FULC — Fulcrum Therapeutics Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates FULC Bearish with a Setup Score of 28, net conviction 36, actionability 22. How the Setup Score works →

Total Setup Score28
Directional BiasBearish
Net Conviction36
Actionability22 (in range)

Key signals behind this score

About Fulcrum Therapeutics Inc

Fulcrum Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops small molecules to improve the lives of patients with genetically defined diseases in the areas of high unmet medical need in the United States. Its clinical-stage product candidate is pociredir, a fetal hemoglobin inducer, which is in phase 1b clinical trial for the treatment of sickle cell disease and beta-thalassemia. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$3.50
Market Cap$239M
Float42.0M
Shares Outstanding66.6M
Price/Sales (TTM)5.46
vs. Analyst Target+66.7% to analyst PT
Dividend RateNone
Analyst Target Price$5.83 (7 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $8.8M -$68.4M $8.8M -$69.2M
2021 $19.2M -$78.3M $19.2M -$78.5M
2022 $6.3M -$110M -$70.4M -$110M
2023 $2.8M -$97.3M -$69.0M -$95.2M
2024 $80.0M -$9.7M $16.6M -$18.2M
2025 N/A -$74.9M -$1.4M -$73.5M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 N/A -$17.3M
Sep 2025 N/A -$19.6M
Dec 2025 N/A -$20.3M
Mar 2026 N/A -$18.9M

Ownership & Float

Insider Ownership3.8%
Institutional Ownership125.3%
Short Float13.2%
% of All Funds Holding1.85%
Number of Funds Holding152

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$4.92Near-term / short-term trend
Weekly40-Week SMA$8.25Medium-term trend
Weekly80-Week SMA$6.92Cyclical trend (business cycle)
Weekly200-Week SMA$6.42Secular trend (multi-year)
Monthly10-Month SMA$7.90Near-term monthly trend
Monthly20-Month SMA$6.71Medium-term monthly trend
Monthly40-Month SMA$6.20Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$7.00 resistance 3.77x 0 months ago

Historical Earnings Reactions (28 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.96% 0.19% 53.57% 26.00% -8.86%
1 Day 1.94% -0.80% 46.43% 28.31% -12.70%
1 Week 5.96% 0.83% 50.00% 83.51% -18.97%
2 Weeks 5.02% 3.46% 57.14% 60.73% -40.38%
1 Month 3.55% -4.38% 48.15% 71.07% -44.81%

Next earnings: August 4, 2026 (24 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan3.7%42.9%7
Feb-4.0%42.9%7
Mar-2.4%14.3%7
Apr-9.7%28.6%7
May15.1%57.1%7
Jun-9.8%28.6%7
Jul6.6%50.0%6
Aug41.3%42.9%7
Sep-8.7%42.9%7
Oct-9.8%14.3%7
Nov25.8%85.7%7
Dec18.8%100.0%7

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.15% 46.6% 328
Tuesday 0.60% 48.9% 362
Wednesday 0.44% 51.4% 358
Thursday -0.20% 46.2% 351
Friday 0.12% 48.3% 350

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 125.3%

Insider Transactions — Smart Summary

Total insider ownership: 3.8%

12-Month Insider Activity Summary

Total Filings6
Net Value-$44,599.84
Net Shares Change-4,241,591
% of Float-10.1%
C-Suite Filings1
Clusters Detected0

Key Insiders

NameTitleNet ValueFilingsActivity
RA CAPITAL MANAGEMENT, L.P. -$58.4M 1 1 sell
Gould Robert J -$489,441 3 N/A
Ezekowitz Alan -$65,613.6 1 N/A
Oltmans Curtis Gale Chief Legal Officer -$44,599.84 1 N/A

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-06-30 Ezekowitz Alan -$65,613.6 Transaction at $3.65, now -4.0%
2025-12-10 RA CAPITAL MANAGEMENT, L.P. -$58.4M Transaction at $13.98, now -75.0%
2025-12-17 Oltmans Curtis Gale Chief Legal Officer -$44,599.84 Transaction at $12.92, now -72.9%
2026-02-04 Gould Robert J -$163,089 Transaction at $10.87, now -67.8%
2026-02-04 Gould Robert J -$160,857 Transaction at $10.72, now -67.4%
2025-11-21 Gould Robert J -$165,495 Transaction at $11.03, now -68.3%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Fulcrum Therapeutics Inc (FULC) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for FULC on Trend Edge →