PRTA — Prothena Corporation plc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates PRTA Bearish with a Setup Score of 41, net conviction 27, actionability 62. How the Setup Score works →

Total Setup Score41
Directional BiasBearish
Net Conviction27
Actionability62 (in range)

Key signals behind this score

About Prothena Corporation plc

Prothena Corporation plc, a late-stage clinical biotechnology company, focuses on discovery and development of novel therapies to treat diseases caused by protein dysregulation. Its product pipeline includes Prasinezumab, an investigational humanized monoclonal antibody which is in Phase 3 clinical trial for the treatment of parkinson's disease and other synucleinopathies. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$9.24
Market Cap$505M
Float36.7M
Shares Outstanding52.4M
P/E (Forward)10.63
Price/Sales (TTM)8.71
vs. Analyst Target+131.6% to analyst PT
Profit Margin-260.92%
Operating Margin (TTM)50.49%
Revenue (TTM)$57.9M
Dividend RateNone
Analyst Target Price$21.40 (6 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $853,000 -$111M $853,000 -$106M
2021 $201M $67.0M $201M $78.8M
2022 $53.9M -$117M $53.9M -$131M
2023 $91.4M -$147M $91.4M -$160M
2024 $135M -$122M $135M -$128M
2025 $9.7M -$244M $6.0M -$197M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $4.4M -$126M
Sep 2025 $2.4M -$36.5M
Dec 2025 $21,000 -$21.6M
Mar 2026 $51.1M $32.7M

Ownership & Float

Insider Ownership20.2%
Institutional Ownership90.9%
Short Float21.4%
% of All Funds Holding2.03%
Number of Funds Holding167

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$9.54Near-term / short-term trend
Weekly40-Week SMA$9.74Medium-term trend
Weekly80-Week SMA$9.76Cyclical trend (business cycle)
Weekly200-Week SMA$27.99Secular trend (multi-year)
Monthly10-Month SMA$9.85Near-term monthly trend
Monthly20-Month SMA$9.97Medium-term monthly trend
Monthly40-Month SMA$22.50Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$6.80 support 1.22x 10 months ago
$4.60 support 2.08x 12 months ago
$12.20 resistance 1.34x 14 months ago
$16.40 resistance 1.43x 18 months ago

Historical Earnings Reactions (54 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.24% -0.20% 46.30% 10.01% -18.71%
1 Day 1.25% 0.20% 50.00% 45.54% -8.27%
1 Week 1.37% 0.86% 51.85% 39.81% -17.05%
2 Weeks 3.42% 3.12% 61.11% 45.45% -24.79%
1 Month 5.27% 1.22% 52.83% 107.44% -40.93%

Next earnings: August 3, 2026 (21 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan-7.4%35.7%14
Feb9.0%57.1%14
Mar4.9%64.3%14
Apr-10.3%42.9%14
May1.0%50.0%14
Jun12.6%64.3%14
Jul11.9%76.9%13
Aug2.9%46.2%13
Sep5.4%46.2%13
Oct-1.0%53.8%13
Nov6.7%53.8%13
Dec-4.9%23.1%13

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.19% 48.8% 639
Tuesday -0.11% 49.7% 700
Wednesday 0.37% 48.8% 697
Thursday 0.07% 49.0% 684
Friday 0.45% 52.4% 681

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 90.9%

Insider Transactions — Smart Summary

Total insider ownership: 20.2%

12-Month Insider Activity Summary

Total Filings5
Net Value+N/A
Net Shares Change345,000
% of Float0.9%
C-Suite Filings0
Clusters Detected0

Key Insiders

NameTitleNet ValueFilingsActivity
SCULLY WILLIAM P +$3.1M 5 5 buy

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-06-12 SCULLY WILLIAM P +$1.0M Transaction at $8.17, now +13.1%
2026-06-18 SCULLY WILLIAM P +$157,990 Transaction at $7.90, now +17.0%
2026-05-26 SCULLY WILLIAM P +$981,300 Transaction at $9.81, now -5.8%
2026-06-03 SCULLY WILLIAM P +$471,300 Transaction at $9.43, now -2.0%
2026-06-05 SCULLY WILLIAM P +$465,295 Transaction at $9.31, now -0.7%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Prothena Corporation plc (PRTA) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for PRTA on Trend Edge →