TLPH — Talphera Inc.

Stock analysis, trade plans, and proprietary indicators by Trend Edge.

Trend Edge Setup Score

Trend Edge rates TLPH Bullish with a Setup Score of 26, net conviction 30, actionability 22. How the Setup Score works →

Total Setup Score26
Directional BiasBullish
Net Conviction30
Actionability22 (in range)

Key signals behind this score

About Talphera Inc.

Talphera, Inc., a specialty pharmaceutical company, focuses on the development and commercialization of therapies for use in medically supervised settings. The company's lead product candidate, Niyad, is a lyophilized formulation of nafamostat that acts as a regional anticoagulant for infusion into the extracorporeal circuit. It is also developing LTX-608, a lyophilized vial containing nafamostat for IV infusion for disseminated intravascular coa… Read full Trend Edge analysis →

Trend Edge Proprietary Indicators

Key Metrics

Current Price$1.41
Market Cap$74.2M
Float27.0M
Shares Outstanding51.9M
P/E (Forward)1.02
Price/Sales (TTM)74,216.49
vs. Analyst Target+124.6% to analyst PT
Operating Margin (TTM)-1451600.00%
Revenue (TTM)$1,000
Dividend RateNone
Analyst Target Price$3.17 (2 analysts)

Financial History

Annual Revenue & Earnings History

YearRevenueNet IncomeGross ProfitEBITDA
2020 $5.4M -$40.4M -$616,000 -$35.2M
2021 $378,000 -$35.1M -$2.6M -$12.9M
2022 $1.8M $42.5M -$1.6M $61.9M
2023 $651,000 -$18.4M -$4.9M -$10.1M
2024 N/A -$13.0M -$6.7M -$12.5M
2025 $28,000 -$14.3M $28,000 -$14.4M

Recent Quarterly Revenue & Net Income

QuarterRevenueNet Income
Jun 2025 N/A -$3.5M
Sep 2025 $1,000 -$4.4M
Dec 2025 N/A -$3.8M
Mar 2026 N/A -$2.6M

Ownership & Float

Insider Ownership21.4%
Institutional Ownership34.8%
Short Float3.3%

Current Moving Averages

Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.

TimeframeSMAValueTrend Context
Weekly10-Week SMA$1.23Near-term / short-term trend
Weekly40-Week SMA$1.02Medium-term trend
Weekly80-Week SMA$0.83Cyclical trend (business cycle)
Weekly200-Week SMA$0.99Secular trend (multi-year)
Monthly10-Month SMA$1.05Near-term monthly trend
Monthly20-Month SMA$0.84Medium-term monthly trend
Monthly40-Month SMA$0.88Secular monthly trend

Volume Shelves — Support & Resistance

Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.

Price LevelTypeVolume RatioAge
$1.10 support 1.49x 0 months ago
$0.60 support 4.62x 10 months ago
$0.50 support 6.94x 11 months ago

Historical Earnings Reactions (62 events)

TimeframeAvg ReturnMedianWin RateBestWorst
Gap -2.44% -1.21% 25.81% 14.29% -28.33%
1 Day -3.69% -3.74% 30.65% 19.61% -27.62%
1 Week -2.16% -2.19% 41.94% 37.31% -32.29%
2 Weeks 1.92% -1.24% 43.55% 52.54% -36.46%
1 Month 2.15% -2.49% 45.16% 118.60% -44.95%

Next earnings: August 13, 2026 (1 days away)

Seasonality & Day-of-Week Patterns

Monthly Seasonality

MonthAvg ReturnWin RateSamples
Jan11.6%53.3%15
Feb0.1%40.0%15
Mar-11.6%37.5%16
Apr3.0%56.3%16
May4.9%37.5%16
Jun0.7%43.8%16
Jul3.4%37.5%16
Aug2.3%53.3%15
Sep1.2%46.7%15
Oct-4.7%40.0%15
Nov6.8%53.3%15
Dec-11.3%20.0%15

Day-of-Week Tendencies

DayAvg ReturnWin RateSamples
Monday 0.18% 43.9% 729
Tuesday -0.23% 37.5% 801
Wednesday 0.16% 42.7% 798
Thursday -0.06% 40.7% 784
Friday 0.18% 43.0% 781

Top Institutional Holders

Institutional holder breakdown coming soon.

Total institutional ownership: 34.8%

Insider Transactions — Smart Summary

Total insider ownership: 21.4%

12-Month Insider Activity Summary

Total Filings5
Net Value+$288,116.316
Net Shares Change413,918
% of Float1.5%
C-Suite Filings5
Clusters Detected1

Key Insiders

NameTitleNet ValueFilingsActivity
Angotti Vincent J. CHIEF EXECUTIVE OFFICER +$200,344.211 2 2 buy
ASADORIAN RAFFI Chief Financial Officer +$33,425.525 1 1 buy
Aslam Shakil Chief Medical Officer +$28,430.5 1 1 buy
Dasu Badri N Chief Engineering Officer +$25,916.079 1 1 buy

Transaction Clusters

PeriodFilingsInsidersNet ValueSeniority
2026-02-20 – 2026-02-20 4 4 +$163,116.656 4 C-suite

Significant Filings

DateInsiderTitleNet ValuePrice After
2026-03-25 Angotti Vincent J. CHIEF EXECUTIVE OFFICER +$124,999.66 Transaction at $0.59, now +140.6%
2026-02-20 Dasu Badri N Chief Engineering Officer +$25,916.079 Transaction at $0.81, now +74.5%
2026-02-20 Aslam Shakil Chief Medical Officer +$28,430.5 Transaction at $0.81, now +73.6%
2026-02-20 Angotti Vincent J. CHIEF EXECUTIVE OFFICER +$75,344.551 Transaction at $0.81, now +74.5%
2026-02-20 ASADORIAN RAFFI Chief Financial Officer +$33,425.525 Transaction at $0.81, now +74.5%

View full insider transaction history on Trend Edge →

AI Consult Analysis

Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Talphera Inc. (TLPH) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).

AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.

Get the full AI Consult analysis for TLPH on Trend Edge →