APVO — Aptevo Therapeutics Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

About Aptevo Therapeutics Inc

Aptevo Therapeutics Inc., a clinical-stage research and development biotechnology company, focuses on developing immunotherapeutic candidates for the treatment of various forms of cancer in the United States. The company develops its products using ADAPTIR and ADAPTIR-FLEX platforms to generate monospecific, bispecific, and multi-specific antibody candidates capable of enhancing the human immune system against cancer cells. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$4.97
Market Cap$5.7M
Float1.2M
Shares Outstanding1.2M
P/E (Forward)3.89
Price/Sales (TTM)2.70
vs. Analyst Target+322.5% to analyst PT
Dividend RateNone
Analyst Target Price$21.00 (1 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $4.3M -$17.8M -$13.5M -$26.2M
2021 $12.3M -$27.3M $12.3M -$20.3M
2022 $3.1M $8.0M $3.1M -$27.7M
2023 N/A -$17.4M -$567,000 -$28.3M
2024 N/A -$24.1M -$352,000 -$23.8M
2025 N/A -$26.0M -$240,000 -$26.1M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Mar 2025 N/A -$6.4M
Jun 2025 N/A -$6.2M
Sep 2025 N/A -$7.5M
Dec 2025 -$220,000 -$5.8M

Ownership & Float

Insider Ownership0.1%
Institutional Ownership2.2%
Short Float8.8%
% of All Funds Holding0.13%
Number of Funds Holding10

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$4.83Near-term / short-term trend
Weekly40-Week SMA$17.15Medium-term trend
Weekly80-Week SMA$573.22Cyclical trend (business cycle)
Weekly200-Week SMA$423721.97Secular trend (multi-year)
Monthly10-Month SMA$14.65Near-term monthly trend
Monthly20-Month SMA$638.73Medium-term monthly trend
Monthly40-Month SMA$176939.57Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$86.00 resistance 8.83x 10 months ago
$185.00 resistance 4.27x 11 months ago
$399.00 resistance 8.32x 12 months ago
$3720.00 resistance 3.02x 16 months ago
$4840.00 resistance 1.03x 19 months ago

Historical Earnings Reactions (39 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.04% 0.62% 58.97% 8.52% -11.29%
1 Day 0.76% 0.00% 41.03% 32.82% -13.55%
1 Week -4.10% -4.82% 33.33% 36.24% -42.75%
2 Weeks -4.47% -3.42% 33.33% 26.62% -35.26%
1 Month -7.55% -6.21% 34.21% 37.83% -48.71%

Next earnings: May 21, 2026 (10 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan-8.9%20.0%10
Feb-5.7%30.0%10
Mar-23.1%30.0%10
Apr-12.3%30.0%10
May-2.7%55.6%9
Jun-8.7%22.2%9
Jul-4.2%44.4%9
Aug-17.6%10.0%10
Sep-7.5%10.0%10
Oct-0.3%30.0%10
Nov48.1%50.0%10
Dec-16.1%30.0%10

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.97% 39.8% 460
Tuesday 0.02% 42.9% 506
Wednesday 0.15% 45.5% 503
Thursday -0.38% 41.8% 495
Friday -0.70% 40.9% 496

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 2.2%

Insider Transactions — Smart Summary

Total insider ownership: 0.1%

12-Month Insider Activity Summary

Total Filings1
Net Value+N/A
Net Shares Change13,513
% of Float1.1%
C-Suite Filings0
Clusters Detected0

Key Insiders

NameTitleNet ValueFilingsActivity
Grant Grady III +$20,134.37 1 1 buy

Significant Filings

DateInsiderTitleNet ValuePrice After
2025-11-12 Grant Grady III +$20,134.37 Transaction at $1.49, now +233.6%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Aptevo Therapeutics Inc (APVO) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for APVO on Trend Edge →