Short Squeeze Setup — velZ +2.96 · age 88w×0.45 · 14.32%
Founder-Led — founder/CEO led
About Madrigal Pharmaceuticals Inc
Madrigal Pharmaceuticals, Inc., a biopharmaceutical company, focuses on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) in the United States. It offers Rezdiffra, a liver-directed thyroid hormone receptor beta agonist for treating MASH. The company was founded in 2016 and is headquartered in West Conshohocken, Pennsylvania.… Read full Trend Edge analysis →
Sector: Healthcare
Industry: Biotechnology
Exchange: NASDAQ
IPO Date: February 6, 2007
Headquarters: 1001 Conshohocken State Road, West Conshohocken, PA, United States, 19428
Founder-Led: Yes — Rebecca Taub (Founder and Senior Scientific and Medical Advisor and Director)
Key Metrics
Current Price
$541.08
Market Cap
$12.54B
Float
13.7M
Shares Outstanding
23.1M
P/E (Forward)
81.97
Price/Sales (TTM)
9.76
vs. Analyst Target
+25.3% to analyst PT
Profit Margin
-25.32%
Operating Margin (TTM)
-15.46%
Revenue (TTM)
$1.28B
Dividend Rate
None
Analyst Target Price
$678.06 (15 analysts)
Financial History
Annual Revenue & Earnings History
Year
Revenue
Net Income
Gross Profit
EBITDA
2020
N/A
-$197M
-$471,000
-$206M
2021
N/A
-$241M
N/A
-$242M
2022
N/A
-$295M
N/A
-$291M
2023
N/A
-$374M
N/A
-$360M
2024
$180M
-$466M
$174M
-$450M
2025
$958M
-$288M
$902M
-$264M
Recent Quarterly Revenue & Net Income
Quarter
Revenue
Net Income
Sep 2025
$287M
-$114M
Dec 2025
$321M
-$58.6M
Mar 2026
$311M
-$94.4M
Jun 2026
$364M
-$57.9M
Ownership & Float
Insider Ownership
5.9%
Institutional Ownership
104.4%
Short Float
14.8%
% of All Funds Holding
4.70%
Number of Funds Holding
413
Current Moving Averages
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
Timeframe
SMA
Value
Trend Context
Weekly
10-Week SMA
$523.93
Near-term / short-term trend
Weekly
40-Week SMA
$511.38
Medium-term trend
Weekly
80-Week SMA
$439.64
Cyclical trend (business cycle)
Weekly
200-Week SMA
$319.04
Secular trend (multi-year)
Monthly
10-Month SMA
$512.72
Near-term monthly trend
Monthly
20-Month SMA
$446.32
Medium-term monthly trend
Monthly
40-Month SMA
$341.75
Secular monthly trend
Volume Shelves — Support & Resistance
Trend Edge identifies volume shelves: price zones where historically elevated trading volume
creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative
volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
Price Level
Type
Volume Ratio
Age
$431.00
support
1.08x
5 months ago
$422.00
support
1.13x
9 months ago
$299.00
support
1.15x
12 months ago
$275.00
support
1.31x
21 months ago
Historical Earnings Reactions (79 events)
Timeframe
Avg Return
Median
Win Rate
Best
Worst
Gap
0.55%
0.07%
50.63%
16.52%
-12.50%
1 Day
-0.12%
-0.43%
37.97%
23.23%
-13.83%
1 Week
1.27%
0.81%
53.16%
41.31%
-33.85%
2 Weeks
1.11%
-0.92%
49.37%
47.49%
-43.38%
1 Month
6.72%
1.00%
53.85%
134.63%
-52.49%
Next earnings: October 18, 2026 (39 days away)
Seasonality & Day-of-Week Patterns
Monthly Seasonality
Month
Avg Return
Win Rate
Samples
Jan
1.4%
47.4%
19
Feb
-0.7%
63.2%
19
Mar
-0.9%
35.0%
20
Apr
7.5%
55.0%
20
May
4.6%
35.0%
20
Jun
-4.7%
45.0%
20
Jul
0.4%
30.0%
20
Aug
2.9%
50.0%
20
Sep
7.2%
47.4%
19
Oct
-0.9%
47.4%
19
Nov
6.4%
63.2%
19
Dec
23.1%
52.6%
19
Day-of-Week Tendencies
Day
Avg Return
Win Rate
Samples
Monday
0.54%
49.1%
925
Tuesday
0.00%
47.1%
1011
Wednesday
-0.12%
46.0%
1010
Thursday
0.30%
47.4%
991
Friday
0.18%
48.4%
985
Top Institutional Holders
Institutional holder breakdown coming soon.
Total institutional ownership: 104.4%
Insider Transactions — Smart Summary
Total insider ownership: 5.9%
Founder-led management: Rebecca Taub (Founder and Senior Scientific and Medical Advisor and Director)
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The analysis covers five layers:
technical analysis (near-term, medium-term, cyclical, and secular trend, momentum,
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qualitative analysis (business model, competitive moat, sector dynamics),
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share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and
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