PTGX — Protagonist Therapeutics Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

About Protagonist Therapeutics Inc

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare b… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$102.21
Market Cap$6.50B
Float52.5M
Shares Outstanding64.3M
P/E (Forward)21.60
Price/Sales (TTM)87.70
vs. Analyst Target+14.8% to analyst PT
Profit Margin-154.88%
Operating Margin (TTM)-6.47%
Revenue (TTM)$74.1M
Earnings Growth (YoY)351.30%
Dividend RateNone
Analyst Target Price$117.33 (10 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $28.6M -$66.2M $28.6M -$63.6M
2021 $27.4M -$126M $27.4M -$123M
2022 $26.6M -$123M $26.6M -$128M
2023 $60.0M -$79.0M $60.0M -$90.3M
2024 $434M $275M $434M $254M
2025 $46.0M -$130M $44.8M -$128M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $5.5M -$34.8M
Sep 2025 $4.7M -$39.3M
Dec 2025 $7.4M -$44.4M
Mar 2026 $56.4M $3.8M

Ownership & Float

Insider Ownership0.7%
Institutional Ownership125.3%
Short Float14.4%
% of All Funds Holding3.59%
Number of Funds Holding295

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$100.89Near-term / short-term trend
Weekly40-Week SMA$85.94Medium-term trend
Weekly80-Week SMA$66.07Cyclical trend (business cycle)
Weekly200-Week SMA$40.48Secular trend (multi-year)
Monthly10-Month SMA$86.19Near-term monthly trend
Monthly20-Month SMA$65.82Medium-term monthly trend
Monthly40-Month SMA$46.02Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$93.00 support 1.08x 1 months ago
$66.00 support 1.59x 6 months ago
$60.00 support 1.30x 7 months ago
$48.00 support 1.17x 10 months ago
$41.00 support 1.94x 13 months ago

Historical Earnings Reactions (40 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 1.20% 0.44% 57.50% 27.30% -7.92%
1 Day 2.68% 0.34% 50.00% 83.70% -22.38%
1 Week 3.76% 1.96% 57.50% 109.57% -29.23%
2 Weeks 7.79% 3.64% 62.50% 104.92% -21.31%
1 Month 8.97% 8.34% 58.97% 109.57% -57.49%

Next earnings: July 24, 2026 (56 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan3.1%60.0%10
Feb0.5%50.0%10
Mar7.8%50.0%10
Apr-11.9%20.0%10
May20.6%66.7%9
Jun9.4%77.8%9
Jul0.3%55.6%9
Aug16.2%77.8%9
Sep0.5%50.0%10
Oct4.0%40.0%10
Nov7.7%60.0%10
Dec1.4%50.0%10

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.31% 47.3% 459
Tuesday 0.32% 53.5% 507
Wednesday 0.20% 51.1% 503
Thursday -0.10% 48.6% 494
Friday 0.52% 51.4% 496

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 125.3%

Insider Transactions — Smart Summary

Total insider ownership: 0.7%

12-Month Insider Activity Summary

Total Filings23
Net Value-$38.3M
Net Shares Change-213,345
% of Float-0.4%
C-Suite Filings16
Clusters Detected2

Key Insiders

NameTitleNet ValueFilingsActivity
PATEL DINESH V PH D President and CEO -$13.8M 3 3 sell
Ali Asif Chief Financial Officer -$5.7M 3 3 sell
Giraudo Bryan -$5.7M 1 2 sell
MOLINA ARTURO MD Chief Medical Officer -$3.3M 2 2 sell
SELICK HAROLD E -$2.2M 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-01-21 – 2026-01-27 6 3 -$13.1M 6 C-suite
2026-03-25 – 2026-03-27 4 4 -$10.9M 3 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-05-11 Giraudo Bryan -$5.7M Transaction at $68.93, now +48.3%
2026-05-12 PATEL DINESH V PH D President and CEO -$5.9M Transaction at $60.85, now +68.0%
2026-03-25 PATEL DINESH V PH D President and CEO -$5.1M Transaction at $54.79, now +86.5%
2026-04-21 Ali Asif Chief Financial Officer -$184,572.5 Transaction at $105.47, now -3.1%
2026-03-27 MOLINA ARTURO MD Chief Medical Officer -$1.5M Transaction at $56.42, now +81.2%
2026-03-27 Ali Asif Chief Financial Officer -$2.1M Transaction at $60.97, now +67.6%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Protagonist Therapeutics Inc (PTGX) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for PTGX on Trend Edge →