200wk Uptrend — rising+above (sma 2.55 vs px 3.92)
Funds Accumulating — momZ +3.23 · 0.66→0.88
Founder-Led — founder/CEO led
About Opus Genetics, Inc.
Opus Genetics, Inc., a clinical-stage biopharmaceutical company, develops gene therapies to restore vision and prevent blindness in patients with inherited retinal diseases (IRDs) and other types of therapies for additional ophthalmic disorders. It develops OPGx-LCA5, an early-onset retinal degeneration that is in Phase 1/2 clinical trial for the treatment of LCA5-associated IRD; and OPGx-BEST1 to treat BEST1-associated retinal disease. Read full Trend Edge analysis →
Sector: Healthcare
Industry: Biotechnology
Exchange: NASDAQ
IPO Date: May 23, 2005
Headquarters: 8 Davis Drive, Durham, NC, United States, 27713
Founder-Led: Yes — Ben Yerxa (President and Director)
Key Metrics
Current Price
$3.92
Market Cap
$339M
Float
63.4M
Shares Outstanding
82.6M
P/E (Forward)
12.00
Price/Sales (TTM)
27.70
vs. Analyst Target
+169.3% to analyst PT
Operating Margin (TTM)
-665.93%
Revenue (TTM)
$12.0M
Dividend Rate
None
Analyst Target Price
$10.56 (3 analysts)
Financial History
Annual Revenue & Earnings History
Year
Revenue
Net Income
Gross Profit
EBITDA
2020
N/A
-$24.6M
-$8,000
-$17.8M
2021
$589,000
-$56.7M
$589,000
-$56.7M
2022
$39.9M
$17.9M
$39.9M
$18.2M
2023
$19.0M
-$10.0M
$19.0M
-$10.0M
2024
$11.0M
-$57.5M
$11.0M
-$57.5M
2025
$14.2M
-$49.6M
$14.2M
-$48.1M
Recent Quarterly Revenue & Net Income
Quarter
Revenue
Net Income
Jun 2025
$2.9M
-$7.4M
Sep 2025
$3.1M
-$17.5M
Dec 2025
$3.9M
-$16.5M
Mar 2026
$2.2M
-$65.5M
Ownership & Float
Insider Ownership
11.1%
Institutional Ownership
55.1%
Short Float
9.0%
% of All Funds Holding
0.88%
Number of Funds Holding
72
Current Moving Averages
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
Timeframe
SMA
Value
Trend Context
Weekly
10-Week SMA
$4.27
Near-term / short-term trend
Weekly
40-Week SMA
$3.43
Medium-term trend
Weekly
80-Week SMA
$2.28
Cyclical trend (business cycle)
Weekly
200-Week SMA
$2.55
Secular trend (multi-year)
Monthly
10-Month SMA
$3.50
Near-term monthly trend
Monthly
20-Month SMA
$2.31
Medium-term monthly trend
Monthly
40-Month SMA
$2.47
Secular monthly trend
Volume Shelves — Support & Resistance
Trend Edge identifies volume shelves: price zones where historically elevated trading volume
creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative
volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
Price Level
Type
Volume Ratio
Age
$5.10
resistance
1.34x
1 months ago
$2.30
support
1.49x
4 months ago
$1.70
support
1.07x
8 months ago
Historical Earnings Reactions (69 events)
Timeframe
Avg Return
Median
Win Rate
Best
Worst
Gap
-0.33%
0.00%
44.93%
19.39%
-39.60%
1 Day
-1.56%
-1.42%
28.99%
15.31%
-38.61%
1 Week
-2.28%
-1.43%
37.68%
40.21%
-37.62%
2 Weeks
-0.46%
-1.65%
39.13%
76.92%
-38.61%
1 Month
-0.37%
-3.57%
39.71%
84.62%
-48.51%
Next earnings: August 12, 2026 (31 days away)
Seasonality & Day-of-Week Patterns
Monthly Seasonality
Month
Avg Return
Win Rate
Samples
Jan
11.5%
47.6%
21
Feb
9.7%
52.4%
21
Mar
1.0%
38.1%
21
Apr
-1.1%
38.1%
21
May
5.6%
52.4%
21
Jun
-3.8%
33.3%
21
Jul
-1.3%
35.0%
20
Aug
-1.0%
40.0%
20
Sep
0.3%
50.0%
20
Oct
-8.1%
30.0%
20
Nov
-6.3%
30.0%
20
Dec
-0.3%
42.9%
21
Day-of-Week Tendencies
Day
Avg Return
Win Rate
Samples
Monday
0.05%
36.9%
973
Tuesday
0.15%
37.1%
1066
Wednesday
0.06%
38.9%
1066
Thursday
0.24%
38.6%
1045
Friday
0.09%
35.4%
1041
Top Institutional Holders
Institutional holder breakdown coming soon.
Total institutional ownership: 55.1%
Insider Transactions — Smart Summary
Total insider ownership: 11.1%
Founder-led management: Ben Yerxa (President and Director)
12-Month Insider Activity Summary
Total Filings
13
Net Value
-$382,309.059
Net Shares Change
-5,576,395
% of Float
-8.8%
C-Suite Filings
10
Clusters Detected
2
Key Insiders
Name
Title
Net Value
Filings
Activity
Foundation Fighting Blindness Retinal Degeneration Fund
-$16.0M
2
2 sell
Gallagher Cam
+$323,693.4
1
2 buy
Magrath George
Chief Executive Officer
-$49,647.42
1
N/A
Gagnon Robert E.
Chief Financial Officer
-$40,657.633
1
N/A
Jayagopal Ashwath
Chief Scientific & Dev. Ofc.
-$39,155.801
1
N/A
YERXA BENJAMIN R
President
-$39,121.137
1
N/A
SCHACHLE JOSEPH K
Chief Operating Officer
-$24,519.279
1
N/A
Zaremba Rabourn Amy
Head of Fin. Quality Assurance
-$23,309.684
2
N/A
Transaction Clusters
Period
Filings
Insiders
Net Value
Seniority
2026-03-18 – 2026-03-18
4
4
-$180,668.024
4 C-suite
2026-04-27 – 2026-04-27
6
6
-$201,641.035
6 C-suite
Significant Filings
Date
Insider
Title
Net Value
Price After
2025-12-31
Gallagher Cam
+$323,693.4
Transaction at $1.97, now +98.6%
2026-05-20
Foundation Fighting Blindness Retinal Degeneration Fund
-$7.4M
Transaction at $4.35, now -9.9%
2025-12-11
Foundation Fighting Blindness Retinal Degeneration Fund
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