Stock analysis, trade plans, and proprietary indicators by Trend Edge.
Trend Edge Setup Score
Trend Edge rates MDGL Bullish with a Setup Score of 87, net conviction 54, actionability 141. How the Setup Score works →
Total Setup Score
87
Directional Bias
Bullish
Net Conviction
54
Actionability
141 (in range)
Key signals behind this score
Fresh Trend Turn — aligned 11w
80wk Uptrend — trend only (sma 454 vs px 453)
200wk Uptrend — rising+above (sma 333 vs px 453)
Funds Accumulating — momZ +2.51 · 4.21→4.70
Short Squeeze Setup — velZ +1.88 · age 94w×0.45 · 16.33%
Founder-Led — founder/CEO led
About Madrigal Pharmaceuticals Inc
Madrigal Pharmaceuticals, Inc., a biopharmaceutical company, focuses on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) in the United States. It offers Rezdiffra, a liver-directed thyroid hormone receptor beta agonist for treating MASH. The company was founded in 2016 and is headquartered in West Conshohocken, Pennsylvania.… Read full Trend Edge analysis →
Sector: Healthcare
Industry: Biotechnology
Exchange: NASDAQ
IPO Date: February 6, 2007
Headquarters: 1001 Conshohocken State Road, West Conshohocken, PA, United States, 19428
Founder-Led: Yes — Rebecca Taub (Founder and Senior Scientific and Medical Advisor and Director)
Key Metrics
Current Price
$453.34
Market Cap
$10.62B
Float
13.7M
Shares Outstanding
23.1M
P/E (Forward)
78.13
Price/Sales (TTM)
8.27
vs. Analyst Target
+51.3% to analyst PT
Profit Margin
-25.32%
Operating Margin (TTM)
-15.46%
Revenue (TTM)
$1.28B
Dividend Rate
None
Analyst Target Price
$685.78 (19 analysts)
Financial History
Annual Revenue & Earnings History
Year
Revenue
Net Income
Gross Profit
EBITDA
2020
N/A
-$197M
-$471,000
-$206M
2021
N/A
-$241M
N/A
-$242M
2022
N/A
-$295M
N/A
-$291M
2023
N/A
-$374M
N/A
-$360M
2024
$180M
-$466M
$174M
-$450M
2025
$958M
-$288M
$902M
-$264M
Recent Quarterly Revenue & Net Income
Quarter
Revenue
Net Income
Sep 2025
$287M
-$114M
Dec 2025
$321M
-$58.6M
Mar 2026
$311M
-$94.4M
Jun 2026
$364M
-$57.9M
Ownership & Float
Insider Ownership
5.8%
Institutional Ownership
104.3%
Short Float
17.5%
% of All Funds Holding
4.70%
Number of Funds Holding
413
Current Moving Averages
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
Timeframe
SMA
Value
Trend Context
Weekly
10-Week SMA
$504.84
Near-term / short-term trend
Weekly
40-Week SMA
$499.09
Medium-term trend
Weekly
80-Week SMA
$453.83
Cyclical trend (business cycle)
Weekly
200-Week SMA
$332.83
Secular trend (multi-year)
Monthly
10-Month SMA
$496.10
Near-term monthly trend
Monthly
20-Month SMA
$450.07
Medium-term monthly trend
Monthly
40-Month SMA
$346.38
Secular monthly trend
Volume Shelves — Support & Resistance
Trend Edge identifies volume shelves: price zones where historically elevated trading volume
creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative
volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
Price Level
Type
Volume Ratio
Age
$431.00
support
1.08x
6 months ago
$422.00
support
1.13x
10 months ago
$299.00
support
1.15x
13 months ago
$275.00
support
1.31x
22 months ago
Historical Earnings Reactions (79 events)
Timeframe
Avg Return
Median
Win Rate
Best
Worst
Gap
0.55%
0.07%
50.63%
16.52%
-12.50%
1 Day
-0.12%
-0.43%
37.97%
23.23%
-13.83%
1 Week
1.27%
0.81%
53.16%
41.31%
-33.85%
2 Weeks
1.11%
-0.92%
49.37%
47.49%
-43.38%
1 Month
6.72%
1.00%
53.85%
134.63%
-52.49%
Next earnings: November 3, 2026 (10 days away)
Seasonality & Day-of-Week Patterns
Monthly Seasonality
Month
Avg Return
Win Rate
Samples
Jan
1.4%
47.4%
19
Feb
-0.7%
63.2%
19
Mar
-0.9%
35.0%
20
Apr
7.5%
55.0%
20
May
4.6%
35.0%
20
Jun
-4.7%
45.0%
20
Jul
0.4%
30.0%
20
Aug
2.9%
50.0%
20
Sep
6.5%
45.0%
20
Oct
-0.9%
47.4%
19
Nov
6.4%
63.2%
19
Dec
23.1%
52.6%
19
Day-of-Week Tendencies
Day
Avg Return
Win Rate
Samples
Monday
0.54%
49.0%
931
Tuesday
-0.01%
46.9%
1018
Wednesday
-0.11%
46.1%
1017
Thursday
0.29%
47.3%
998
Friday
0.18%
48.3%
992
Top Institutional Holders
Institutional holder breakdown coming soon.
Total institutional ownership: 104.3%
Insider Transactions — Smart Summary
Total insider ownership: 5.8%
Founder-led management: Rebecca Taub (Founder and Senior Scientific and Medical Advisor and Director)
Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Madrigal Pharmaceuticals Inc
(MDGL) powered by Claude Opus — Anthropic's most capable AI model.
The analysis covers five layers:
technical analysis (near-term, medium-term, cyclical, and secular trend, momentum,
volume shelf support and resistance, breakout and breakdown signals),
qualitative analysis (business model, competitive moat, sector dynamics),
insider sentiment (buy and sell signals from executive and director transactions),
share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and
fundamental analysis (valuation, revenue growth, profit margin, earnings quality).
AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit,
stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward.
Whether you are building a long position, initiating a short, or looking for a reversal setup,
AI Consult identifies the highest-probability signal from the current trend.