EXEL — Exelixis Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

About Exelixis Inc

Exelixis, Inc., an oncology company, focuses on the discovery, development, and commercialization of new medicines for difficult-to-treat cancers in the United States. The company offers CABOMETYX tablets for the treatment of patients with advanced renal cell carcinoma who received prior anti-angiogenic therapy; and COMETRIQ capsules for the treatment of progressive and metastatic medullary thyroid cancer. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$50.03
Market Cap$12.48B
Float206.3M
Shares Outstanding251.4M
P/E (Forward)15.80
P/E (TTM)16.44
Price/Sales (TTM)5.25
vs. Analyst Target-0.8% to analyst PT
Profit Margin35.08%
Operating Margin (TTM)41.15%
Revenue (TTM)$2.38B
Earnings Growth (YoY)43.60%
Dividend RateNone
Analyst Target Price$49.65 (20 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $988M $112M $951M $119M
2021 $1.43B $231M $1.38B $300M
2022 $1.61B $182M $1.55B $222M
2023 $1.83B $208M $1.76B $197M
2024 $2.17B $521M $2.09B $719M
2025 $2.32B $783M $2.24B $922M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $568M $185M
Sep 2025 $598M $194M
Dec 2025 $599M $245M
Mar 2026 $611M $210M

Ownership & Float

Insider Ownership1.8%
Institutional Ownership107.5%
Short Float14.5%
% of All Funds Holding7.92%
Number of Funds Holding651

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$46.17Near-term / short-term trend
Weekly40-Week SMA$42.80Medium-term trend
Weekly80-Week SMA$40.48Cyclical trend (business cycle)
Weekly200-Week SMA$28.82Secular trend (multi-year)
Monthly10-Month SMA$42.82Near-term monthly trend
Monthly20-Month SMA$40.12Medium-term monthly trend
Monthly40-Month SMA$30.91Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$32.80 support 1.12x 14 months ago
$26.00 support 1.22x 18 months ago
$23.60 support 1.13x 20 months ago

Historical Earnings Reactions (104 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.72% 0.06% 50.00% 19.13% -13.81%
1 Day 0.13% 0.00% 48.08% 20.84% -26.37%
1 Week 0.84% -0.73% 43.27% 60.78% -45.45%
2 Weeks 0.06% -0.83% 45.19% 66.27% -43.53%
1 Month -0.49% -0.32% 46.60% 64.43% -52.85%

Next earnings: July 24, 2026 (56 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan1.4%50.0%26
Feb2.3%50.0%26
Mar-1.1%50.0%26
Apr5.3%57.7%26
May0.4%46.2%26
Jun2.6%57.7%26
Jul4.2%53.8%26
Aug-1.0%46.2%26
Sep-3.7%46.2%26
Oct-0.6%53.8%26
Nov6.3%61.5%26
Dec5.2%61.5%26

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.15% 48.3% 1231
Tuesday 0.03% 48.7% 1348
Wednesday 0.19% 50.9% 1347
Thursday -0.08% 47.5% 1321
Friday 0.22% 52.0% 1317

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 107.5%

Insider Transactions — Smart Summary

Total insider ownership: 1.8%

12-Month Insider Activity Summary

Total Filings22
Net Value-$24.4M
Net Shares Change-828,997
% of Float-0.4%
C-Suite Filings10
Clusters Detected3

Key Insiders

NameTitleNet ValueFilingsActivity
Haley Patrick J. EVP, Commercial -$9.0M 3 4 sell
Senner Christopher J. EVP and CFO -$8.2M 2 2 sell
Aftab Dana EVP, Research and Development -$3.5M 2 2 sell
POSTE GEORGE -$2.7M 1 1 sell
Freire Maria C -$541,229.82 1 1 sell
Beckerle Mary C -$284,032.96 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-11-13 – 2025-11-26 5 5 -$9.2M 2 C-suite
2026-02-18 – 2026-02-26 9 8 -$21.2M 5 C-suite
2026-05-08 – 2026-05-22 6 6 -$9.7M 3 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-05-22 Haley Patrick J. EVP, Commercial -$1.6M Transaction at $49.81, now +0.4%
2026-05-19 Senner Christopher J. EVP and CFO -$3.8M Transaction at $50.55, now -1.0%
2026-05-08 POSTE GEORGE -$2.7M Transaction at $45.71, now +9.5%
2026-05-08 Beckerle Mary C -$284,032.96 Transaction at $35.84, now +39.6%
2026-05-08 Freire Maria C -$541,229.82 Transaction at $32.88, now +52.1%
2025-11-24 Haley Patrick J. EVP, Commercial -$3.0M Transaction at $42.17, now +18.6%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Exelixis Inc (EXEL) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for EXEL on Trend Edge →