ANAB — AnaptysBio Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates ANAB Bullish with a Setup Score of 0, net conviction 51, actionability 0. How the Setup Score works →

Total Setup Score0
Directional BiasBullish
Net Conviction51
Actionability0 (in range)

Key signals behind this score

About AnaptysBio Inc

AnaptysBio, Inc., a clinical-stage biotechnology company, focuses in delivering immunology therapeutics for autoimmune and inflammatory diseases in the United States. The company's products include Rosnilimab, a selective pathogenic T cell deplete which completed a Phase 2b trial for the treatment of moderate-to-severe rheumatoid arthritis; ANB033, a CD122 antagonist, which is in a Phase 1b trial for celiac disease and eosinophilic esophagitis; A… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$66.39
Market Cap$1.97B
Float19.8M
Shares Outstanding29.6M
Price/Sales (TTM)8.48
vs. Analyst Target+31.2% to analyst PT
Profit Margin-11.53%
Operating Margin (TTM)-135.53%
Revenue (TTM)$232M
Dividend RateNone
Analyst Target Price$87.09 (12 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $75.0M -$19.9M -$5.0M -$19.4M
2021 $63.2M -$57.8M -$35.3M -$55.7M
2022 $10.3M -$129M -$78.5M -$105M
2023 $17.2M -$164M -$115M -$156M
2024 $91.3M -$145M -$72.6M -$92.7M
2025 $235M -$13.2M $232M $69.2M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $22.3M -$38.6M
Sep 2025 $76.3M $15.1M
Dec 2025 $108M $49.6M
Mar 2026 $25.6M -$52.9M

Ownership & Float

Insider Ownership5.7%
Institutional Ownership102.4%
Short Float23.4%
% of All Funds Holding2.21%
Number of Funds Holding182

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$60.48Near-term / short-term trend
Weekly40-Week SMA$40.90Medium-term trend
Weekly80-Week SMA$27.31Cyclical trend (business cycle)
Weekly200-Week SMA$20.46Secular trend (multi-year)
Monthly10-Month SMA$44.51Near-term monthly trend
Monthly20-Month SMA$29.21Medium-term monthly trend
Monthly40-Month SMA$22.40Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$12.40 support 1.17x 14 months ago
$9.00 support 1.47x 17 months ago

Historical Earnings Reactions (38 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 1.71% 0.21% 52.63% 18.60% -7.01%
1 Day -0.85% 0.14% 50.00% 11.72% -23.10%
1 Week -1.64% -0.52% 47.37% 15.60% -15.38%
2 Weeks -1.52% -1.59% 44.74% 27.31% -23.20%
1 Month 3.25% -0.10% 48.65% 58.94% -28.12%

Next earnings: August 5, 2026 (22 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan3.8%55.6%9
Feb8.9%80.0%10
Mar-5.5%40.0%10
Apr10.0%50.0%10
May-4.1%40.0%10
Jun2.7%60.0%10
Jul2.9%55.6%9
Aug1.6%55.6%9
Sep6.0%55.6%9
Oct20.1%66.7%9
Nov-4.4%33.3%9
Dec5.5%66.7%9

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.02% 48.8% 445
Tuesday 0.25% 48.8% 488
Wednesday 0.38% 53.4% 485
Thursday 0.13% 49.3% 477
Friday 0.15% 50.8% 476

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 102.4%

Insider Transactions — Smart Summary

Total insider ownership: 5.7%

12-Month Insider Activity Summary

Total Filings24
Net Value-$6.6M
Net Shares Change55,003
% of Float0.3%
C-Suite Filings20
Clusters Detected2

Key Insiders

NameTitleNet ValueFilingsActivity
Schmid John P. -$1.2M 1 1 sell
LOUMEAU ERIC J CHIEF LEGAL OFFICER -$538,009.171 2 N/A
MULROY DENNIS CHIEF FINANCIAL OFFICER -$343,998.91 3 N/A
Lizzul Paul F. Chief Medical Officer -$264,012.35 2 N/A
Marquet Magda -$243,321.1 1 1 sell
Ware J. Anthony -$193,342.5 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-12-18 – 2025-12-23 6 4 -$2.1M 5 C-suite
2026-01-06 – 2026-01-16 13 5 -$3.4M 12 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-04-01 Schmid John P. -$1.2M Transaction at $56.11, now +18.3%
2026-01-16 Marquet Magda -$243,321.1 Transaction at $37.17, now +78.6%
2025-12-23 Ware J. Anthony -$193,342.5 Transaction at $49.58, now +33.9%
2026-01-09 MULROY DENNIS CHIEF FINANCIAL OFFICER -$112,445.65 Transaction at $44.71, now +48.5%
2026-01-09 Lizzul Paul F. Chief Medical Officer -$163,191.5 Transaction at $44.71, now +48.5%
2026-01-09 LOUMEAU ERIC J CHIEF LEGAL OFFICER -$98,809.1 Transaction at $44.71, now +48.5%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for AnaptysBio Inc (ANAB) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for ANAB on Trend Edge →