Stock analysis, trade plans, and proprietary indicators by Trend Edge.
Trend Edge Setup Score
Trend Edge rates KPTI Bearish with a Setup Score of 0, net conviction 53, actionability 0. How the Setup Score works →
Total Setup Score
0
Directional Bias
Bearish
Net Conviction
53
Actionability
0 (extended)
Key signals behind this score
40wk Downtrend — falling+below (sma 7.24 vs px 1.92)
80wk Downtrend — falling+below (sma 6.38 vs px 1.92)
200wk Downtrend — falling+below (sma 17.93 vs px 1.92)
Short Attack — velZ +3.19 · age 34w×0.92 · 43.21%
RS Breakdown — momZ +0.67 · low 0w×1.00 · vs industry
About Karyopharm Therapeutics Inc
Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Read full Trend Edge analysis →
Sector: Healthcare
Industry: Biotechnology
Exchange: NASDAQ
IPO Date: November 6, 2013
Headquarters: 85 Wells Avenue, Newton, MA, United States, 02459-3298
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
Timeframe
SMA
Value
Trend Context
Weekly
10-Week SMA
$5.70
Near-term / short-term trend
Weekly
40-Week SMA
$7.24
Medium-term trend
Weekly
80-Week SMA
$6.38
Cyclical trend (business cycle)
Weekly
200-Week SMA
$17.93
Secular trend (multi-year)
Monthly
10-Month SMA
$6.55
Near-term monthly trend
Monthly
20-Month SMA
$6.25
Medium-term monthly trend
Monthly
40-Month SMA
$11.51
Secular monthly trend
Volume Shelves — Support & Resistance
Trend Edge identifies volume shelves: price zones where historically elevated trading volume
creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative
volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Karyopharm Therapeutics Inc
(KPTI) powered by Claude Opus — Anthropic's most capable AI model.
The analysis covers five layers:
technical analysis (near-term, medium-term, cyclical, and secular trend, momentum,
volume shelf support and resistance, breakout and breakdown signals),
qualitative analysis (business model, competitive moat, sector dynamics),
insider sentiment (buy and sell signals from executive and director transactions),
share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and
fundamental analysis (valuation, revenue growth, profit margin, earnings quality).
AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit,
stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward.
Whether you are building a long position, initiating a short, or looking for a reversal setup,
AI Consult identifies the highest-probability signal from the current trend.