INSM — Insmed Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates INSM Bullish with a Setup Score of 0, net conviction 21, actionability 0. How the Setup Score works →

Total Setup Score0
Directional BiasBullish
Net Conviction21
Actionability0 (no mans land)

Key signals behind this score

About Insmed Inc

Insmed Incorporated develops and commercializes therapies for patients with serious and rare diseases in the United States, Europe, Japan, and internationally. The company offers ARIKAYCE for the treatment of refractory nontuberculous mycobacterial lung infections, as well as is in phase 3 clinical trial for the treatment of mycobacterium avium complex lung disease as part of a combination antibacterial drug regimen for adult patients. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$100.60
Market Cap$21.94B
Float216.9M
Shares Outstanding218.4M
P/E (Forward)97.09
Price/Sales (TTM)19.29
vs. Analyst Target+96.6% to analyst PT
Profit Margin-76.94%
Operating Margin (TTM)-23.81%
Revenue (TTM)$1.14B
Dividend RateNone
Analyst Target Price$197.74 (24 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $164M -$294M $125M -$250M
2021 $188M -$435M $144M -$384M
2022 $245M -$482M $190M -$447M
2023 $305M -$750M $240M -$660M
2024 $364M -$914M $278M -$819M
2025 $606M -$1.28B $482M -$1.17B

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 $142M -$370M
Dec 2025 $264M -$328M
Mar 2026 $306M -$164M
Jun 2026 $425M -$13.2M

Ownership & Float

Insider Ownership0.5%
Institutional Ownership105.0%
Short Float5.3%
% of All Funds Holding7.54%
Number of Funds Holding663

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$120.44Near-term / short-term trend
Weekly40-Week SMA$127.87Medium-term trend
Weekly80-Week SMA$128.20Cyclical trend (business cycle)
Weekly200-Week SMA$76.12Secular trend (multi-year)
Monthly10-Month SMA$125.47Near-term monthly trend
Monthly20-Month SMA$126.61Medium-term monthly trend
Monthly40-Month SMA$87.59Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$135.00 resistance 1.53x 4 months ago
$206.00 resistance 1.29x 9 months ago
$70.00 support 2.56x 15 months ago

Historical Earnings Reactions (105 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.44% 0.14% 51.43% 11.11% -6.51%
1 Day -0.19% -0.20% 45.71% 13.74% -16.30%
1 Week -0.27% -0.81% 48.57% 39.48% -31.66%
2 Weeks 0.68% -0.60% 45.71% 63.16% -32.23%
1 Month 5.41% 0.05% 50.00% 133.70% -38.97%

Next earnings: October 29, 2026 (18 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan7.5%50.0%26
Feb6.2%42.3%26
Mar-3.2%38.5%26
Apr7.3%46.2%26
May5.8%34.6%26
Jun3.8%57.7%26
Jul0.3%48.1%27
Aug-2.0%44.4%27
Sep4.8%55.6%27
Oct1.3%50.0%26
Nov5.5%61.5%26
Dec-0.9%42.3%26

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.09% 47.5% 1244
Tuesday 0.11% 45.1% 1359
Wednesday 0.16% 47.9% 1359
Thursday -0.00% 45.2% 1333
Friday 0.32% 45.5% 1329

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 105.0%

Insider Transactions — Smart Summary

Total insider ownership: 0.5%

12-Month Insider Activity Summary

Total Filings59
Net Value-$125M
Net Shares Change-275,399
% of Float-0.1%
C-Suite Filings53
Clusters Detected7

Key Insiders

NameTitleNet ValueFilingsActivity
Adsett Roger Chief Operating Officer -$28.0M 3 3 sell
Brennan David R -$3.1M 1 1 sell
Lewis William Chair and CEO -$1.5M 1 1 sell
Bonstein Sara Chief Financial Officer -$1.2M 2 2 sell
Smith Michael Alexander Chief Legal Officer -$698,184.55 2 2 sell
SHAROKY MELVIN MD -$637,650 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-11-05 – 2025-11-18 5 5 -$31.4M 3 C-suite
2025-11-26 – 2025-12-09 4 4 -$8.7M 2 C-suite
2026-01-06 – 2026-01-13 9 6 -$25.6M 9 C-suite
2026-01-22 – 2026-02-04 6 5 -$3.1M 6 C-suite
2026-03-20 – 2026-04-03 3 3 -$17.0M 3 C-suite
2026-05-06 – 2026-05-20 8 5 -$10.5M 8 C-suite
2026-05-22 – 2026-06-05 6 5 -$2.6M 6 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-09-11 Brennan David R -$3.1M Transaction at $124.00, now -18.9%
2026-08-12 Adsett Roger Chief Operating Officer -$27.1M Transaction at $76.86, now +30.9%
2026-08-19 SHAROKY MELVIN MD -$637,650 Transaction at $127.53, now -21.1%
2026-05-15 Bonstein Sara Chief Financial Officer -$961,040.96 Transaction at $116.18, now -13.4%
2026-06-05 Smith Michael Alexander Chief Legal Officer -$220,800.93 Transaction at $102.27, now -1.6%
2026-05-15 Smith Michael Alexander Chief Legal Officer -$477,383.62 Transaction at $116.18, now -13.4%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Insmed Inc (INSM) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for INSM on Trend Edge →