5 months ago
$81.00 support 2.12x 8 months ago
$59.00 support 1.09x 10 months ago
$47.00 support 1.22x 11 months ago

Historical Earnings Reactions (27 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -1.08% -0.99% 33.33% 9.54% -11.71%
1 Day 0.71% -0.23% 48.15% 15.85% -10.97%
1 Week 1.79% 1.77% 51.85% 21.18% -9.23%
2 Weeks 0.94% 1.76% 51.85% 19.98% -18.68%
1 Month 4.66% 5.85% 65.38% 32.06% -23.19%

Next earnings: November 4, 2026 (25 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

Insufficient historical data for monthly seasonality analysis (requires 7+ years of data).

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.09% 50.6% 312
Tuesday 0.37% 50.7% 345
Wednesday 0.23% 52.8% 343
Thursday 0.04% 49.3% 335
Friday 0.27% 52.6% 333

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 101.3%

Insider Transactions — Smart Summary

Total insider ownership: 1.9%

12-Month Insider Activity Summary

Total Filings57
Net Value-$122M
Net Shares Change-177,072
% of Float-0.1%
C-Suite Filings53
Clusters Detected9

Key Insiders

NameTitleNet ValueFilingsActivity
Kim Lorence H. -$11.4M 1 N/A
Mancini Anthony Chief Global Commercialization Officer -$4.3M 4 1 sell
GOLDSMITH MARK A President and Chief Executive Officer -$2.8M 1 N/A
ANDERSON ELIZABETH M -$2.0M 1 N/A
Horn Margaret A Chief Operating Officer -$989,612.663 1 N/A
Patel Sushil -$938,036.76 1 N/A
Cislini Jeff SVP & General Counsel -$670,631.405 1 N/A

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-10-15 – 2025-10-20 3 3 -$2.3M 3 C-suite
2025-11-12 – 2025-11-26 7 3 -$10.2M 7 C-suite
2025-12-18 – 2025-12-18 5 5 -$2.4M 5 C-suite
2026-01-09 – 2026-01-23 3 3 -$5.3M 3 C-suite
2026-03-19 – 2026-03-26 8 8 -$5.5M 8 C-suite
2026-06-15 – 2026-06-26 8 6 -$20.0M 8 C-suite
2026-08-25 – 2026-09-02 3 3 -$39.8M 2 C-suite
2026-09-10 – 2026-09-24 12 9 -$30.4M 10 C-suite
2026-09-28 – 2026-10-01 3 3 -$1.7M 3 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-06-18 Mancini Anthony Chief Global Commercialization Officer -$720,490.108 Transaction at $156.12, now +21.5%
2026-09-14 Mancini Anthony Chief Global Commercialization Officer -$2.8M Transaction at $118.89, now +59.6%
2026-09-02 Kim Lorence H. -$11.4M Transaction at $203.24, now -6.6%
2026-09-18 Cislini Jeff SVP & General Counsel -$670,631.405 Transaction at $199.24, now -4.8%
2026-09-24 ANDERSON ELIZABETH M -$2.0M Transaction at $97.08, now +95.5%
2026-09-18 GOLDSMITH MARK A President and Chief Executive Officer -$2.8M Transaction at $199.24, now -4.8%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Revolution Medicines Inc (RVMD) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for RVMD on Trend Edge →