OBIO — Orchestra BioMed Holdings Inc.

Founder-Led

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

About Orchestra BioMed Holdings Inc.

Orchestra BioMed Holdings, Inc. operates as a biomedical company in the United States. The company's flagship product candidates include Atrioventricular Interval Modulation, a bioelectronic therapy candidate designed to immediately, substantially, and persistently lower blood pressure; and Virtue Sirolimus AngioInfusion Balloon for the treatment of atherosclerotic artery disease. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$3.97
Market Cap$238M
Float33.6M
Shares Outstanding59.9M
Price/Sales (TTM)7.50
vs. Analyst Target+209.5% to analyst PT
Profit Margin-166.96%
Operating Margin (TTM)-20069.09%
Revenue (TTM)$32.7M
Dividend RateNone
Analyst Target Price$12.29 (7 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $5.7M -$21.4M $5.6M -$18.6M
2021 -$782,000 -$23.0M -$981,000 -$21.6M
2022 $3.5M -$33.6M $3.2M -$32.4M
2023 $2.8M -$49.1M $2.6M -$51.2M
2024 $2.6M -$61.0M $2.4M -$64.0M
2025 $33.5M -$52.7M $33.3M -$51.2M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $836,000 -$19.4M
Sep 2025 $861,000 -$20.8M
Dec 2025 $30.9M $6.2M
Mar 2026 $110,000 -$20.7M

Ownership & Float

Insider Ownership26.2%
Institutional Ownership41.7%
Short Float2.9%
% of All Funds Holding0.72%
Number of Funds Holding59

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$4.11Near-term / short-term trend
Weekly40-Week SMA$3.91Medium-term trend
Weekly80-Week SMA$3.90Cyclical trend (business cycle)
Weekly200-Week SMA$6.69Secular trend (multi-year)
Monthly10-Month SMA$3.87Near-term monthly trend
Monthly20-Month SMA$3.96Medium-term monthly trend
Monthly40-Month SMA$6.12Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$2.50 support 1.29x 6 months ago

Historical Earnings Reactions (23 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.44% 0.00% 39.13% 3.71% -9.81%
1 Day 0.25% 0.00% 39.13% 13.08% -24.30%
1 Week -0.86% 0.00% 47.83% 19.29% -34.81%
2 Weeks 4.79% 0.51% 59.09% 52.17% -34.11%
1 Month 2.73% 0.10% 50.00% 76.82% -35.98%

Next earnings: May 11, 2026

Seasonality & Day-of-Week Patterns

Monthly Seasonality

Insufficient historical data for monthly seasonality analysis (requires 7+ years of data).

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.52% 45.0% 271
Tuesday -0.06% 41.9% 301
Wednesday -0.01% 44.0% 300
Thursday -0.27% 42.1% 292
Friday 0.17% 45.7% 293

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 41.7%

Insider Transactions — Smart Summary

Total insider ownership: 26.2%

Founder-led management: David P. Hochman (Founder, Chairman of the Board of Directors & CEO), Darren R. Sherman (Founder, President, COO & Director)

12-Month Insider Activity Summary

Total Filings15
Net Value+$165,000
Net Shares Change2,034,713
% of Float6.1%
C-Suite Filings7
Clusters Detected2

Key Insiders

NameTitleNet ValueFilingsActivity
Hochman David P Chief Executive Officer and Chairperson +$137,100 4 4 buy
Fain Eric S +$82,600 1 1 buy
Aryeh Jason +$37,480.65 2 2 buy
Sherman Darren President and Chief Operating Officer +$7,860 1 1 buy
Taylor Andrew Lawrence Chief Financial Officer +$5,100 1 1 buy
RTW INVESTMENTS, LP -$7.157 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-08-25 – 2025-08-25 4 4 +$42,933.6 3 C-suite
2026-05-18 – 2026-05-20 4 3 +$138,930.65 1 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-05-19 Hochman David P Chief Executive Officer and Chairperson +$18,850 Transaction at $3.77, now +5.3%
2026-05-18 Fain Eric S +$82,600 Transaction at $4.13, now -3.9%
2026-05-19 Aryeh Jason +$34,986.9 Transaction at $3.90, now +1.8%
2026-05-20 Aryeh Jason +$2,493.75 Transaction at $3.75, now +5.9%
2026-03-16 Hochman David P Chief Executive Officer and Chairperson +$42,900 Transaction at $4.29, now -7.5%
2026-04-29 RTW INVESTMENTS, LP -$7.157 Transaction at $2.07, now +92.2%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Orchestra BioMed Holdings Inc. (OBIO) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for OBIO on Trend Edge →