Stock analysis, trade plans, and proprietary indicators by Trend Edge.
Trend Edge Setup Score
Trend Edge rates AXSM Bullish with a Setup Score of 71, net conviction 56, actionability 90. How the Setup Score works →
Total Setup Score
71
Directional Bias
Bullish
Net Conviction
56
Actionability
90 (in range)
Key signals behind this score
40wk Uptrend — trend only (sma 202 vs px 168)
80wk Uptrend — rising+above (sma 161 vs px 168)
200wk Uptrend — rising+above (sma 113 vs px 168)
Funds Accumulating — momZ +5.56 · 4.53→5.70
Seasonal Tailwind — november med 10.3% (mag 2/3) · posClose 70.00% (rel 1/3) · n10 ×0.75 = 4.7
Founder-Led — founder/CEO led
About Axsome Therapeutics Inc
Axsome Therapeutics, Inc., a biopharmaceutical company, develops and delivers novel therapies for the management of central nervous system (CNS) disorders in the United States. The company's commercial product portfolio includes Auvelity (dextromethorphan-bupropion), a N-methyl-D-aspartate receptor antagonist, sigma-1 receptor agonist, aminoketone, and CYP2D6 inhibitor indicated for the treatment of major depressive disorder in adults; Sunosi (so… Read full Trend Edge analysis →
Sector: Healthcare
Industry: Biotechnology
Exchange: NASDAQ
IPO Date: November 19, 2015
Headquarters: One World Trade Center, New York, NY, United States, 10007
Founder-Led: Yes — Herriot Tabuteau (Founder, Chairman, CEO & President)
Key Metrics
Current Price
$168.35
Market Cap
$8.91B
Float
44.4M
Shares Outstanding
52.4M
P/E (Forward)
32.15
Price/Sales (TTM)
11.47
vs. Analyst Target
+69.0% to analyst PT
Profit Margin
-24.68%
Operating Margin (TTM)
-23.42%
Revenue (TTM)
$777M
Dividend Rate
None
Analyst Target Price
$284.54 (22 analysts)
Financial History
Annual Revenue & Earnings History
Year
Revenue
Net Income
Gross Profit
EBITDA
2020
N/A
-$103M
-$77,718
-$100M
2021
$8.8M
-$135M
-$1.2M
-$124M
2022
$50.0M
-$187M
$44.8M
-$175M
2023
$271M
-$239M
$245M
-$225M
2024
$386M
-$287M
$352M
-$273M
2025
$638M
-$183M
$591M
-$168M
Recent Quarterly Revenue & Net Income
Quarter
Revenue
Net Income
Sep 2025
$171M
-$47.2M
Dec 2025
$196M
-$28.6M
Mar 2026
$191M
-$64.5M
Jun 2026
$218M
-$51.3M
Ownership & Float
Insider Ownership
15.1%
Institutional Ownership
74.7%
Short Float
6.9%
% of All Funds Holding
5.70%
Number of Funds Holding
501
Current Moving Averages
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
Timeframe
SMA
Value
Trend Context
Weekly
10-Week SMA
$201.11
Near-term / short-term trend
Weekly
40-Week SMA
$201.54
Medium-term trend
Weekly
80-Week SMA
$161.01
Cyclical trend (business cycle)
Weekly
200-Week SMA
$113.06
Secular trend (multi-year)
Monthly
10-Month SMA
$197.34
Near-term monthly trend
Monthly
20-Month SMA
$161.26
Medium-term monthly trend
Monthly
40-Month SMA
$122.86
Secular monthly trend
Volume Shelves — Support & Resistance
Trend Edge identifies volume shelves: price zones where historically elevated trading volume
creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative
volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
Price Level
Type
Volume Ratio
Age
$242.00
resistance
1.05x
2 months ago
$150.00
support
1.02x
9 months ago
$86.00
support
1.53x
20 months ago
Historical Earnings Reactions (43 events)
Timeframe
Avg Return
Median
Win Rate
Best
Worst
Gap
-0.08%
-0.47%
37.21%
6.52%
-4.09%
1 Day
0.01%
-0.16%
48.84%
11.69%
-14.73%
1 Week
-0.94%
-1.23%
44.19%
21.38%
-23.20%
2 Weeks
0.59%
-1.11%
48.84%
44.48%
-21.56%
1 Month
4.45%
-0.24%
50.00%
106.57%
-43.29%
Next earnings: November 2, 2026 (23 days away)
Seasonality & Day-of-Week Patterns
Monthly Seasonality
Month
Avg Return
Win Rate
Samples
Jan
7.4%
36.4%
11
Feb
-3.7%
18.2%
11
Mar
5.6%
36.4%
11
Apr
15.8%
72.7%
11
May
-3.6%
36.4%
11
Jun
11.7%
63.6%
11
Jul
-3.7%
45.5%
11
Aug
4.0%
54.5%
11
Sep
-2.4%
45.5%
11
Oct
1.2%
50.0%
10
Nov
15.4%
70.0%
10
Dec
19.0%
72.7%
11
Day-of-Week Tendencies
Day
Avg Return
Win Rate
Samples
Monday
0.72%
47.6%
511
Tuesday
0.30%
50.1%
563
Wednesday
0.13%
47.3%
560
Thursday
-0.11%
46.0%
550
Friday
0.23%
49.1%
548
Top Institutional Holders
Institutional holder breakdown coming soon.
Total institutional ownership: 74.7%
Insider Transactions — Smart Summary
Total insider ownership: 15.1%
Founder-led management: Herriot Tabuteau (Founder, Chairman, CEO & President)
Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Axsome Therapeutics Inc
(AXSM) powered by Claude Opus — Anthropic's most capable AI model.
The analysis covers five layers:
technical analysis (near-term, medium-term, cyclical, and secular trend, momentum,
volume shelf support and resistance, breakout and breakdown signals),
qualitative analysis (business model, competitive moat, sector dynamics),
insider sentiment (buy and sell signals from executive and director transactions),
share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and
fundamental analysis (valuation, revenue growth, profit margin, earnings quality).
AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit,
stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward.
Whether you are building a long position, initiating a short, or looking for a reversal setup,
AI Consult identifies the highest-probability signal from the current trend.