XERS — Xeris Pharmaceuticals Inc

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

About Xeris Pharmaceuticals Inc

Xeris Biopharma Holdings, Inc., a commercial-stage biopharmaceutical company, engages in developing and commercializing therapies for chronic endocrine and neurological diseases in Illinois. It offers Gvoke, a ready-to-use liquid-stable glucagon for the treatment of severe hypoglycemia in pediatric and adult patients; Keveyis, a therapy for the treatment of hyperkalemic, hypokalemic, and related variants of primary periodic paralysis; and Recorle… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$6.26
Market Cap$1.08B
Float163.8M
Shares Outstanding172.6M
P/E (Forward)74.07
P/E (TTM)89.00
Price/Sales (TTM)3.42
vs. Analyst Target+80.3% to analyst PT
Profit Margin3.81%
Operating Margin (TTM)9.52%
Revenue (TTM)$315M
Dividend RateNone
Analyst Target Price$11.29 (6 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $2.7M -$126M $1.1M -$118M
2021 $49.6M -$123M $36.3M -$114M
2022 $110M -$94.7M $87.6M -$69.3M
2023 $164M -$62.3M $135M -$23.7M
2024 $203M -$54.8M $166M -$14.0M
2025 $292M $554,000 $238M $12.7M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 $71.5M -$1.9M
Sep 2025 $74.4M $621,000
Dec 2025 $85.8M $11.1M
Mar 2026 $83.1M $2.2M

Ownership & Float

Insider Ownership3.3%
Institutional Ownership62.3%
Short Float9.7%
% of All Funds Holding2.56%
Number of Funds Holding210

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$6.12Near-term / short-term trend
Weekly40-Week SMA$7.06Medium-term trend
Weekly80-Week SMA$5.78Cyclical trend (business cycle)
Weekly200-Week SMA$3.58Secular trend (multi-year)
Monthly10-Month SMA$7.24Near-term monthly trend
Monthly20-Month SMA$5.72Medium-term monthly trend
Monthly40-Month SMA$3.99Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$9.70 resistance 1.04x 5 months ago
$5.10 support 1.48x 8 months ago
$3.90 support 2.42x 13 months ago

Historical Earnings Reactions (33 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -0.44% -0.34% 45.45% 9.91% -16.84%
1 Day -0.62% -2.33% 45.45% 12.40% -12.98%
1 Week 2.71% -2.21% 42.42% 50.83% -25.87%
2 Weeks 2.44% -2.70% 39.39% 87.19% -21.40%
1 Month 5.02% 1.02% 56.25% 114.05% -24.95%

Next earnings: July 26, 2026 (60 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan-7.0%37.5%8
Feb-3.1%62.5%8
Mar-3.3%50.0%8
Apr3.4%50.0%8
May17.2%71.4%7
Jun-6.8%42.9%7
Jul-1.0%50.0%8
Aug20.8%62.5%8
Sep-6.4%37.5%8
Oct-0.4%50.0%8
Nov-2.5%50.0%8
Dec5.2%62.5%8

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.10% 44.9% 374
Tuesday -0.02% 47.6% 410
Wednesday -0.09% 45.8% 406
Thursday -0.03% 45.4% 399
Friday 0.39% 46.9% 401

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 62.3%

Insider Transactions — Smart Summary

Total insider ownership: 3.3%

12-Month Insider Activity Summary

Total Filings18
Net Value-$2.1M
Net Shares Change-336,635
% of Float-0.2%
C-Suite Filings11
Clusters Detected1

Key Insiders

NameTitleNet ValueFilingsActivity
JOHNSON JOHN -$1.8M 2 2 sell
Hecht Beth Chief Legal Officer and Corporate Secretary -$1.4M 1 N/A
HALKUFF DAWN -$309,225.75 1 1 sell
PERSKY MARLA -$119,610.4 1 N/A
McCulloch Kevin President and Chief Operating Officer +$109,475 1 1 buy
BORMANN-KENNEDY BARBARA-JEAN ANNE -$106,414.5 1 N/A
Brady James Aloysius -$60,035.528 1 N/A
Shannon John Patrick Jr Chief Executive Officer and Director -$26,258.521 1 N/A

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-01-05 – 2026-01-09 3 3 -$270,034.33 3 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2025-06-16 McCulloch Kevin President and Chief Operating Officer +$109,475 Transaction at $4.38, now +43.0%
2025-12-19 JOHNSON JOHN -$977,019.32 Transaction at $7.22, now -13.2%
2025-08-15 JOHNSON JOHN -$786,459.25 Transaction at $7.32, now -14.4%
2025-08-13 HALKUFF DAWN -$309,225.75 Transaction at $7.28, now -14.0%
2026-04-01 Brady James Aloysius -$60,035.528 Transaction at $5.54, now +13.0%
2025-08-29 SHERMAN JEFFREY W -$21,229.049 Transaction at $7.29, now -14.1%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Xeris Pharmaceuticals Inc (XERS) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for XERS on Trend Edge →