Seasonal Tailwind — august med 2.8% (mag 1/3) · posClose 60.00% (rel 1/3) · n10 ×0.75 = 3.8
Founder-Led — founder/CEO led
About Axsome Therapeutics Inc
Axsome Therapeutics, Inc., a biopharmaceutical company, develops and delivers novel therapies for the management of central nervous system (CNS) disorders in the United States. The company's commercial product portfolio includes Auvelity (dextromethorphan-bupropion), a N-methyl-D-aspartate receptor antagonist, sigma-1 receptor agonist, aminoketone, and CYP2D6 inhibitor indicated for the treatment of major depressive disorder in adults; Sunosi (so… Read full Trend Edge analysis →
Sector: Healthcare
Industry: Biotechnology
Exchange: NASDAQ
IPO Date: November 19, 2015
Headquarters: One World Trade Center, New York, NY, United States, 10007
Founder-Led: Yes — Herriot Tabuteau (Founder, Chairman, CEO & President)
Key Metrics
Current Price
$248.95
Market Cap
$12.57B
Float
43.6M
Shares Outstanding
51.5M
P/E (Forward)
333.33
Price/Sales (TTM)
17.75
vs. Analyst Target
+11.1% to analyst PT
Profit Margin
-26.59%
Operating Margin (TTM)
-32.83%
Revenue (TTM)
$708M
Dividend Rate
None
Analyst Target Price
$276.47 (19 analysts)
Financial History
Annual Revenue & Earnings History
Year
Revenue
Net Income
Gross Profit
EBITDA
2020
N/A
-$103M
-$77,718
-$100M
2021
$8.8M
-$135M
-$1.2M
-$124M
2022
$50.0M
-$187M
$44.8M
-$175M
2023
$271M
-$239M
$245M
-$225M
2024
$386M
-$287M
$352M
-$273M
2025
$638M
-$183M
$591M
-$168M
Recent Quarterly Revenue & Net Income
Quarter
Revenue
Net Income
Jun 2025
$150M
-$48.0M
Sep 2025
$171M
-$47.2M
Dec 2025
$196M
-$28.6M
Mar 2026
$191M
-$64.5M
Ownership & Float
Insider Ownership
15.4%
Institutional Ownership
76.5%
Short Float
7.5%
% of All Funds Holding
4.68%
Number of Funds Holding
385
Current Moving Averages
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
Timeframe
SMA
Value
Trend Context
Weekly
10-Week SMA
$238.85
Near-term / short-term trend
Weekly
40-Week SMA
$181.26
Medium-term trend
Weekly
80-Week SMA
$145.70
Cyclical trend (business cycle)
Weekly
200-Week SMA
$103.20
Secular trend (multi-year)
Monthly
10-Month SMA
$192.22
Near-term monthly trend
Monthly
20-Month SMA
$151.17
Medium-term monthly trend
Monthly
40-Month SMA
$115.28
Secular monthly trend
Volume Shelves — Support & Resistance
Trend Edge identifies volume shelves: price zones where historically elevated trading volume
creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative
volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
Price Level
Type
Volume Ratio
Age
$208.00
support
1.25x
1 months ago
$172.00
support
1.14x
2 months ago
$150.00
support
1.02x
6 months ago
$86.00
support
1.53x
17 months ago
Historical Earnings Reactions (42 events)
Timeframe
Avg Return
Median
Win Rate
Best
Worst
Gap
-0.10%
-0.48%
35.71%
6.52%
-4.09%
1 Day
0.06%
0.11%
50.00%
11.69%
-14.73%
1 Week
-0.90%
-1.07%
45.24%
21.38%
-23.20%
2 Weeks
0.77%
-0.47%
50.00%
44.48%
-21.56%
1 Month
4.47%
-0.54%
48.78%
106.57%
-43.29%
Next earnings: August 3, 2026 (23 days away)
Seasonality & Day-of-Week Patterns
Monthly Seasonality
Month
Avg Return
Win Rate
Samples
Jan
7.4%
36.4%
11
Feb
-3.7%
18.2%
11
Mar
5.6%
36.4%
11
Apr
15.8%
72.7%
11
May
-3.6%
36.4%
11
Jun
11.7%
63.6%
11
Jul
-3.0%
50.0%
10
Aug
5.3%
60.0%
10
Sep
-2.0%
50.0%
10
Oct
1.2%
50.0%
10
Nov
15.4%
70.0%
10
Dec
19.0%
72.7%
11
Day-of-Week Tendencies
Day
Avg Return
Win Rate
Samples
Monday
0.77%
48.3%
499
Tuesday
0.30%
50.0%
550
Wednesday
0.13%
47.0%
547
Thursday
-0.11%
46.0%
537
Friday
0.28%
49.9%
535
Top Institutional Holders
Institutional holder breakdown coming soon.
Total institutional ownership: 76.5%
Insider Transactions — Smart Summary
Total insider ownership: 15.4%
Founder-led management: Herriot Tabuteau (Founder, Chairman, CEO & President)
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