LXRX — Lexicon Pharmaceuticals Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates LXRX Bullish with a Setup Score of 25, net conviction 29, actionability 22. How the Setup Score works →

Total Setup Score25
Directional BiasBullish
Net Conviction29
Actionability22 (in range)

Key signals behind this score

About Lexicon Pharmaceuticals Inc

Lexicon Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of pharmaceutical products for the treatment of human disease. The company develops sotagliflozin, an orally-delivered small molecule drug for the treatment of hypertrophic cardiomyopathy, and ZYNQUISTA (sotagliflozin) for the treatment of type 1 diabetes. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$2.22
Market Cap$999M
Float262.5M
Shares Outstanding444.2M
Price/Sales (TTM)14.48
vs. Analyst Target+69.8% to analyst PT
Profit Margin-37.46%
Operating Margin (TTM)-4.72%
Revenue (TTM)$69.6M
Earnings Growth (YoY)-63.40%
Dividend RateNone
Analyst Target Price$3.77 (5 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $24.0M -$58.6M $22.1M -$41.1M
2021 $298,000 -$87.8M -$54.7M -$86.7M
2022 $139,000 -$102M -$52.4M -$100M
2023 $1.2M -$177M -$57.8M -$170M
2024 $31.1M -$200M $30.5M -$184M
2025 $49.8M -$50.3M $49.5M -$41.4M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $28.9M $3.3M
Sep 2025 $14.2M -$12.8M
Dec 2025 $5.5M -$15.5M
Mar 2026 $21.1M -$1.0M

Ownership & Float

Insider Ownership1.1%
Institutional Ownership78.5%
Short Float9.7%
% of All Funds Holding1.57%
Number of Funds Holding129

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$2.15Near-term / short-term trend
Weekly40-Week SMA$1.62Medium-term trend
Weekly80-Week SMA$1.23Cyclical trend (business cycle)
Weekly200-Week SMA$1.63Secular trend (multi-year)
Monthly10-Month SMA$1.66Near-term monthly trend
Monthly20-Month SMA$1.25Medium-term monthly trend
Monthly40-Month SMA$1.54Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$1.60 support 1.25x 1 months ago
$0.50 support 1.34x 14 months ago

Historical Earnings Reactions (104 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.58% 0.00% 37.50% 6.75% -15.84%
1 Day -0.69% -0.55% 46.15% 22.94% -19.44%
1 Week -0.93% -1.85% 39.42% 34.67% -31.93%
2 Weeks -3.14% -3.17% 32.69% 28.57% -33.08%
1 Month -1.15% -2.48% 45.63% 52.77% -35.29%

Next earnings: August 5, 2026 (23 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan4.1%53.8%26
Feb-4.7%42.3%26
Mar-1.7%46.2%26
Apr1.4%46.2%26
May4.0%51.9%27
Jun13.5%66.7%27
Jul2.1%53.8%26
Aug-2.5%26.9%26
Sep1.1%34.6%26
Oct-0.8%57.7%26
Nov-4.1%38.5%26
Dec6.2%46.2%26

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.07% 44.5% 1239
Tuesday 0.14% 44.6% 1354
Wednesday 0.13% 46.1% 1354
Thursday -0.02% 45.7% 1328
Friday 0.24% 47.1% 1322

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 78.5%

Insider Transactions — Smart Summary

Total insider ownership: 1.1%

12-Month Insider Activity Summary

Total Filings5
Net Value+N/A
Net Shares Change24,826,104
% of Float9.5%
C-Suite Filings0
Clusters Detected0

Key Insiders

NameTitleNet ValueFilingsActivity
Invus Global Management, LLC +$2.0M 1 1 buy
DEBBANE RAYMOND +$722,615.607 4 4 buy

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-02-04 Invus Global Management, LLC +$2.0M Transaction at $1.30, now +70.8%
2026-02-27 DEBBANE RAYMOND +$2,980 Transaction at $1.49, now +49.0%
2026-02-25 DEBBANE RAYMOND +$147,000 Transaction at $1.47, now +51.0%
2026-02-23 DEBBANE RAYMOND +$219,750 Transaction at $1.47, now +51.5%
2026-02-18 DEBBANE RAYMOND +$352,885.607 Transaction at $1.31, now +68.9%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Lexicon Pharmaceuticals Inc (LXRX) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for LXRX on Trend Edge →