ALNY — Alnylam Pharmaceuticals Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates ALNY Bullish with a Setup Score of 28, net conviction 28, actionability 28. How the Setup Score works →

Total Setup Score28
Directional BiasBullish
Net Conviction28
Actionability28 (in range)

Key signals behind this score

About Alnylam Pharmaceuticals Inc

Alnylam Pharmaceuticals, Inc. discovers, develops, manufactures, and commercializes therapeutics based on ribonucleic acid interference in the United States, Europe, and internationally. The company offers ONPATTRO for hereditary transthyretin-mediated (hATTR) amyloidosis; AMVUTTRA for ATTR and hATTR amyloidosis; Leqvio for hypercholesterolemia; Qfitlia for hemophilia A or B; GIVLAARI for acute hepatic porphyria; and OXLUMO for primary hyperoxalu… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$298.76
Market Cap$41.76B
Float132.9M
Shares Outstanding133.5M
P/E (Forward)36.76
P/E (TTM)81.24
Price/Sales (TTM)9.74
vs. Analyst Target+46.9% to analyst PT
Profit Margin12.55%
Operating Margin (TTM)23.02%
Revenue (TTM)$4.29B
Dividend RateNone
Analyst Target Price$438.75 (30 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $493M -$858M $415M -$736M
2021 $844M -$853M $704M -$662M
2022 $1.04B -$1.13B $869M -$927M
2023 $1.83B -$440M $1.52B -$258M
2024 $2.25B -$278M $1.92B -$179M
2025 $3.71B $314M $3.04B $631M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $774M -$66.3M
Sep 2025 $1.25B $251M
Dec 2025 $1.10B $186M
Mar 2026 $1.17B $206M

Ownership & Float

Insider Ownership0.2%
Institutional Ownership102.0%
Short Float4.1%
% of All Funds Holding9.00%
Number of Funds Holding740

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$294.84Near-term / short-term trend
Weekly40-Week SMA$355.68Medium-term trend
Weekly80-Week SMA$336.45Cyclical trend (business cycle)
Weekly200-Week SMA$256.85Secular trend (multi-year)
Monthly10-Month SMA$351.80Near-term monthly trend
Monthly20-Month SMA$336.50Medium-term monthly trend
Monthly40-Month SMA$267.24Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$399.00 resistance 1.22x 5 months ago
$450.00 resistance 1.53x 6 months ago
$258.00 support 1.28x 13 months ago
$247.00 support 1.01x 15 months ago
$150.00 support 2.02x 24 months ago

Historical Earnings Reactions (88 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.12% 0.00% 47.73% 12.65% -8.23%
1 Day -0.20% -0.52% 40.91% 15.20% -12.63%
1 Week 1.36% -0.09% 47.73% 52.30% -23.94%
2 Weeks 1.39% -0.63% 46.59% 62.94% -30.74%
1 Month 3.38% 2.05% 54.02% 46.30% -27.66%

Next earnings: July 30, 2026 (18 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan2.9%50.0%22
Feb0.3%45.5%22
Mar-1.3%45.5%22
Apr-2.2%36.4%22
May3.8%59.1%22
Jun5.3%59.1%22
Jul10.7%68.2%22
Aug3.7%59.1%22
Sep3.5%54.5%22
Oct-4.2%40.9%22
Nov7.8%72.7%22
Dec0.6%45.5%22

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.23% 50.6% 1041
Tuesday 0.07% 50.5% 1141
Wednesday 0.27% 52.2% 1142
Thursday -0.03% 49.1% 1120
Friday 0.12% 50.7% 1113

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 102.0%

Insider Transactions — Smart Summary

Total insider ownership: 0.2%

12-Month Insider Activity Summary

Total Filings39
Net Value-$56.9M
Net Shares Change47,725
% of Float0.0%
C-Suite Filings35
Clusters Detected5

Key Insiders

NameTitleNet ValueFilingsActivity
Greenstreet Yvonne Chief Executive Officer -$7.9M 3 3 sell
Tanguler Tolga EVP, Chief Commercial Officer -$2.4M 4 4 sell
Garg Pushkal EVP Chief R&D -$1.2M 2 2 sell
Poulton Jeffrey V. EVP, Chief Financial Officer -$1.0M 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-08-15 – 2025-08-19 7 7 -$20.6M 5 C-suite
2025-10-03 – 2025-10-03 5 5 -$10.2M 5 C-suite
2026-01-14 – 2026-01-14 5 5 -$7.0M 5 C-suite
2026-02-17 – 2026-03-02 6 5 -$7.0M 6 C-suite
2026-03-04 – 2026-03-06 10 5 -$10.1M 10 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-01-14 Greenstreet Yvonne Chief Executive Officer -$3.5M Transaction at $362.86, now -17.7%
2026-02-17 Garg Pushkal EVP Chief R&D -$695,201.154 Transaction at $310.08, now -3.7%
2026-01-14 Garg Pushkal EVP Chief R&D -$547,929.019 Transaction at $362.87, now -17.7%
2026-03-04 Greenstreet Yvonne Chief Executive Officer -$2.2M Transaction at $327.65, now -8.8%
2026-02-17 Greenstreet Yvonne Chief Executive Officer -$2.2M Transaction at $310.08, now -3.7%
2026-01-14 Poulton Jeffrey V. EVP, Chief Financial Officer -$1.0M Transaction at $362.87, now -17.7%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Alnylam Pharmaceuticals Inc (ALNY) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for ALNY on Trend Edge →