PTCT — PTC Therapeutics Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates PTCT Bullish with a Setup Score of 62, net conviction 39, actionability 100. How the Setup Score works →

Total Setup Score62
Directional BiasBullish
Net Conviction39
Actionability100 (in range)

Key signals behind this score

About PTC Therapeutics Inc

PTC Therapeutics, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of medicines to children and adults living with rare disorders in the United States and internationally. The company provides Translarna and Emflaza for the treatment of Duchenne muscular dystrophy; Upstaza to treat aromatic l-amino acid decarboxylas (AADC) deficiency, a central nervous system disorder; Tegsedi and Waylivra for the tr… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$64.70
Market Cap$5.22B
Float73.7M
Shares Outstanding83.5M
P/E (Forward)22.73
Price/Sales (TTM)5.18
vs. Analyst Target+56.2% to analyst PT
Profit Margin-3.81%
Operating Margin (TTM)41.32%
Revenue (TTM)$1.01B
Dividend RateNone
Analyst Target Price$101.07 (14 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $381M -$438M $362M -$303M
2021 $539M -$524M $506M -$368M
2022 $699M -$559M $654M -$368M
2023 $938M -$627M $872M -$330M
2024 $807M -$363M $749M -$120M
2025 $1.73B $683M $1.66B $888M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 $211M $15.9M
Dec 2025 $165M -$135M
Mar 2026 $273M -$2.8M
Jun 2026 $361M $83.5M

Ownership & Float

Insider Ownership7.3%
Institutional Ownership122.8%
Short Float13.3%
% of All Funds Holding4.33%
Number of Funds Holding381

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$67.65Near-term / short-term trend
Weekly40-Week SMA$71.25Medium-term trend
Weekly80-Week SMA$64.70Cyclical trend (business cycle)
Weekly200-Week SMA$48.56Secular trend (multi-year)
Monthly10-Month SMA$69.94Near-term monthly trend
Monthly20-Month SMA$64.53Medium-term monthly trend
Monthly40-Month SMA$49.52Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$81.00 resistance 1.20x 2 months ago
$62.00 support 1.03x 11 months ago
$50.00 support 1.29x 12 months ago

Historical Earnings Reactions (53 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.55% -0.33% 45.28% 14.86% -19.16%
1 Day -0.81% 0.92% 54.72% 27.59% -32.96%
1 Week 1.43% 0.31% 50.94% 33.33% -22.81%
2 Weeks 2.62% 0.63% 52.83% 102.24% -29.07%
1 Month 8.40% 8.68% 54.72% 96.00% -30.83%

Next earnings: November 3, 2026 (22 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan9.3%61.5%13
Feb0.2%53.8%13
Mar-6.7%38.5%13
Apr2.0%46.2%13
May3.1%53.8%13
Jun5.6%61.5%13
Jul1.4%64.3%14
Aug6.0%71.4%14
Sep3.1%50.0%14
Oct-7.5%38.5%13
Nov13.4%69.2%13
Dec3.1%61.5%13

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.17% 49.4% 628
Tuesday -0.11% 50.1% 689
Wednesday 0.27% 50.9% 684
Thursday -0.00% 51.6% 671
Friday 0.42% 50.1% 670

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 122.8%

Insider Transactions — Smart Summary

Total insider ownership: 7.3%

12-Month Insider Activity Summary

Total Filings67
Net Value-$28.4M
Net Shares Change-221,059
% of Float-0.3%
C-Suite Filings51
Clusters Detected9

Key Insiders

NameTitleNet ValueFilingsActivity
Almstead Neil Gregory CHIEF TECHNICAL OPS OFFICER -$3.6M 1 N/A
Klein Matthew B. CHIEF EXECUTIVE OFFICER -$705,722.44 1 N/A
Reeve Emma -$653,210.64 2 N/A
Golden Lee Scott EVP & CHIEF MEDICAL OFFICER -$633,800 1 N/A
Pauwels Eric CHIEF BUSINESS OFFICER -$565,945.899 1 N/A
STEELE GLENN JR MD PHD -$545,880 1 N/A
Okey Stephanie -$401,385.54 1 N/A
Gravier Pierre CHIEF FINANCIAL OFFICER -$280,742.9 1 N/A

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-11-19 – 2025-12-03 5 5 -$8.0M 3 C-suite
2025-12-23 – 2026-01-06 5 5 -$1.5M 3 C-suite
2026-01-08 – 2026-01-12 13 7 -$3.4M 13 C-suite
2026-02-19 – 2026-02-23 8 7 -$2.0M 8 C-suite
2026-03-09 – 2026-03-13 5 4 -$2.0M 3 C-suite
2026-04-03 – 2026-04-08 3 3 -$3.7M 3 C-suite
2026-06-12 – 2026-06-26 5 4 -$5.2M 5 C-suite
2026-06-30 – 2026-07-13 5 3 -$3.7M 4 C-suite
2026-10-02 – 2026-10-09 3 3 -$856,713.373 1 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-04-03 Almstead Neil Gregory CHIEF TECHNICAL OPS OFFICER -$3.6M Transaction at $69.04, now -6.3%
2026-03-09 Golden Lee Scott EVP & CHIEF MEDICAL OFFICER -$633,800 Transaction at $63.38, now +2.1%
2026-01-06 Boulding Mark Elliott EXEC. VP AND CLO -$81,866.275 Transaction at $57.48, now +12.6%
2026-08-06 Klein Matthew B. CHIEF EXECUTIVE OFFICER -$705,722.44 Transaction at $68.57, now -5.6%
2026-07-16 Gravier Pierre CHIEF FINANCIAL OFFICER -$280,742.9 Transaction at $80.35, now -19.5%
2026-03-09 Okey Stephanie -$401,385.54 Transaction at $63.38, now +2.1%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for PTC Therapeutics Inc (PTCT) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for PTCT on Trend Edge →