XERS — Xeris Pharmaceuticals Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates XERS Bullish with a Setup Score of 35, net conviction 52, actionability 24. How the Setup Score works →

Total Setup Score35
Directional BiasBullish
Net Conviction52
Actionability24 (in range)

Key signals behind this score

About Xeris Pharmaceuticals Inc

Xeris Biopharma Holdings, Inc., a commercial-stage biopharmaceutical company, engages in developing and commercializing therapies for chronic endocrine and neurological diseases in Illinois. It offers Gvoke, a ready-to-use liquid-stable glucagon for the treatment of severe hypoglycemia in pediatric and adult patients; Keveyis, a therapy for the treatment of hyperkalemic, hypokalemic, and related variants of primary periodic paralysis; and Recorle… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$8.74
Market Cap$1.57B
Float176.0M
Shares Outstanding182.3M
P/E (Forward)99.01
Price/Sales (TTM)4.67
vs. Analyst Target+34.0% to analyst PT
Profit Margin-5.12%
Operating Margin (TTM)5.62%
Revenue (TTM)$335M
Dividend RateNone
Analyst Target Price$11.71 (6 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $2.7M -$126M $1.1M -$118M
2021 $49.6M -$123M $36.3M -$114M
2022 $110M -$94.7M $87.6M -$69.3M
2023 $164M -$62.3M $135M -$23.7M
2024 $203M -$54.8M $166M -$14.0M
2025 $292M $554,000 $238M $12.7M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Sep 2025 $74.4M $621,000
Dec 2025 $85.8M $11.1M
Mar 2026 $83.1M $2.2M
Jun 2026 $92.1M -$31.1M

Ownership & Float

Insider Ownership3.1%
Institutional Ownership59.9%
Short Float5.2%
% of All Funds Holding2.69%
Number of Funds Holding237

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$8.35Near-term / short-term trend
Weekly40-Week SMA$7.02Medium-term trend
Weekly80-Week SMA$6.51Cyclical trend (business cycle)
Weekly200-Week SMA$3.99Secular trend (multi-year)
Monthly10-Month SMA$7.13Near-term monthly trend
Monthly20-Month SMA$6.46Medium-term monthly trend
Monthly40-Month SMA$4.48Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$6.20 support 1.01x 1 months ago
$9.70 resistance 1.04x 8 months ago
$5.10 support 1.48x 11 months ago
$3.90 support 2.42x 16 months ago

Historical Earnings Reactions (34 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.40% -0.17% 47.06% 9.91% -16.84%
1 Day -0.37% -1.92% 47.06% 12.40% -12.98%
1 Week 3.13% -1.98% 44.12% 50.83% -25.87%
2 Weeks 2.91% -2.43% 41.18% 87.19% -21.40%
1 Month 4.90% 1.14% 57.58% 114.05% -24.95%

Next earnings: October 25, 2026 (61 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan-7.0%37.5%8
Feb-3.1%62.5%8
Mar-3.3%50.0%8
Apr3.4%50.0%8
May15.1%75.0%8
Jun-2.4%50.0%8
Jul-0.6%55.6%9
Aug20.8%62.5%8
Sep-6.4%37.5%8
Oct-0.4%50.0%8
Nov-2.5%50.0%8
Dec5.2%62.5%8

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.09% 45.1% 386
Tuesday 0.05% 48.9% 423
Wednesday -0.08% 45.8% 419
Thursday -0.03% 45.6% 412
Friday 0.39% 47.1% 412

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 59.9%

Insider Transactions — Smart Summary

Total insider ownership: 3.1%

12-Month Insider Activity Summary

Total Filings26
Net Value-$3.9M
Net Shares Change-386,362
% of Float-0.2%
C-Suite Filings17
Clusters Detected4

Key Insiders

NameTitleNet ValueFilingsActivity
JOHNSON JOHN -$977,019.32 1 1 sell
McCulloch Kevin President and Chief Operating Officer -$722,511 1 N/A
Pieper Steven Chief Financial Officer -$383,175 1 N/A
PERSKY MARLA -$211,043.35 2 N/A
BORMANN-KENNEDY BARBARA-JEAN ANNE -$203,921.7 2 N/A
HALKUFF DAWN -$121,886 1 N/A
Brady James Aloysius -$60,035.528 1 N/A
SHERMAN JEFFREY W -$21,229.049 1 1 sell

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-01-05 – 2026-01-09 3 3 -$270,034.33 3 C-suite
2026-06-02 – 2026-06-05 5 5 -$503,230.17 1 C-suite
2026-07-02 – 2026-07-07 3 3 -$1.2M 3 C-suite
2026-08-04 – 2026-08-12 3 3 -$296,292.991 3 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2025-12-19 JOHNSON JOHN -$977,019.32 Transaction at $7.22, now +21.1%
2025-08-29 SHERMAN JEFFREY W -$21,229.049 Transaction at $7.29, now +19.9%
2026-06-05 PERSKY MARLA -$91,432.95 Transaction at $5.90, now +48.2%
2026-06-05 BORMANN-KENNEDY BARBARA-JEAN ANNE -$97,507.2 Transaction at $6.09, now +43.4%
2026-04-01 Brady James Aloysius -$60,035.528 Transaction at $5.54, now +57.7%
2026-07-07 Pieper Steven Chief Financial Officer -$383,175 Transaction at $8.52, now +2.6%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Xeris Pharmaceuticals Inc (XERS) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for XERS on Trend Edge →