ANNX — Annexon Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates ANNX Bearish with a Setup Score of 43, net conviction 26, actionability 72. How the Setup Score works →

Total Setup Score43
Directional BiasBearish
Net Conviction26
Actionability72 (in range)

Key signals behind this score

About Annexon Inc

Annexon, Inc., a clinical-stage biopharmaceutical company, discovers and develops medicines for treating inflammatory-related diseases. The company provides Tanruprubart, an investigational full-length monoclonal antibody, which is in Phase 3 clinical trial for the treatment of patients with guillain-barré syndrome; completed Phase II clinical trial for treating Huntington's disease; and in Phase 2a clinical trial for the treatment of amyotrophic… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$4.02
Market Cap$758M
Float163.8M
Shares Outstanding189.6M
vs. Analyst Target+283.8% to analyst PT
Dividend RateNone
Analyst Target Price$15.43 (10 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 N/A -$62.7M -$667,000 -$62.8M
2021 N/A -$128M -$3.4M -$129M
2022 N/A -$138M -$3.3M -$143M
2023 N/A -$134M -$3.3M -$132M
2024 N/A -$138M -$3.5M -$135M
2025 N/A -$207M -$3.7M -$204M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 N/A -$54.9M
Dec 2025 N/A -$48.3M
Mar 2026 N/A -$44.1M
Jun 2026 N/A -$55.3M

Ownership & Float

Insider Ownership0.4%
Institutional Ownership103.1%
Short Float19.6%
% of All Funds Holding2.44%
Number of Funds Holding215

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$4.56Near-term / short-term trend
Weekly40-Week SMA$5.27Medium-term trend
Weekly80-Week SMA$4.06Cyclical trend (business cycle)
Weekly200-Week SMA$4.39Secular trend (multi-year)
Monthly10-Month SMA$5.27Near-term monthly trend
Monthly20-Month SMA$4.05Medium-term monthly trend
Monthly40-Month SMA$4.31Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$4.90 resistance 1.13x 0 months ago
$3.20 support 1.60x 10 months ago
$2.10 support 1.49x 12 months ago

Historical Earnings Reactions (25 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 1.61% 1.46% 68.00% 13.71% -2.05%
1 Day 2.93% 1.46% 56.00% 23.08% -5.60%
1 Week 3.04% 0.85% 52.00% 31.92% -18.80%
2 Weeks 1.13% -2.10% 44.00% 48.99% -20.19%
1 Month 3.20% 11.18% 58.33% 66.78% -46.48%

Next earnings: November 9, 2026 (29 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

Insufficient historical data for monthly seasonality analysis (requires 7+ years of data).

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.08% 45.0% 291
Tuesday 0.15% 44.7% 322
Wednesday 0.31% 51.6% 320
Thursday -0.43% 45.5% 312
Friday 0.34% 46.6% 311

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 103.1%

Insider Transactions — Smart Summary

Total insider ownership: 0.4%

12-Month Insider Activity Summary

Total Filings21
Net Value-$213,598.85
Net Shares Change2,971,823
% of Float1.8%
C-Suite Filings11
Clusters Detected2

Key Insiders

NameTitleNet ValueFilingsActivity
Satter Muneer A +$12.0M 3 3 buy
Choi Jung +$138,270 1 1 buy
Love Douglas PRESIDENT AND CEO +$99,828.95 1 1 buy
Yednock Ted EVP & CHIEF INNOVATION OFFICER -$70,316.99 2 2 sell
Lew Jennifer EVP & CHIEF FINANCIAL OFFICER -$40,118.61 1 1 sell
Dananberg Jamie CHIEF MEDICAL OFFICER -$26,979 1 1 sell
Overdorf Michael EVP & CHIEF BUSINESS OFFICER -$23,517.38 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-11-19 – 2025-12-03 4 3 +$8.8M
2026-02-20 – 2026-03-04 10 5 -$313,427.8 10 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-09-25 Love Douglas PRESIDENT AND CEO +$99,828.95 Transaction at $3.83, now +5.0%
2026-05-29 Satter Muneer A +$3.3M Transaction at $5.41, now -25.7%
2025-11-19 Satter Muneer A +$5.1M Transaction at $3.37, now +19.3%
2025-12-03 Choi Jung +$138,270 Transaction at $4.19, now -4.1%
2025-11-21 Satter Muneer A +$3.6M Transaction at $4.38, now -8.2%
2026-02-20 Yednock Ted EVP & CHIEF INNOVATION OFFICER -$40,149.27 Transaction at $5.11, now -21.3%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Annexon Inc (ANNX) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for ANNX on Trend Edge →