QURE — Uniqure NV

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates QURE Bullish with a Setup Score of 21, net conviction 34, actionability 13. How the Setup Score works →

Total Setup Score21
Directional BiasBullish
Net Conviction34
Actionability13 (in range)

Key signals behind this score

About Uniqure NV

uniQure N.V. develops treatments for patients suffering from rare and other devastating diseases in the United States. The company offers HEMGENIX that allows people living with hemophilia B to produce factor IX, which can lower the risk of bleeding. Its lead product candidate is AMT-130, a gene therapy candidate, which is in Phase I/II clinical study for the treatment of Huntington's disease. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$42.63
Market Cap$3.06B
Float56.5M
Shares Outstanding68.8M
P/E (Forward)27.93
Price/Sales (TTM)169.03
vs. Analyst Target+52.1% to analyst PT
Operating Margin (TTM)-1321.11%
Revenue (TTM)$18.1M
Earnings Growth (YoY)-18.20%
Dividend RateNone
Analyst Target Price$64.86 (13 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $37.5M -$125M -$84.9M -$127M
2021 $524M $330M $499M $319M
2022 $106M -$127M $103M -$108M
2023 $15.8M -$308M $2.2M -$253M
2024 $27.1M -$240M $8.8M -$161M
2025 $16.1M -$199M $14.4M -$117M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $5.3M -$37.7M
Sep 2025 $3.7M -$80.5M
Dec 2025 $5.6M -$37.1M
Mar 2026 $3.6M -$53.5M

Ownership & Float

Insider Ownership1.3%
Institutional Ownership90.2%
Short Float20.9%
% of All Funds Holding2.41%
Number of Funds Holding198

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$33.97Near-term / short-term trend
Weekly40-Week SMA$28.58Medium-term trend
Weekly80-Week SMA$22.45Cyclical trend (business cycle)
Weekly200-Week SMA$15.95Secular trend (multi-year)
Monthly10-Month SMA$31.10Near-term monthly trend
Monthly20-Month SMA$25.00Medium-term monthly trend
Monthly40-Month SMA$16.39Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$9.20 support 1.74x 3 months ago
$10.80 support 1.03x 14 months ago
$6.60 support 2.62x 18 months ago
$4.50 support 4.60x 23 months ago

Historical Earnings Reactions (48 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.50% 0.00% 41.67% 8.63% -12.67%
1 Day 1.29% 1.20% 58.33% 18.15% -14.05%
1 Week 2.49% 1.37% 54.17% 73.90% -21.08%
2 Weeks 1.40% 1.18% 52.08% 48.76% -27.95%
1 Month 2.76% 3.02% 56.25% 63.43% -34.15%

Next earnings: August 4, 2026 (22 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan-0.9%25.0%12
Feb3.3%50.0%12
Mar-4.6%30.8%13
Apr3.4%46.2%13
May7.3%69.2%13
Jun3.9%46.2%13
Jul3.3%25.0%12
Aug0.6%50.0%12
Sep12.3%25.0%12
Oct6.0%50.0%12
Nov6.2%75.0%12
Dec12.5%25.0%12

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.21% 45.3% 585
Tuesday 0.29% 47.6% 643
Wednesday 0.51% 46.1% 640
Thursday 0.24% 50.5% 628
Friday 0.24% 46.6% 624

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 90.2%

Insider Transactions — Smart Summary

Total insider ownership: 1.3%

12-Month Insider Activity Summary

Total Filings36
Net Value-$22.3M
Net Shares Change-113,479
% of Float-0.2%
C-Suite Filings20
Clusters Detected3

Key Insiders

NameTitleNet ValueFilingsActivity
O'Keefe Kylie Chief Customer & Strat Officer -$431,228.16 1 1 sell
Potts Jeannette Chief Legal Officer -$175,820.51 2 2 sell
Abi-Saab Walid Chief Medical Officer -$67,197.24 1 1 sell
Springhorn Jeremy P. -$53,930.58 1 1 sell
POST LEONARD E -$53,930.58 1 1 sell
Meek David D. -$53,930.58 1 1 sell
Kaye Jack -$53,930.58 1 1 sell
Jacques Rachelle Suzanne -$53,930.58 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-02-27 – 2026-03-06 10 4 -$1.3M 10 C-suite
2026-06-05 – 2026-06-17 11 9 -$1.4M 2 C-suite
2026-06-22 – 2026-07-02 7 4 -$10.9M 4 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-06-12 O'Keefe Kylie Chief Customer & Strat Officer -$431,228.16 Transaction at $27.06, now +57.5%
2026-06-17 Potts Jeannette Chief Legal Officer -$144,907.79 Transaction at $27.67, now +54.1%
2026-06-12 Springhorn Jeremy P. -$53,930.58 Transaction at $27.06, now +57.5%
2026-06-12 POST LEONARD E -$53,930.58 Transaction at $27.06, now +57.5%
2026-06-12 Meek David D. -$53,930.58 Transaction at $27.06, now +57.5%
2026-06-12 Kaye Jack -$53,930.58 Transaction at $27.06, now +57.5%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Uniqure NV (QURE) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for QURE on Trend Edge →