Short Squeeze Setup — velZ +1.20 · age 82w×0.45 · 25.46%
Founder-Led — founder/CEO led
About Madrigal Pharmaceuticals Inc
Madrigal Pharmaceuticals, Inc., a biopharmaceutical company, focuses on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) in the United States. It offers Rezdiffra, a liver-directed thyroid hormone receptor beta agonist for treating MASH. The company was founded in 2016 and is headquartered in West Conshohocken, Pennsylvania.… Read full Trend Edge analysis →
Sector: Healthcare
Industry: Biotechnology
Exchange: NASDAQ
IPO Date: February 6, 2007
Headquarters: Four Tower Bridge, West Conshohocken, PA, United States, 19428
Founder-Led: Yes — Rebecca Taub (Founder and Senior Scientific and Medical Advisor and Director)
Key Metrics
Current Price
$544.51
Market Cap
$12.53B
Float
13.8M
Shares Outstanding
23.1M
P/E (Forward)
666.67
Price/Sales (TTM)
11.06
vs. Analyst Target
+24.7% to analyst PT
Profit Margin
-27.32%
Operating Margin (TTM)
-29.78%
Revenue (TTM)
$1.13B
Dividend Rate
None
Analyst Target Price
$678.86 (15 analysts)
Financial History
Annual Revenue & Earnings History
Year
Revenue
Net Income
Gross Profit
EBITDA
2020
$21,864
-$197M
$21,864
-$206M
2021
$37,318
-$241M
$273,000
-$242M
2022
N/A
-$295M
-$467,000
-$291M
2023
N/A
-$374M
-$527,000
-$360M
2024
$180M
-$466M
$174M
-$450M
2025
$958M
-$288M
$902M
-$264M
Recent Quarterly Revenue & Net Income
Quarter
Revenue
Net Income
Jun 2025
$213M
-$42.3M
Sep 2025
$287M
-$114M
Dec 2025
$321M
-$58.6M
Mar 2026
$311M
-$94.4M
Ownership & Float
Insider Ownership
5.9%
Institutional Ownership
107.1%
Short Float
25.5%
% of All Funds Holding
4.26%
Number of Funds Holding
350
Current Moving Averages
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
Timeframe
SMA
Value
Trend Context
Weekly
10-Week SMA
$516.35
Near-term / short-term trend
Weekly
40-Week SMA
$509.56
Medium-term trend
Weekly
80-Week SMA
$425.72
Cyclical trend (business cycle)
Weekly
200-Week SMA
$305.72
Secular trend (multi-year)
Monthly
10-Month SMA
$513.91
Near-term monthly trend
Monthly
20-Month SMA
$428.29
Medium-term monthly trend
Monthly
40-Month SMA
$331.41
Secular monthly trend
Volume Shelves — Support & Resistance
Trend Edge identifies volume shelves: price zones where historically elevated trading volume
creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative
volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
Price Level
Type
Volume Ratio
Age
$431.00
support
1.08x
3 months ago
$422.00
support
1.13x
7 months ago
$299.00
support
1.15x
10 months ago
$275.00
support
1.31x
19 months ago
Historical Earnings Reactions (78 events)
Timeframe
Avg Return
Median
Win Rate
Best
Worst
Gap
0.57%
0.16%
51.28%
16.52%
-12.50%
1 Day
-0.06%
-0.42%
38.46%
23.23%
-13.83%
1 Week
1.25%
0.77%
52.56%
41.31%
-33.85%
2 Weeks
1.09%
-0.92%
48.72%
47.49%
-43.38%
1 Month
6.96%
1.01%
54.55%
134.63%
-52.49%
Next earnings: July 30, 2026 (4 days away)
Seasonality & Day-of-Week Patterns
Monthly Seasonality
Month
Avg Return
Win Rate
Samples
Jan
1.4%
47.4%
19
Feb
-0.7%
63.2%
19
Mar
-0.9%
35.0%
20
Apr
7.5%
55.0%
20
May
4.6%
35.0%
20
Jun
-4.7%
45.0%
20
Jul
1.1%
31.6%
19
Aug
2.3%
47.4%
19
Sep
7.2%
47.4%
19
Oct
-0.9%
47.4%
19
Nov
6.4%
63.2%
19
Dec
23.1%
52.6%
19
Day-of-Week Tendencies
Day
Avg Return
Win Rate
Samples
Monday
0.54%
48.9%
919
Tuesday
-0.01%
47.0%
1005
Wednesday
-0.13%
45.8%
1004
Thursday
0.32%
47.5%
985
Friday
0.19%
48.5%
979
Top Institutional Holders
Institutional holder breakdown coming soon.
Total institutional ownership: 107.1%
Insider Transactions — Smart Summary
Total insider ownership: 5.9%
Founder-led management: Rebecca Taub (Founder and Senior Scientific and Medical Advisor and Director)
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The analysis covers five layers:
technical analysis (near-term, medium-term, cyclical, and secular trend, momentum,
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qualitative analysis (business model, competitive moat, sector dynamics),
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share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and
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