PRAX — Praxis Precision Medicines Inc

Founder-Led

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates PRAX Bullish with a Setup Score of 43, net conviction 44, actionability 42. How the Setup Score works →

Total Setup Score43
Directional BiasBullish
Net Conviction44
Actionability42 (in range)

Key signals behind this score

About Praxis Precision Medicines Inc

Praxis Precision Medicines, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance in the United States. The company's platforms include Cerebrum, a small molecule platform for CNS small molecule therapies to develop orally available precision therapies; and Solidus to discover and develop antisense oligonucleoti… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$368.02
Market Cap$10.18B
Float24.1M
Shares Outstanding27.9M
Price/Sales (TTM)953.14
vs. Analyst Target+73.5% to analyst PT
Revenue (TTM)$7.5M
Dividend RateNone
Analyst Target Price$638.68 (12 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 N/A -$61.8M -$746,000 -$61.9M
2021 N/A -$167M -$1.6M -$167M
2022 $1.5M -$213M -$1.2M -$215M
2023 $2.4M -$123M -$84.3M -$123M
2024 $8.6M -$183M -$144M -$182M
2025 N/A -$303M -$140,000 -$303M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 N/A -$73.9M
Dec 2025 N/A -$88.9M
Mar 2026 N/A -$92.6M
Jun 2026 N/A -$83.7M

Ownership & Float

Insider Ownership0.3%
Institutional Ownership123.1%
Short Float15.2%
% of All Funds Holding3.50%
Number of Funds Holding308

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$339.04Near-term / short-term trend
Weekly40-Week SMA$311.81Medium-term trend
Weekly80-Week SMA$188.28Cyclical trend (business cycle)
Weekly200-Week SMA$99.82Secular trend (multi-year)
Monthly10-Month SMA$314.36Near-term monthly trend
Monthly20-Month SMA$188.32Medium-term monthly trend
Monthly40-Month SMA$115.14Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$194.00 support 1.40x 7 months ago
$53.00 support 2.65x 9 months ago
$42.00 support 1.13x 12 months ago

Historical Earnings Reactions (24 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.95% 0.36% 54.17% 13.00% -7.39%
1 Day 1.47% 0.50% 50.00% 24.63% -16.32%
1 Week 4.39% 0.08% 50.00% 48.17% -24.11%
2 Weeks 1.11% 0.61% 50.00% 51.10% -28.70%
1 Month -5.38% -8.30% 39.13% 62.98% -75.91%

Next earnings: October 25, 2026 (60 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

Insufficient historical data for monthly seasonality analysis (requires 7+ years of data).

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.40% 44.0% 275
Tuesday 0.19% 50.0% 304
Wednesday 0.71% 56.6% 302
Thursday 0.74% 48.6% 294
Friday 0.06% 49.8% 293

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 123.1%

Insider Transactions — Smart Summary

Total insider ownership: 0.3%

Founder-led management: Steve Petrou (Co-Founder and President of Research & Development)

12-Month Insider Activity Summary

Total Filings4
Net Value-$4.8M
Net Shares Change313,910
% of Float1.3%
C-Suite Filings2
Clusters Detected0

Key Insiders

NameTitleNet ValueFilingsActivity
Adage Capital Management, L.P. +$33.2M 1 N/A
Nemiroff Alex General Counsel and Secretary -$3.0M 1 1 sell
DeSimone Jill -$2.8M 1 N/A
Mastrocola Lauren Principal Accounting Officer -$1.8M 1 1 sell

Significant Filings

DateInsiderTitleNet ValuePrice After
2025-11-21 Nemiroff Alex General Counsel and Secretary -$3.0M Transaction at $133.42, now +175.8%
2025-11-21 Mastrocola Lauren Principal Accounting Officer -$1.8M Transaction at $126.60, now +190.7%
2025-10-17 Adage Capital Management, L.P. +$33.2M Transaction at $105.76, now +248.0%
2026-06-26 DeSimone Jill -$2.8M Transaction at $191.26, now +92.4%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Praxis Precision Medicines Inc (PRAX) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for PRAX on Trend Edge →