INSM — Insmed Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates INSM Bullish with a Setup Score of 26, net conviction 28, actionability 24. How the Setup Score works →

Total Setup Score26
Directional BiasBullish
Net Conviction28
Actionability24 (in range)

Key signals behind this score

About Insmed Inc

Insmed Incorporated develops and commercializes therapies for patients with serious and rare diseases in the United States, Europe, Japan, and internationally. The company offers ARIKAYCE for the treatment of refractory nontuberculous mycobacterial lung infections, as well as is in phase 3 clinical trial for the treatment of mycobacterium avium complex lung disease as part of a combination antibacterial drug regimen for adult patients. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$124.39
Market Cap$27.32B
Float216.9M
Shares Outstanding218.4M
P/E (Forward)16.37
Price/Sales (TTM)24.01
vs. Analyst Target+60.8% to analyst PT
Profit Margin-76.94%
Operating Margin (TTM)-23.81%
Revenue (TTM)$1.14B
Dividend RateNone
Analyst Target Price$200.05 (21 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $164M -$294M $125M -$250M
2021 $188M -$435M $144M -$384M
2022 $245M -$482M $190M -$447M
2023 $305M -$750M $240M -$660M
2024 $364M -$914M $278M -$819M
2025 $606M -$1.28B $482M -$1.17B

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 $142M -$370M
Dec 2025 $264M -$328M
Mar 2026 $306M -$164M
Jun 2026 $425M -$13.2M

Ownership & Float

Insider Ownership0.5%
Institutional Ownership104.9%
Short Float5.2%
% of All Funds Holding7.54%
Number of Funds Holding663

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$114.94Near-term / short-term trend
Weekly40-Week SMA$138.85Medium-term trend
Weekly80-Week SMA$125.36Cyclical trend (business cycle)
Weekly200-Week SMA$73.19Secular trend (multi-year)
Monthly10-Month SMA$142.44Near-term monthly trend
Monthly20-Month SMA$123.91Medium-term monthly trend
Monthly40-Month SMA$83.29Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$135.00 resistance 1.53x 2 months ago
$206.00 resistance 1.29x 7 months ago
$70.00 support 2.56x 13 months ago
$55.00 support 1.55x 25 months ago

Historical Earnings Reactions (105 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.44% 0.14% 51.43% 11.11% -6.51%
1 Day -0.19% -0.20% 45.71% 13.74% -16.30%
1 Week -0.27% -0.81% 48.57% 39.48% -31.66%
2 Weeks 0.68% -0.60% 45.71% 63.16% -32.23%
1 Month 5.41% 0.05% 50.00% 133.70% -38.97%

Next earnings: October 25, 2026 (59 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan7.5%50.0%26
Feb6.2%42.3%26
Mar-3.2%38.5%26
Apr7.3%46.2%26
May5.8%34.6%26
Jun3.8%57.7%26
Jul0.3%48.1%27
Aug-3.0%42.3%26
Sep5.2%57.7%26
Oct1.3%50.0%26
Nov5.5%61.5%26
Dec-0.9%42.3%26

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.09% 47.5% 1239
Tuesday 0.11% 45.3% 1353
Wednesday 0.15% 47.8% 1353
Thursday 0.00% 45.2% 1327
Friday 0.32% 45.6% 1323

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 104.9%

Insider Transactions — Smart Summary

Total insider ownership: 0.5%

12-Month Insider Activity Summary

Total Filings62
Net Value-$160M
Net Shares Change-293,891
% of Float-0.1%
C-Suite Filings56
Clusters Detected8

Key Insiders

NameTitleNet ValueFilingsActivity
Adsett Roger Chief Operating Officer -$28.0M 3 3 sell
Lewis William Chair and CEO -$2.3M 2 2 sell
Bonstein Sara Chief Financial Officer -$1.2M 2 2 sell
Smith Michael Alexander Chief Legal Officer -$698,184.55 2 2 sell
SHAROKY MELVIN MD -$637,650 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-09-04 – 2025-09-15 4 4 -$36.9M 3 C-suite
2025-11-05 – 2025-11-18 5 5 -$31.4M 3 C-suite
2025-11-26 – 2025-12-09 4 4 -$8.7M 2 C-suite
2026-01-06 – 2026-01-13 9 6 -$25.6M 9 C-suite
2026-01-22 – 2026-02-04 6 5 -$3.1M 6 C-suite
2026-03-20 – 2026-04-03 3 3 -$17.0M 3 C-suite
2026-05-06 – 2026-05-20 8 5 -$10.5M 8 C-suite
2026-05-22 – 2026-06-05 6 5 -$2.6M 6 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-08-12 Adsett Roger Chief Operating Officer -$27.1M Transaction at $76.86, now +61.8%
2026-06-05 Smith Michael Alexander Chief Legal Officer -$220,800.93 Transaction at $102.27, now +21.6%
2026-06-05 Bonstein Sara Chief Financial Officer -$245,857.08 Transaction at $102.27, now +21.6%
2026-06-05 Adsett Roger Chief Operating Officer -$242,379.9 Transaction at $102.27, now +21.6%
2026-08-19 SHAROKY MELVIN MD -$637,650 Transaction at $127.53, now -2.5%
2026-06-05 Lewis William Chair and CEO -$777,763.35 Transaction at $102.27, now +21.6%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Insmed Inc (INSM) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for INSM on Trend Edge →