APVO — Aptevo Therapeutics Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates APVO Bearish with a Setup Score of 45, net conviction 49, actionability 42. How the Setup Score works →

Total Setup Score45
Directional BiasBearish
Net Conviction49
Actionability42 (in range)

Key signals behind this score

About Aptevo Therapeutics Inc

Aptevo Therapeutics Inc., a clinical-stage research and development biotechnology company, focuses on developing immunotherapeutic candidates for the treatment of various forms of cancer in the United States. The company develops its products using ADAPTIR and ADAPTIR-FLEX platforms to generate monospecific, bispecific, and multi-specific antibody candidates capable of enhancing the human immune system against cancer cells. Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$2.68
Market Cap$5.0M
Float1.1M
Shares Outstanding1.8M
P/E (Forward)3.89
P/E (TTM)0.01
Price/Sales (TTM)2.70
vs. Analyst Target+851.5% to analyst PT
Dividend RateNone
Analyst Target Price$25.50 (1 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $4.3M -$17.8M -$13.5M -$26.2M
2021 $12.3M -$27.3M $12.3M -$20.3M
2022 $3.1M $8.0M $3.1M $7.9M
2023 N/A -$17.4M -$567,000 -$18.1M
2024 N/A -$24.1M -$352,000 -$23.8M
2025 N/A -$26.0M -$240,000 -$25.7M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 N/A -$7.5M
Dec 2025 -$220,000 -$5.8M
Mar 2026 N/A -$6.7M
Jun 2026 N/A -$6.4M

Ownership & Float

Insider Ownership6.8%
Institutional Ownership3.4%
Short Float7.7%
% of All Funds Holding0.10%
Number of Funds Holding9

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$4.07Near-term / short-term trend
Weekly40-Week SMA$7.63Medium-term trend
Weekly80-Week SMA$128.85Cyclical trend (business cycle)
Weekly200-Week SMA$267253.59Secular trend (multi-year)
Monthly10-Month SMA$7.41Near-term monthly trend
Monthly20-Month SMA$195.41Medium-term monthly trend
Monthly40-Month SMA$87928.95Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$86.00 resistance 8.83x 13 months ago
$185.00 resistance 4.27x 14 months ago
$399.00 resistance 8.32x 15 months ago
$3720.00 resistance 3.02x 19 months ago
$4840.00 resistance 1.03x 22 months ago

Historical Earnings Reactions (41 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.05% 0.49% 56.10% 9.58% -11.29%
1 Day -2.16% -0.66% 39.02% 12.76% -16.49%
1 Week -7.42% -7.76% 27.50% 20.00% -44.33%
2 Weeks -7.39% -6.59% 25.00% 18.67% -44.44%
1 Month -8.63% -9.30% 35.00% 37.83% -61.44%

Next earnings: November 2, 2026 (69 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan-8.9%20.0%10
Feb-5.7%30.0%10
Mar-23.1%30.0%10
Apr-12.3%30.0%10
May-2.3%60.0%10
Jun-8.8%20.0%10
Jul-4.5%40.0%10
Aug-17.6%10.0%10
Sep-7.5%10.0%10
Oct-0.3%30.0%10
Nov48.1%50.0%10
Dec-16.1%30.0%10

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.95% 39.7% 474
Tuesday -0.00% 42.4% 521
Wednesday 0.11% 45.4% 518
Thursday -0.38% 42.0% 510
Friday -0.72% 40.7% 509

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 3.4%

Insider Transactions — Smart Summary

Total insider ownership: 6.8%

12-Month Insider Activity Summary

Total Filings1
Net Value+N/A
Net Shares Change13,513
% of Float1.2%
C-Suite Filings0
Clusters Detected0

Key Insiders

NameTitleNet ValueFilingsActivity
Grant Grady III +$20,134.37 1 1 buy

Significant Filings

DateInsiderTitleNet ValuePrice After
2025-11-12 Grant Grady III +$20,134.37 Transaction at $1.49, now +79.9%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Aptevo Therapeutics Inc (APVO) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for APVO on Trend Edge →