Stock analysis, trade plans, and proprietary indicators by Trend Edge.
About Centessa Pharmaceuticals PLC ADR
Centessa Pharmaceuticals plc, together with its subsidiaries, discovers, develops, and delivers orexin-based neuroscience therapeutics in the United Kingdom and the United States. The company develops ORX750, an orexin receptor 2 agonist, which is in Phase IIa clinical trial for the treatment of central disorders of hypersomnolence, including narcolepsy type 1 and 2, as well as idiopathic hypersomnia. Read full Trend Edge analysis →
Sector: Healthcare
Industry: Biotechnology
Exchange: NASDAQ
IPO Date: May 28, 2021
Headquarters: 1 Ashley Road, Altrincham, United Kingdom, WA14 2DT
Hidden Gem: Yes — undiscovered relative to its market cap tier
Founder-Led: No
Key Metrics
Current Price
$39.77
Market Cap
$6.16B
Float
92.5M
Shares Outstanding
154.7M
Price/Sales (TTM)
409.21
vs. Analyst Target
+12.1% to analyst PT
Dividend Rate
None
Analyst Target Price
$44.57 (11 analysts)
Financial History
Annual Revenue & Earnings History
Year
Revenue
Net Income
Gross Profit
EBITDA
2020
N/A
-$10.7M
N/A
-$10.3M
2021
N/A
-$382M
-$33,995
-$139M
2022
N/A
-$216M
-$131,000
-$210M
2023
$6.9M
-$151M
$6.9M
-$165M
2024
N/A
-$236M
-$942,396
-$222M
2025
$15.0M
-$198M
$15.0M
-$208M
Recent Quarterly Revenue & Net Income
Quarter
Revenue
Net Income
Jun 2025
N/A
-$50.3M
Sep 2025
N/A
-$54.9M
Dec 2025
N/A
-$66.2M
Mar 2026
N/A
-$79.2M
Ownership & Float
Insider Ownership
0.5%
Institutional Ownership
99.8%
Short Float
3.0%
% of All Funds Holding
1.83%
Number of Funds Holding
150
Current Moving Averages
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
Timeframe
SMA
Value
Trend Context
Weekly
10-Week SMA
$38.53
Near-term / short-term trend
Weekly
40-Week SMA
$27.84
Medium-term trend
Weekly
80-Week SMA
$21.55
Cyclical trend (business cycle)
Weekly
200-Week SMA
$13.11
Secular trend (multi-year)
Monthly
10-Month SMA
$29.03
Near-term monthly trend
Monthly
20-Month SMA
$22.22
Medium-term monthly trend
Monthly
40-Month SMA
$15.16
Secular monthly trend
Volume Shelves — Support & Resistance
Trend Edge identifies volume shelves: price zones where historically elevated trading volume
creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative
volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
Price Level
Type
Volume Ratio
Age
$26.70
support
2.38x
1 months ago
$16.80
support
1.54x
7 months ago
$13.10
support
1.35x
9 months ago
$10.60
support
1.47x
20 months ago
$9.00
support
1.08x
21 months ago
Historical Earnings Reactions (21 events)
Timeframe
Avg Return
Median
Win Rate
Best
Worst
Gap
0.83%
0.77%
61.90%
3.85%
-2.11%
1 Day
1.42%
0.18%
57.14%
14.44%
-9.89%
1 Week
0.56%
0.97%
55.00%
34.93%
-20.44%
2 Weeks
2.57%
2.49%
60.00%
34.59%
-35.60%
1 Month
5.36%
0.56%
50.00%
49.50%
-17.08%
Next earnings: May 18, 2026
Seasonality & Day-of-Week Patterns
Monthly Seasonality
Insufficient historical data for monthly seasonality analysis (requires 7+ years of data).
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The analysis covers five layers:
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qualitative analysis (business model, competitive moat, sector dynamics),
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