AGIO — Agios Pharm

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

About Agios Pharm

Agios Pharmaceuticals, Inc., a biopharmaceutical company, discovers and develops medicines in the field of cellular metabolism in the United States. Its lead product includes PYRUKYND (mitapivat), an activator of wild-type and mutant pyruvate kinase (PK), enzymes used for the treatment of hemolytic anemias in adults with PK deficiency. The company's PYRUKYND product is also used for the treatment of sickle cell disease that is in phase 3 clinical… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$28.62
Market Cap$1.71B
Float53.1M
Shares Outstanding59.5M
P/E (Forward)2.47
Price/Sales (TTM)25.92
vs. Analyst Target+43.7% to analyst PT
Operating Margin (TTM)-530.34%
Revenue (TTM)$66.0M
Dividend RateNone
Analyst Target Price$41.13 (9 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $203M -$327M -$18.8M -$311M
2021 $41,409 $1.60B -$18.8M -$338M
2022 $14.2M -$232M $12.5M -$380M
2023 $26.8M -$352M $17.3M -$385M
2024 $36.5M $674M $32.3M -$420M
2025 $54.0M -$413M $42.5M -$467M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $12.5M -$112M
Sep 2025 $12.9M -$103M
Dec 2025 $20.0M -$108M
Mar 2026 $20.7M -$99.1M

Ownership & Float

Insider Ownership1.1%
Institutional Ownership108.6%
Short Float13.1%
% of All Funds Holding2.58%
Number of Funds Holding212

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$29.89Near-term / short-term trend
Weekly40-Week SMA$31.95Medium-term trend
Weekly80-Week SMA$33.61Cyclical trend (business cycle)
Weekly200-Week SMA$31.82Secular trend (multi-year)
Monthly10-Month SMA$32.56Near-term monthly trend
Monthly20-Month SMA$34.69Medium-term monthly trend
Monthly40-Month SMA$32.39Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$33.80 resistance 1.25x 0 months ago
$42.00 resistance 2.60x 5 months ago
$59.00 resistance 1.66x 16 months ago

Historical Earnings Reactions (52 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.04% 0.05% 55.77% 3.22% -5.30%
1 Day 1.22% 0.09% 51.92% 13.82% -10.04%
1 Week 2.52% -0.12% 50.00% 34.83% -15.67%
2 Weeks 2.43% 0.27% 50.00% 34.25% -22.02%
1 Month 5.77% 5.96% 66.67% 65.42% -36.34%

Next earnings: July 18, 2026 (50 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan4.0%84.6%13
Feb6.1%69.2%13
Mar-0.2%53.8%13
Apr-0.7%53.8%13
May5.2%58.3%12
Jun4.6%66.7%12
Jul-1.2%41.7%12
Aug-4.1%38.5%13
Sep4.3%53.8%13
Oct-0.7%38.5%13
Nov3.3%61.5%13
Dec-5.1%38.5%13

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday -0.00% 50.1% 605
Tuesday 0.05% 51.8% 666
Wednesday 0.24% 50.8% 660
Thursday 0.10% 50.2% 649
Friday -0.01% 49.2% 648

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 108.6%

Insider Transactions — Smart Summary

Total insider ownership: 1.1%

12-Month Insider Activity Summary

Total Filings38
Net Value-$5.7M
Net Shares Change195,708
% of Float0.4%
C-Suite Filings33
Clusters Detected4

Key Insiders

NameTitleNet ValueFilingsActivity
Goff Brian Chief Executive Officer -$661,850.28 1 N/A
Jones Cecilia Chief Financial Officer -$254,837.71 2 N/A
Washburn Theodore James Jr. Principal Accounting Officer -$216,633.44 2 1 sell
Milanova Tsveta Chief Commercial Officer -$196,281.3 2 N/A
Viswanadhan Krishnan Chief Corp Dev and Strategy -$184,967.09 2 N/A
Burns James William Chief Legal Officer -$113,848.8 1 N/A

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2025-06-26 – 2025-07-03 6 5 -$1.1M 6 C-suite
2026-01-02 – 2026-01-07 6 5 -$901,977.23 6 C-suite
2026-03-03 – 2026-03-09 8 7 -$1.3M 8 C-suite
2026-04-06 – 2026-04-06 6 6 -$1.2M 6 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-03-05 Washburn Theodore James Jr. Principal Accounting Officer -$152,255.36 Transaction at $28.88, now -0.9%
2026-04-06 Viswanadhan Krishnan Chief Corp Dev and Strategy -$102,706.89 Transaction at $34.71, now -17.5%
2026-04-06 Milanova Tsveta Chief Commercial Officer -$113,224.02 Transaction at $34.71, now -17.5%
2026-04-06 Jones Cecilia Chief Financial Officer -$109,024.11 Transaction at $34.71, now -17.5%
2026-04-06 Goff Brian Chief Executive Officer -$661,850.28 Transaction at $34.71, now -17.5%
2026-04-06 Burns James William Chief Legal Officer -$113,848.8 Transaction at $34.71, now -17.5%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Agios Pharm (AGIO) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for AGIO on Trend Edge →