PRME — Prime Medicine, Inc. Common Stock

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

About Prime Medicine, Inc. Common Stock

Prime Medicine, Inc., a biotechnology company, engages in delivering genetic medicines to address the spectrum of diseases by deploying gene editing technology in the United States. Its lead therapeutic product candidate is PM359 for Chronic Granulomatous Disease, which is in Phase 1/2 clinical trial; PM577 for Wilson Disease, that is in preclinical studies; and PM647 to treat genetic disorder caused by mutations in the SERPINA1 gene, resulting i… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$2.97
Market Cap$533M
Float108.7M
Shares Outstanding180.6M
Price/Sales (TTM)132.08
vs. Analyst Target+132.9% to analyst PT
Operating Margin (TTM)-5917.52%
Revenue (TTM)$4.0M
Dividend RateNone
Analyst Target Price$6.92 (12 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $5.2M -$3.4M $2.2M -$889,000
2021 N/A -$165M -$4.9M -$83.9M
2022 $5.2M -$122M -$12.0M -$114M
2023 N/A -$198M -$4.7M -$187M
2024 $3.0M -$196M $3.0M -$196M
2025 $4.6M -$201M -$2.7M -$196M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $1.1M -$52.6M
Sep 2025 $1.2M -$50.6M
Dec 2025 $838,000 -$46.1M
Mar 2026 $856,000 -$49.1M

Ownership & Float

Insider Ownership23.8%
Institutional Ownership66.4%
Short Float27.9%
% of All Funds Holding2.13%
Number of Funds Holding175

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$3.31Near-term / short-term trend
Weekly40-Week SMA$3.93Medium-term trend
Weekly80-Week SMA$3.26Cyclical trend (business cycle)
Weekly200-Week SMA$0.00Secular trend (multi-year)
Monthly10-Month SMA$3.94Near-term monthly trend
Monthly20-Month SMA$3.30Medium-term monthly trend
Monthly40-Month SMA$6.24Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$4.90 resistance 1.16x 5 months ago
$2.50 support 2.93x 9 months ago
$1.20 support 1.81x 10 months ago
$6.60 resistance 1.44x 22 months ago
$7.00 resistance 1.64x 24 months ago

Historical Earnings Reactions (15 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.30% -0.48% 46.67% 7.22% -7.65%
1 Day -0.71% -1.52% 40.00% 14.44% -11.31%
1 Week -1.94% -5.94% 33.33% 34.22% -30.79%
2 Weeks -5.30% -4.65% 33.33% 27.31% -30.56%
1 Month -2.71% -6.81% 42.86% 40.82% -30.56%

Next earnings: July 26, 2026 (60 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

Insufficient historical data for monthly seasonality analysis (requires 7+ years of data).

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.50% 51.8% 168
Tuesday -0.19% 45.7% 186
Wednesday -0.25% 43.5% 184
Thursday -0.47% 45.5% 178
Friday 0.32% 42.6% 183

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 66.4%

Insider Transactions — Smart Summary

Total insider ownership: 23.8%

12-Month Insider Activity Summary

Total Filings7
Net Value+N/A
Net Shares Change9,174,900
% of Float8.4%
C-Suite Filings0
Clusters Detected1

Key Insiders

NameTitleNet ValueFilingsActivity
NELSEN ROBERT +$10.0M 1 1 buy
ARCH Venture Partners XII, LLC +$10.0M 1 1 buy
ARCH Venture Partners X, LLC +$10.0M 1 1 buy
Liu David R. +$163,016.7 4 N/A

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-08-01 – 2025-08-01 3 3 +$30.0M

Significant Filings

DateInsiderTitleNet ValuePrice After
2025-08-01 NELSEN ROBERT +$10.0M Transaction at $3.30, now -10.0%
2025-08-01 ARCH Venture Partners XII, LLC +$10.0M Transaction at $3.30, now -10.0%
2025-08-01 ARCH Venture Partners X, LLC +$10.0M Transaction at $3.30, now -10.0%
2025-07-01 Liu David R. +$52,829.7 Transaction at $2.52, now +18.1%
2025-06-23 Liu David R. +$45,402 Transaction at $2.16, now +37.4%
2025-06-16 Liu David R. +$31,195.5 Transaction at $1.49, now +99.9%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Prime Medicine, Inc. Common Stock (PRME) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for PRME on Trend Edge →