ORKA — Oruka Therapeutics, Inc.

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates ORKA Bullish with a Setup Score of 0, net conviction 42, actionability 0. How the Setup Score works →

Total Setup Score0
Directional BiasBullish
Net Conviction42
Actionability0 (extended)

Key signals behind this score

About Oruka Therapeutics, Inc.

Oruka Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing novel monoclonal antibody therapeutics for psoriasis (PsO), and other inflammatory and immunology (I&I) indications. Its lead products include ORKA-001 that targets p19 subunit of interleukin-23, which is in phase 2a trial for the treatment of PsO; and ORKA-002 that targets interleukin-17A and interleukin-17F, which is in phase 2 trial for the treatment of… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$82.11
Market Cap$5.12B
Float56.9M
Shares Outstanding66.2M
vs. Analyst Target+88.8% to analyst PT
Dividend RateNone
Analyst Target Price$155.00 (13 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 N/A -$9.7M -$93,000 -$9.6M
2021 N/A -$19.3M -$91,000 -$19.2M
2022 N/A -$9.9M -$114,000 -$9.8M
2023 N/A -$5.3M -$111,000 -$5.2M
2024 N/A -$83.7M -$27,000 -$82.2M
2025 N/A -$105M -$83,000 -$105M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 N/A -$30.3M
Dec 2025 N/A -$29.6M
Mar 2026 N/A -$31.8M
Jun 2026 N/A -$41.2M

Ownership & Float

Insider Ownership1.3%
Institutional Ownership116.6%
Short Float13.7%
% of All Funds Holding2.92%
Number of Funds Holding257

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$93.99Near-term / short-term trend
Weekly40-Week SMA$66.59Medium-term trend
Weekly80-Week SMA$42.29Cyclical trend (business cycle)
Weekly200-Week SMA$32.24Secular trend (multi-year)
Monthly10-Month SMA$69.43Near-term monthly trend
Monthly20-Month SMA$43.67Medium-term monthly trend
Monthly40-Month SMA$34.61Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$55.00 support 1.81x 3 months ago
$50.00 support 3.45x 5 months ago
$32.90 support 1.78x 6 months ago
$19.20 support 1.69x 11 months ago
$14.80 support 1.65x 12 months ago

Historical Earnings Reactions (99 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.75% 0.00% 47.47% 18.75% -16.42%
1 Day -0.43% -0.49% 36.36% 42.22% -19.40%
1 Week -2.19% -2.53% 39.39% 51.11% -38.41%
2 Weeks -3.74% -4.36% 33.33% 35.56% -53.58%
1 Month -2.28% -2.79% 43.30% 105.66% -61.52%

Next earnings: November 11, 2026 (31 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan6.8%34.5%29
Feb3.6%37.9%29
Mar-6.1%37.9%29
Apr8.1%51.7%29
May5.2%44.8%29
Jun-0.7%41.4%29
Jul-1.2%44.8%29
Aug-8.8%24.1%29
Sep1.2%40.0%30
Oct-3.2%41.4%29
Nov-1.6%58.6%29
Dec1.4%48.3%29

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.16% 42.1% 1378
Tuesday -0.28% 41.0% 1506
Wednesday 0.11% 39.8% 1506
Thursday 0.05% 41.2% 1475
Friday 0.27% 43.1% 1468

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 116.6%

Insider Transactions — Smart Summary

Total insider ownership: 1.3%

12-Month Insider Activity Summary

Total Filings39
Net Value-$24.0M
Net Shares Change-104,723
% of Float-0.2%
C-Suite Filings36
Clusters Detected6

Key Insiders

NameTitleNet ValueFilingsActivity
Fairmount Funds Management LLC -$300M 1 1 sell
Klein Lawrence Otto Chief Executive Officer -$426,582.63 3 3 sell
Quinlan Paul T General Counsel -$180,798.36 3 3 sell
Sandler Laura Lee Chief Operating Officer -$153,307.26 3 3 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-03-17 – 2026-03-17 5 5 -$404,093.79 5 C-suite
2026-06-12 – 2026-06-22 7 6 -$3.8M 6 C-suite
2026-07-01 – 2026-07-15 4 4 -$302M 3 C-suite
2026-08-14 – 2026-08-17 3 3 -$6.7M 3 C-suite
2026-09-01 – 2026-09-15 7 5 -$8.6M 7 C-suite
2026-09-21 – 2026-10-02 3 3 -$2.8M 3 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-09-15 Quinlan Paul T General Counsel -$99,442.69 Transaction at $95.71, now -14.2%
2026-09-15 Sandler Laura Lee Chief Operating Officer -$86,713.26 Transaction at $95.71, now -14.2%
2026-09-15 Klein Lawrence Otto Chief Executive Officer -$234,680.92 Transaction at $95.71, now -14.2%
2026-06-15 Sandler Laura Lee Chief Operating Officer -$41,814 Transaction at $69.69, now +17.8%
2026-06-15 Quinlan Paul T General Counsel -$51,082.77 Transaction at $69.69, now +17.8%
2026-06-15 Klein Lawrence Otto Chief Executive Officer -$120,494.01 Transaction at $69.69, now +17.8%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Oruka Therapeutics, Inc. (ORKA) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for ORKA on Trend Edge →