AGIO — Agios Pharm

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates AGIO Bullish with a Setup Score of 43, net conviction 25, actionability 75. How the Setup Score works →

Total Setup Score43
Directional BiasBullish
Net Conviction25
Actionability75 (in range)

Key signals behind this score

About Agios Pharm

Agios Pharmaceuticals, Inc., a biopharmaceutical company, discovers and develops medicines in the field of cellular metabolism in the United States. Its lead product includes PYRUKYND (mitapivat), an activator of wild-type and mutant pyruvate kinase (PK), enzymes used for the treatment of hemolytic anemias in adults with PK deficiency. The company's PYRUKYND product is also used for the treatment of sickle cell disease that is in phase 3 clinical… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$31.81
Market Cap$1.91B
Float50.0M
Shares Outstanding59.7M
P/E (Forward)2.47
Price/Sales (TTM)19.38
vs. Analyst Target+44.6% to analyst PT
Operating Margin (TTM)-247.07%
Revenue (TTM)$98.3M
Dividend RateNone
Analyst Target Price$46.00 (10 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $203M -$327M -$18.8M -$311M
2021 $41,409 $1.60B -$18.8M -$338M
2022 $14.2M -$232M $12.5M -$223M
2023 $26.8M -$352M $17.3M -$345M
2024 $36.5M $674M $32.3M $724M
2025 $54.0M -$413M $42.5M -$409M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 $12.9M -$103M
Dec 2025 $20.0M -$108M
Mar 2026 $20.7M -$99.1M
Jun 2026 $44.7M -$101M

Ownership & Float

Insider Ownership1.1%
Institutional Ownership112.3%
Short Float15.1%
% of All Funds Holding2.69%
Number of Funds Holding237

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$32.82Near-term / short-term trend
Weekly40-Week SMA$31.28Medium-term trend
Weekly80-Week SMA$32.73Cyclical trend (business cycle)
Weekly200-Week SMA$32.31Secular trend (multi-year)
Monthly10-Month SMA$31.48Near-term monthly trend
Monthly20-Month SMA$32.69Medium-term monthly trend
Monthly40-Month SMA$33.44Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$37.40 resistance 1.05x 2 months ago
$28.20 support 1.03x 3 months ago
$42.00 resistance 2.60x 10 months ago
$59.00 resistance 1.66x 21 months ago

Historical Earnings Reactions (53 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap 0.00% 0.07% 56.60% 3.22% -5.30%
1 Day 1.04% 0.04% 50.94% 13.82% -10.04%
1 Week 2.44% -0.26% 49.06% 34.83% -15.67%
2 Weeks 2.43% 1.09% 50.94% 34.25% -22.02%
1 Month 5.55% 5.41% 65.38% 65.42% -36.34%

Next earnings: October 29, 2026 (18 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan4.0%84.6%13
Feb6.1%69.2%13
Mar-0.2%53.8%13
Apr-0.7%53.8%13
May5.2%61.5%13
Jun6.2%69.2%13
Jul-2.6%38.5%13
Aug-3.0%42.9%14
Sep3.9%50.0%14
Oct-0.7%38.5%13
Nov3.3%61.5%13
Dec-5.1%38.5%13

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.01% 50.4% 623
Tuesday 0.08% 52.0% 684
Wednesday 0.25% 51.0% 679
Thursday 0.09% 50.1% 668
Friday -0.03% 48.9% 665

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 112.3%

Insider Transactions — Smart Summary

Total insider ownership: 1.1%

12-Month Insider Activity Summary

Total Filings26
Net Value-$4.6M
Net Shares Change125,593
% of Float0.3%
C-Suite Filings25
Clusters Detected3

Key Insiders

NameTitleNet ValueFilingsActivity
Gheuens Sarah Chief Medical Officer -$914,400 1 N/A
Goff Brian Chief Executive Officer -$661,850.28 1 N/A
Washburn Theodore James Jr. Principal Accounting Officer -$216,633.44 2 1 sell
Milanova Tsveta Chief Commercial Officer -$196,281.3 2 N/A
Viswanadhan Krishnan Chief Corp Dev & Strategy -$184,967.09 2 N/A
Burns James William Chief Legal Officer -$113,848.8 1 N/A
Jones Cecilia Chief Financial Officer -$109,024.11 1 N/A

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-01-02 – 2026-01-07 6 5 -$901,977.23 6 C-suite
2026-03-03 – 2026-03-09 8 7 -$1.3M 8 C-suite
2026-04-06 – 2026-04-06 6 6 -$1.2M 6 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-08-06 Gheuens Sarah Chief Medical Officer -$914,400 Transaction at $30.48, now +4.4%
2026-03-05 Washburn Theodore James Jr. Principal Accounting Officer -$152,255.36 Transaction at $28.88, now +10.1%
2026-04-06 Viswanadhan Krishnan Chief Corp Dev & Strategy -$102,706.89 Transaction at $34.71, now -8.4%
2026-04-06 Milanova Tsveta Chief Commercial Officer -$113,224.02 Transaction at $34.71, now -8.4%
2026-04-06 Jones Cecilia Chief Financial Officer -$109,024.11 Transaction at $34.71, now -8.4%
2026-04-06 Goff Brian Chief Executive Officer -$661,850.28 Transaction at $34.71, now -8.4%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Agios Pharm (AGIO) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for AGIO on Trend Edge →