Stock analysis, trade plans, and proprietary indicators by Trend Edge.
Trend Edge rates ANVS Bearish with a Setup Score of 25, net conviction 26, actionability 24. How the Setup Score works →
| Total Setup Score | 25 |
|---|---|
| Directional Bias | Bearish |
| Net Conviction | 26 |
| Actionability | 24 (in range) |
Annovis Bio, Inc., a clinical stage drug platform company, develops drugs to treat neurodegeneration in the United States. The company's lead product candidate is Buntanetap, which is in phase 3 to treat alzheimer's disease, as well as in open-label phase 3 to treat parkinson's disease. It also develops ANVS405, which is in phase 2 and 3 clinical trials for the treatment of traumatic brain injury and/or stroke; and ANVS301, which finished phase 1… Read full Trend Edge analysis →
| Current Price | $1.86 |
|---|---|
| Market Cap | $84.7M |
| Float | 30.7M |
| Shares Outstanding | 42.5M |
| vs. Analyst Target | +572.0% to analyst PT |
| Dividend Rate | None |
| Analyst Target Price | $12.50 (4 analysts) |
| Year | Revenue | Net Income | Gross Profit | EBITDA |
|---|---|---|---|---|
| 2020 | N/A | -$5.5M | N/A | -$5.5M |
| 2021 | N/A | -$14.5M | N/A | -$14.5M |
| 2022 | N/A | -$25.1M | N/A | -$25.5M |
| 2023 | N/A | -$56.2M | N/A | -$56.2M |
| 2024 | N/A | -$24.6M | N/A | -$22.7M |
| 2025 | N/A | -$28.9M | N/A | -$28.9M |
| Quarter | Revenue | Net Income |
|---|---|---|
| Jun 2025 | N/A | -$6.2M |
| Sep 2025 | N/A | -$7.3M |
| Dec 2025 | N/A | -$9.8M |
| Mar 2026 | N/A | -$17.6M |
| Insider Ownership | 8.3% |
|---|---|
| Institutional Ownership | 16.7% |
| Short Float | 15.7% |
| % of All Funds Holding | 0.64% |
| Number of Funds Holding | 53 |
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
| Timeframe | SMA | Value | Trend Context |
|---|---|---|---|
| Weekly | 10-Week SMA | $1.94 | Near-term / short-term trend |
| Weekly | 40-Week SMA | $2.54 | Medium-term trend |
| Weekly | 80-Week SMA | $2.53 | Cyclical trend (business cycle) |
| Weekly | 200-Week SMA | $7.73 | Secular trend (multi-year) |
| Monthly | 10-Month SMA | $2.59 | Near-term monthly trend |
| Monthly | 20-Month SMA | $2.61 | Medium-term monthly trend |
| Monthly | 40-Month SMA | $6.37 | Secular monthly trend |
Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
| Price Level | Type | Volume Ratio | Age |
|---|---|---|---|
| $1.50 | support | 1.19x | 13 months ago |
| Timeframe | Avg Return | Median | Win Rate | Best | Worst |
|---|---|---|---|---|---|
| Gap | -1.67% | 0.52% | 57.69% | 16.47% | -45.48% |
| 1 Day | -2.77% | -1.47% | 26.92% | 22.04% | -60.25% |
| 1 Week | -1.32% | -1.03% | 42.31% | 65.50% | -61.17% |
| 2 Weeks | 0.17% | -6.72% | 34.62% | 96.94% | -61.79% |
| 1 Month | 8.60% | -5.54% | 44.00% | 233.39% | -67.10% |
Next earnings: August 11, 2026 (31 days away)
Insufficient historical data for monthly seasonality analysis (requires 7+ years of data).
| Day | Avg Return | Win Rate | Samples |
|---|---|---|---|
| Monday | 0.54% | 46.4% | 302 |
| Tuesday | 0.30% | 45.5% | 334 |
| Wednesday | 0.17% | 47.9% | 332 |
| Thursday | -0.18% | 47.1% | 325 |
| Friday | 0.26% | 47.8% | 322 |
Institutional holder breakdown coming soon.
Total institutional ownership: 16.7%
Total insider ownership: 8.3%
Founder-led management: Maria L. Maccecchini (Founder, CEO, President & Executive Director)
| Total Filings | 8 |
|---|---|
| Net Value | +$200,000.05 |
| Net Shares Change | 1,982,515 |
| % of Float | 6.5% |
| C-Suite Filings | 1 |
| Clusters Detected | 0 |
| Name | Title | Net Value | Filings | Activity |
|---|---|---|---|---|
| Hoffman Michael B | +$4.1M | 7 | 7 buy | |
| Maccecchini Maria-Luisa | President & CEO | +$200,000.05 | 1 | 1 buy |
| Date | Insider | Title | Net Value | Price After |
|---|---|---|---|---|
| 2026-05-21 | Hoffman Michael B | +$142,778.549 | Transaction at $1.87, now -0.5% | |
| 2026-04-03 | Hoffman Michael B | +$1.5M | Transaction at $2.10, now -11.4% | |
| 2025-11-12 | Maccecchini Maria-Luisa | President & CEO | +$200,000.05 | Transaction at $2.05, now -9.3% |
| 2025-11-12 | Hoffman Michael B | +$2.0M | Transaction at $2.05, now -9.3% | |
| 2025-12-08 | Hoffman Michael B | +$193,792.5 | Transaction at $4.31, now -56.8% | |
| 2025-11-25 | Hoffman Michael B | +$159,885.04 | Transaction at $4.08, now -54.4% |
Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Annovis Bio Inc (ANVS) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).
AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.
Get the full AI Consult analysis for ANVS on Trend Edge →