PALI — Palisade Bio Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates PALI Bullish with a Setup Score of 27, net conviction 30, actionability 24. How the Setup Score works →

Total Setup Score27
Directional BiasBullish
Net Conviction30
Actionability24 (in range)

Key signals behind this score

About Palisade Bio Inc

Palisade Bio, Inc., a clinical-stage biopharmaceutical company, engages in developing oral phosphodiesterase-4 inhibitor prodrugs designed for targeted delivery to the terminal ileum and colon in the United States. Its lead clinical product candidate includes PALI-2108, which is in phase 1b clinical trial to treat patients with inflammatory bowel disease, including ulcerative colitis and Fibrostenotic Crohn's disease. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$2.13
Market Cap$359M
Float138.9M
Shares Outstanding174.3M
P/E (TTM)3.32
Price/Sales (TTM)717.99
vs. Analyst Target+379.9% to analyst PT
Operating Margin (TTM)-2339.60%
Revenue (TTM)$500,000
Dividend RateNone
Analyst Target Price$10.22 (3 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $13,520 -$10.3M -$146,000 -$9.9M
2021 N/A -$26.6M -$168,000 -$24.2M
2022 $250,000 -$14.3M -$167,000 -$14.2M
2023 $250,000 -$12.3M $250,000 -$12.3M
2024 N/A -$14.4M -$3,000 -$14.4M
2025 N/A -$16.8M -$3,000 -$16.8M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 N/A -$2.9M
Dec 2025 N/A -$8.9M
Mar 2026 N/A -$9.6M
Jun 2026 $500,000 -$10.6M

Ownership & Float

Insider Ownership1.6%
Institutional Ownership101.5%
Short Float24.3%
% of All Funds Holding1.42%
Number of Funds Holding125

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$2.02Near-term / short-term trend
Weekly40-Week SMA$1.93Medium-term trend
Weekly80-Week SMA$1.46Cyclical trend (business cycle)
Weekly200-Week SMA$9.83Secular trend (multi-year)
Monthly10-Month SMA$1.97Near-term monthly trend
Monthly20-Month SMA$1.47Medium-term monthly trend
Monthly40-Month SMA$5.21Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$2.30 resistance 1.34x 6 months ago
$1.10 support 6.58x 9 months ago
$2.40 resistance 4.83x 19 months ago

Historical Earnings Reactions (74 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.20% 0.00% 36.49% 9.32% -8.70%
1 Day -0.32% 0.00% 47.30% 17.59% -15.00%
1 Week -0.14% -1.22% 41.89% 54.07% -44.75%
2 Weeks -0.25% -1.43% 41.89% 39.30% -34.67%
1 Month 2.63% 0.00% 47.22% 109.28% -42.75%

Next earnings: October 29, 2026 (63 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan1.0%57.9%19
Feb-3.1%47.4%19
Mar-0.4%42.1%19
Apr-3.2%45.0%20
May-8.0%30.0%20
Jun-5.1%25.0%20
Jul-8.4%40.0%20
Aug-9.2%36.8%19
Sep7.4%52.6%19
Oct-3.2%21.1%19
Nov0.0%42.1%19
Dec1.8%47.4%19

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.03% 41.5% 918
Tuesday -0.10% 38.2% 1003
Wednesday 0.02% 42.7% 1001
Thursday 0.15% 40.0% 982
Friday -0.40% 38.4% 976

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 101.5%

Insider Transactions — Smart Summary

Total insider ownership: 1.6%

12-Month Insider Activity Summary

Total Filings9
Net Value-$420,077.127
Net Shares Change418,237
% of Float0.3%
C-Suite Filings4
Clusters Detected1

Key Insiders

NameTitleNet ValueFilingsActivity
Finley John David CEO, CFO -$310,060.797 2 2 sell
Baltera Robert Jr. +$250,184.5 3 3 buy
Jones Mitchell Lawrence Chief Medical Officer -$110,016.33 2 2 sell
Williams Donald Allen +$17,756 2 2 buy

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-07-06 – 2026-07-10 5 3 -$159,593.877 2 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-07-10 Baltera Robert Jr. +$88,699.5 Transaction at $1.97, now +8.1%
2026-07-08 Baltera Robert Jr. +$102,085 Transaction at $2.04, now +4.3%
2026-07-06 Baltera Robert Jr. +$59,400 Transaction at $1.98, now +7.6%
2026-07-08 Jones Mitchell Lawrence Chief Medical Officer -$106,535.58 Transaction at $2.05, now +3.7%
2026-07-08 Finley John David CEO, CFO -$303,242.797 Transaction at $1.03, now +106.1%
2026-01-21 Williams Donald Allen +$8,356 Transaction at $1.67, now +27.5%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Palisade Bio Inc (PALI) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for PALI on Trend Edge →