ProQR Therapeutics N.V., a clinical-stage biotechnology company, focuses on the discovery and development of novel therapeutic medicines. The company develops an RNA editing platform through its Axiomer RNA editing technology for genetic disorders with unmet needs. Its lead product candidate, AX-0810, targets na-taurocholate cotransporting polypeptide (NTCP) for the treatment of cholestatic diseases. Read full Trend Edge analysis →
Sector: Healthcare
Industry: Biotechnology
Exchange: NASDAQ
IPO Date: September 18, 2014
Headquarters: Zernikedreef 9, Leiden, Netherlands, 2333 CK
Founder-Led: Yes — Daniel A. de Boer (Founder, Chief Executive Officer and Member of Management Board), Gerard Platenburg (Co-Founder, Chief Scientific Officer and Member of Management Board)
Key Metrics
Current Price
$2.38
Market Cap
$320M
Float
71.3M
Shares Outstanding
141.1M
Price/Sales (TTM)
17.39
vs. Analyst Target
+245.5% to analyst PT
Profit Margin
-228.18%
Operating Margin (TTM)
-100.72%
Revenue (TTM)
$18.4M
Dividend Rate
None
Analyst Target Price
$8.22 (8 analysts)
Financial History
Annual Revenue & Earnings History
Year
Revenue
Net Income
Gross Profit
EBITDA
2020
$1.0M
-$46.6M
$1.0M
-$48.4M
2021
$1.3M
-$60.7M
$1.3M
-$54.9M
2022
$3.6M
-$64.4M
$3.6M
-$56.5M
2023
$6.5M
-$28.1M
$6.5M
-$24.1M
2024
$18.9M
-$27.8M
$18.9M
-$24.1M
2025
$15.3M
-$40.5M
$12.7M
-$37.0M
Recent Quarterly Revenue & Net Income
Quarter
Revenue
Net Income
Sep 2025
$2.9M
-$11.0M
Dec 2025
$4.6M
-$8.8M
Mar 2026
$2.1M
-$13.6M
Jun 2026
$8.9M
-$8.9M
Ownership & Float
Insider Ownership
17.2%
Institutional Ownership
54.5%
Short Float
3.1%
% of All Funds Holding
0.80%
Number of Funds Holding
70
Current Moving Averages
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
Timeframe
SMA
Value
Trend Context
Weekly
10-Week SMA
$1.87
Near-term / short-term trend
Weekly
40-Week SMA
$1.77
Medium-term trend
Weekly
80-Week SMA
$1.90
Cyclical trend (business cycle)
Weekly
200-Week SMA
$2.04
Secular trend (multi-year)
Monthly
10-Month SMA
$1.83
Near-term monthly trend
Monthly
20-Month SMA
$1.93
Medium-term monthly trend
Monthly
40-Month SMA
$1.97
Secular monthly trend
Volume Shelves — Support & Resistance
Trend Edge identifies volume shelves: price zones where historically elevated trading volume
creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative
volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
Price Level
Type
Volume Ratio
Age
$1.80
support
1.23x
0 months ago
$3.80
resistance
1.04x
19 months ago
Historical Earnings Reactions (48 events)
Timeframe
Avg Return
Median
Win Rate
Best
Worst
Gap
0.42%
0.24%
56.25%
8.15%
-3.62%
1 Day
-0.52%
0.14%
50.00%
13.66%
-21.03%
1 Week
2.40%
1.84%
60.42%
26.49%
-12.43%
2 Weeks
3.59%
1.40%
55.32%
49.39%
-23.59%
1 Month
10.90%
0.90%
51.06%
189.93%
-31.61%
Next earnings: November 1, 2026 (66 days away)
Seasonality & Day-of-Week Patterns
Monthly Seasonality
Month
Avg Return
Win Rate
Samples
Jan
-14.5%
16.7%
12
Feb
-8.6%
41.7%
12
Mar
-0.1%
58.3%
12
Apr
-2.1%
33.3%
12
May
2.3%
50.0%
12
Jun
4.5%
58.3%
12
Jul
-3.2%
41.7%
12
Aug
8.5%
81.8%
11
Sep
7.1%
27.3%
11
Oct
4.0%
33.3%
12
Nov
4.1%
58.3%
12
Dec
20.1%
58.3%
12
Day-of-Week Tendencies
Day
Avg Return
Win Rate
Samples
Monday
-0.24%
42.1%
563
Tuesday
-0.15%
44.5%
618
Wednesday
0.35%
44.4%
615
Thursday
0.34%
44.7%
602
Friday
0.19%
47.8%
601
Top Institutional Holders
Institutional holder breakdown coming soon.
Total institutional ownership: 54.5%
Insider Transactions — Smart Summary
Total insider ownership: 17.2%
Founder-led management: Daniel A. de Boer (Founder, Chief Executive Officer and Member of Management Board), Gerard Platenburg (Co-Founder, Chief Scientific Officer and Member of Management Board)
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