MIST — Milestone Pharmaceuticals Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

About Milestone Pharmaceuticals Inc

Milestone Pharmaceuticals Inc., a biopharmaceutical company, focuses on the development and commercialization of cardiovascular medicines in the United States and Canada. It offers CARDAMYST (etripamil) nasal spray, a prescription medication for the conversion of acute symptomatic episodes of paroxysmal supraventricular tachycardia (PSVT) to sinus rhythm in adults. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$1.40
Market Cap$187M
Float14.1M
Shares Outstanding124.5M
Price/Sales (TTM)120.79
vs. Analyst Target+352.4% to analyst PT
Operating Margin (TTM)-1116.24%
Revenue (TTM)$1.5M
Dividend RateNone
Analyst Target Price$6.33 (4 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $15.0M -$50.0M -$376,000 -$50.6M
2021 $15.0M -$42.9M $15.0M -$43.0M
2022 $5.0M -$57.1M $5.0M -$59.6M
2023 $1.0M -$59.7M $1.0M -$57.0M
2024 N/A -$41.5M -$646,000 -$37.8M
2025 $1.5M -$63.1M $1.4M -$62.1M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 N/A -$13.0M
Sep 2025 N/A -$11.9M
Dec 2025 $1.5M -$17.4M
Mar 2026 $238,000 -$26.1M

Ownership & Float

Insider Ownership2.5%
Institutional Ownership25.0%
Short Float55.5%
% of All Funds Holding0.96%
Number of Funds Holding79

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$1.65Near-term / short-term trend
Weekly40-Week SMA$1.89Medium-term trend
Weekly80-Week SMA$1.78Cyclical trend (business cycle)
Weekly200-Week SMA$2.62Secular trend (multi-year)
Monthly10-Month SMA$1.85Near-term monthly trend
Monthly20-Month SMA$1.75Medium-term monthly trend
Monthly40-Month SMA$2.08Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$2.70 resistance 3.65x 4 months ago
$0.80 support 2.06x 12 months ago

Historical Earnings Reactions (29 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 1.07% 0.55% 55.17% 7.40% -3.07%
1 Day 1.42% 0.00% 48.28% 13.93% -7.40%
1 Week 1.53% -0.16% 48.28% 19.94% -25.74%
2 Weeks 3.40% 2.29% 53.57% 39.38% -56.65%
1 Month 2.01% 3.38% 57.14% 47.86% -89.67%

Next earnings: August 1, 2026 (64 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan2.9%42.9%7
Feb-11.6%14.3%7
Mar-18.6%42.9%7
Apr24.1%71.4%7
May2.5%66.7%6
Jun4.5%57.1%7
Jul16.0%71.4%7
Aug8.5%57.1%7
Sep1.2%57.1%7
Oct-13.1%14.3%7
Nov15.3%57.1%7
Dec-8.7%28.6%7

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.40% 50.2% 331
Tuesday -0.33% 43.6% 367
Wednesday 0.16% 45.0% 362
Thursday 0.56% 45.2% 354
Friday -0.24% 46.9% 356

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 25.0%

Insider Transactions — Smart Summary

Total insider ownership: 2.5%

12-Month Insider Activity Summary

Total Filings7
Net Value-$1.2M
Net Shares Change303,921
% of Float2.2%
C-Suite Filings7
Clusters Detected1

Key Insiders

NameTitleNet ValueFilingsActivity
Oliveto Joseph President and CEO -$555,687.207 3 1 sell
Nelson Jeffrey Edward Chief Operating Officer -$158,207.504 1 1 sell
Hasija Amit CFO and EVP of Corp. Development -$158,207.504 1 1 sell
Bharucha David Chief Medical Officer -$158,207.504 1 1 sell
Muller Lorenz Chief Commercial Officer -$145,853.314 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-01-28 – 2026-01-28 5 5 -$995,798.033 5 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-01-28 Oliveto Joseph President and CEO -$375,322.207 Transaction at $2.24, now -37.5%
2026-01-28 Nelson Jeffrey Edward Chief Operating Officer -$158,207.504 Transaction at $2.25, now -37.8%
2026-01-28 Muller Lorenz Chief Commercial Officer -$145,853.314 Transaction at $2.25, now -37.9%
2026-01-28 Hasija Amit CFO and EVP of Corp. Development -$158,207.504 Transaction at $2.25, now -37.8%
2026-01-28 Bharucha David Chief Medical Officer -$158,207.504 Transaction at $2.25, now -37.8%
2026-04-20 Oliveto Joseph President and CEO -$82,490 Transaction at $2.26, now -38.1%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Milestone Pharmaceuticals Inc (MIST) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for MIST on Trend Edge →