IONS — Ionis Pharmaceuticals Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates IONS Bullish with a Setup Score of 30, net conviction 27, actionability 34. How the Setup Score works →

Total Setup Score30
Directional BiasBullish
Net Conviction27
Actionability34 (in range)

Key signals behind this score

About Ionis Pharmaceuticals Inc

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; DAWNZERA for prophylaxis to prevent attacks of hereditary angioedema in adults; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) i… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$62.04
Market Cap$9.76B
Float164.9M
Shares Outstanding166.2M
P/E (Forward)90.91
Price/Sales (TTM)11.17
vs. Analyst Target+41.8% to analyst PT
Profit Margin-64.66%
Operating Margin (TTM)-38.18%
Revenue (TTM)$874M
Earnings Growth (YoY)-43.70%
Dividend RateNone
Analyst Target Price$88.00 (26 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $729M -$487M $717M -$155M
2021 $810M -$28.6M $800M -$5.2M
2022 $587M -$270M $573M -$228M
2023 $788M -$366M $779M -$236M
2024 $705M -$454M $694M -$354M
2025 $944M -$381M $928M -$287M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 $157M -$129M
Dec 2025 $203M -$229M
Mar 2026 $246M -$92.5M
Jun 2026 $268M -$115M

Ownership & Float

Insider Ownership0.6%
Institutional Ownership110.3%
Short Float13.0%
% of All Funds Holding5.79%
Number of Funds Holding509

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$61.95Near-term / short-term trend
Weekly40-Week SMA$73.53Medium-term trend
Weekly80-Week SMA$59.68Cyclical trend (business cycle)
Weekly200-Week SMA$48.78Secular trend (multi-year)
Monthly10-Month SMA$74.51Near-term monthly trend
Monthly20-Month SMA$58.47Medium-term monthly trend
Monthly40-Month SMA$50.89Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$79.00 resistance 1.93x 0 months ago
$50.00 support 1.80x 10 months ago

Historical Earnings Reactions (125 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.17% 0.11% 53.60% 10.56% -8.33%
1 Day 0.29% 0.00% 49.60% 13.88% -10.23%
1 Week -0.08% -0.59% 46.40% 26.89% -18.37%
2 Weeks 0.48% 0.08% 50.40% 32.73% -28.22%
1 Month 3.07% 1.18% 55.65% 57.87% -45.28%

Next earnings: October 17, 2026 (53 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan4.6%62.9%35
Feb-1.6%34.3%35
Mar-2.1%34.3%35
Apr-0.0%40.0%35
May2.8%48.6%35
Jun3.7%61.1%36
Jul-0.7%50.0%36
Aug3.9%54.3%35
Sep3.7%42.9%35
Oct-0.4%40.0%35
Nov7.4%62.9%35
Dec0.8%60.0%35

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.04% 46.8% 1672
Tuesday 0.04% 45.2% 1824
Wednesday 0.14% 47.2% 1820
Thursday 0.14% 47.0% 1786
Friday 0.13% 47.4% 1776

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 110.3%

Insider Transactions — Smart Summary

Total insider ownership: 0.6%

12-Month Insider Activity Summary

Total Filings101
Net Value-$65.2M
Net Shares Change-128,362
% of Float-0.1%
C-Suite Filings76
Clusters Detected12

Key Insiders

NameTitleNet ValueFilingsActivity
Monia Brett P Chief Executive Officer -$8.5M 2 2 sell
Baroldi Joseph EVP, Chief Business Officer -$1.5M 3 4 sell
Swayze Eric EVP Research -$1.3M 2 3 sell
Hayden Michael R +$1.1M 1 1 buy
Jenne Kyle EVP, Chf GL Pdt Str Ofcr -$368,488.242 1 1 sell
Birchler Brian EVP, Corp and Development Ops -$73,015.866 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-08-26 – 2025-09-09 15 13 -$16.0M 10 C-suite
2025-09-30 – 2025-10-08 11 7 -$5.0M 10 C-suite
2025-10-16 – 2025-10-16 4 4 -$1.0M 3 C-suite
2025-11-03 – 2025-11-07 5 4 -$3.7M 3 C-suite
2025-11-20 – 2025-12-03 4 4 -$4.3M 1 C-suite
2026-01-20 – 2026-02-02 20 11 -$18.5M 20 C-suite
2026-02-09 – 2026-02-13 3 3 -$4.2M 2 C-suite
2026-03-05 – 2026-03-18 10 10 -$20.7M 7 C-suite
2026-03-23 – 2026-04-02 3 3 -$1.7M 2 C-suite
2026-04-17 – 2026-04-30 5 4 -$1.4M 4 C-suite
2026-05-04 – 2026-05-15 3 3 -$2.5M 1 C-suite
2026-06-26 – 2026-07-09 9 9 -$7.2M 7 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-07-31 Hayden Michael R +$1.1M Transaction at $52.94, now +17.2%
2026-01-20 Swayze Eric EVP Research -$748,383.09 Transaction at $75.66, now -18.0%
2026-01-20 Baroldi Joseph EVP, Chief Business Officer -$610,276.47 Transaction at $75.77, now -18.1%
2026-04-17 Jenne Kyle EVP, Chf GL Pdt Str Ofcr -$368,488.242 Transaction at $75.17, now -17.5%
2026-04-17 Baroldi Joseph EVP, Chief Business Officer -$418,952.64 Transaction at $74.56, now -16.8%
2026-04-17 Birchler Brian EVP, Corp and Development Ops -$73,015.866 Transaction at $75.04, now -17.3%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Ionis Pharmaceuticals Inc (IONS) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for IONS on Trend Edge →