Stock analysis, trade plans, and proprietary indicators by Trend Edge.
About Bicycle Therapeutics Ltd
Bicycle Therapeutics plc, a clinical-stage pharmaceutical company, develops a class of medicines for diseases that are underserved by existing therapeutics in the United States and the United Kingdom. The company's products pipeline include zelenectide pevedotin, a bicycle toxin conjugate (BTC), which is in phase II clinical trials for the treatment of high nectin-4 expressing tumors; nuzefatide pevedotin (EphA2), a BTC that is in phase I/II clin… Read full Trend Edge analysis →
Sector: Healthcare
Industry: Biotechnology
Exchange: NASDAQ
IPO Date: May 23, 2019
Headquarters: Portway Building, Cambridge, United Kingdom, CB21 6GS
Founder-Led: Yes — Christian Heinis (Scientific Founder)
Key Metrics
Current Price
$4.57
Market Cap
$309M
Float
1.9M
Shares Outstanding
50.4M
Price/Sales (TTM)
4.25
vs. Analyst Target
+165.0% to analyst PT
Operating Margin (TTM)
-42.77%
Revenue (TTM)
$72.6M
Dividend Rate
None
Analyst Target Price
$12.11 (13 analysts)
Financial History
Annual Revenue & Earnings History
Year
Revenue
Net Income
Gross Profit
EBITDA
2020
$10.4M
-$51.0M
-$22.8M
-$50.7M
2021
$11.7M
-$66.8M
$11.7M
-$64.1M
2022
$14.5M
-$113M
$14.5M
-$107M
2023
$27.0M
-$181M
-$130M
-$183M
2024
$35.3M
-$169M
-$138M
-$165M
2025
$72.6M
-$219M
$72.6M
-$212M
Recent Quarterly Revenue & Net Income
Quarter
Revenue
Net Income
Jun 2025
$2.9M
-$79.0M
Sep 2025
$11.7M
-$59.1M
Dec 2025
$48.0M
-$20.2M
Mar 2026
$887,000
-$60.8M
Ownership & Float
Insider Ownership
4.4%
Institutional Ownership
73.2%
Short Float
155.3%
% of All Funds Holding
1.07%
Number of Funds Holding
88
Current Moving Averages
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
Timeframe
SMA
Value
Trend Context
Weekly
10-Week SMA
$4.76
Near-term / short-term trend
Weekly
40-Week SMA
$6.22
Medium-term trend
Weekly
80-Week SMA
$8.40
Cyclical trend (business cycle)
Weekly
200-Week SMA
$17.17
Secular trend (multi-year)
Monthly
10-Month SMA
$6.38
Near-term monthly trend
Monthly
20-Month SMA
$9.34
Medium-term monthly trend
Monthly
40-Month SMA
$15.39
Secular monthly trend
Volume Shelves — Support & Resistance
Trend Edge identifies volume shelves: price zones where historically elevated trading volume
creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative
volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
Price Level
Type
Volume Ratio
Age
$5.50
resistance
1.75x
1 months ago
$20.40
resistance
2.10x
16 months ago
$23.30
resistance
1.20x
17 months ago
Historical Earnings Reactions (29 events)
Timeframe
Avg Return
Median
Win Rate
Best
Worst
Gap
0.23%
-0.04%
44.83%
3.96%
-6.05%
1 Day
0.01%
-0.06%
48.28%
8.75%
-7.88%
1 Week
-2.69%
-3.24%
37.93%
19.04%
-38.89%
2 Weeks
-4.05%
-5.46%
24.14%
17.03%
-36.11%
1 Month
-0.54%
-4.05%
39.29%
35.71%
-31.42%
Next earnings: July 19, 2026 (51 days away)
Seasonality & Day-of-Week Patterns
Monthly Seasonality
Month
Avg Return
Win Rate
Samples
Jan
3.0%
28.6%
7
Feb
1.1%
28.6%
7
Mar
-4.7%
28.6%
7
Apr
-8.5%
42.9%
7
May
2.5%
33.3%
6
Jun
-5.1%
42.9%
7
Jul
9.4%
71.4%
7
Aug
-1.2%
42.9%
7
Sep
9.7%
71.4%
7
Oct
-0.8%
57.1%
7
Nov
0.4%
42.9%
7
Dec
-0.6%
57.1%
7
Day-of-Week Tendencies
Day
Avg Return
Win Rate
Samples
Monday
0.09%
45.9%
329
Tuesday
0.10%
47.9%
365
Wednesday
0.20%
48.6%
360
Thursday
0.12%
45.7%
352
Friday
-0.28%
47.2%
354
Top Institutional Holders
Institutional holder breakdown coming soon.
Total institutional ownership: 73.2%
Insider Transactions — Smart Summary
Total insider ownership: 4.4%
Founder-led management: Christian Heinis (Scientific Founder)
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The analysis covers five layers:
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qualitative analysis (business model, competitive moat, sector dynamics),
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