Stock analysis, trade plans, and proprietary indicators by Trend Edge.
Trend Edge rates AMLX Bullish with a Setup Score of 0, net conviction 32, actionability 0. How the Setup Score works →
| Total Setup Score | 0 |
|---|---|
| Directional Bias | Bullish |
| Net Conviction | 32 |
| Actionability | 0 (extended) |
Amylyx Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, engages in the discovery and development of treatment options for neurodegenerative diseases and endocrine conditions in the United States. It provides Avexitide, an investigational, first-in-class glucagon-like peptide-1, or GLP-1 receptor antagonist, which is in phase 3 clinical trial to treat post-bariatric hypoglycemia and congenital hyperinsulinism. Read full Trend Edge analysis →
| Current Price | $38.15 |
|---|---|
| Market Cap | $4.55B |
| Float | 82.6M |
| Shares Outstanding | 111.4M |
| P/E (Forward) | 2.77 |
| Price/Sales (TTM) | 0.66 |
| vs. Analyst Target | +10.6% to analyst PT |
| Revenue (TTM) | -$665,000 |
| Dividend Rate | None |
| Analyst Target Price | $42.18 (7 analysts) |
| Year | Revenue | Net Income | Gross Profit | EBITDA |
|---|---|---|---|---|
| 2020 | $650,000 | -$42.3M | -$23.9M | -$39.0M |
| 2021 | $285,000 | -$87.9M | $285,000 | -$82.6M |
| 2022 | $22.2M | -$198M | $19.2M | -$201M |
| 2023 | $381M | $49.3M | $355M | $55.4M |
| 2024 | $87.4M | -$302M | $45.2M | -$291M |
| 2025 | N/A | -$145M | -$525,000 | -$144M |
| Quarter | Revenue | Net Income |
|---|---|---|
| Sep 2025 | N/A | -$34.4M |
| Dec 2025 | N/A | -$33.0M |
| Mar 2026 | N/A | -$41.3M |
| Jun 2026 | N/A | -$43.4M |
| Insider Ownership | 7.0% |
|---|---|
| Institutional Ownership | 93.8% |
| Short Float | 16.2% |
| % of All Funds Holding | 2.35% |
| Number of Funds Holding | 207 |
Trend Edge tracks near-term, medium-term, cyclical, and secular moving averages across weekly and monthly timeframes to identify trend structure at every horizon.
| Timeframe | SMA | Value | Trend Context |
|---|---|---|---|
| Weekly | 10-Week SMA | $23.16 | Near-term / short-term trend |
| Weekly | 40-Week SMA | $16.52 | Medium-term trend |
| Weekly | 80-Week SMA | $12.23 | Cyclical trend (business cycle) |
| Weekly | 200-Week SMA | $14.34 | Secular trend (multi-year) |
| Monthly | 10-Month SMA | $17.72 | Near-term monthly trend |
| Monthly | 20-Month SMA | $12.46 | Medium-term monthly trend |
| Monthly | 40-Month SMA | $11.73 | Secular monthly trend |
Trend Edge identifies volume shelves: price zones where historically elevated trading volume creates structural support or resistance. A volume shelf forms when a disproportionate share of cumulative volume was transacted at a specific price level, making it a high-conviction anchor for future price reactions.
| Price Level | Type | Volume Ratio | Age |
|---|---|---|---|
| $20.30 | support | 2.11x | 0 months ago |
| $14.10 | support | 1.26x | 1 months ago |
| $9.20 | support | 1.83x | 10 months ago |
| $6.40 | support | 1.42x | 12 months ago |
| $5.20 | support | 1.49x | 13 months ago |
| Timeframe | Avg Return | Median | Win Rate | Best | Worst |
|---|---|---|---|---|---|
| Gap | 0.44% | 0.00% | 42.11% | 19.31% | -21.77% |
| 1 Day | 0.17% | -1.20% | 47.37% | 12.97% | -13.93% |
| 1 Week | 0.05% | -1.55% | 42.11% | 29.90% | -27.22% |
| 2 Weeks | 1.50% | 3.21% | 57.89% | 59.82% | -81.88% |
| 1 Month | 5.47% | 4.55% | 55.56% | 110.96% | -85.22% |
Next earnings: October 25, 2026 (61 days away)
Insufficient historical data for monthly seasonality analysis (requires 7+ years of data).
| Day | Avg Return | Win Rate | Samples |
|---|---|---|---|
| Monday | -0.07% | 47.9% | 215 |
| Tuesday | 0.62% | 50.0% | 240 |
| Wednesday | 0.79% | 54.2% | 238 |
| Thursday | 0.14% | 50.0% | 232 |
| Friday | -0.09% | 49.8% | 233 |
Institutional holder breakdown coming soon.
Total institutional ownership: 93.8%
Total insider ownership: 7.0%
Founder-led management: Joshua Cohen (Co-Founder, Co-CEO & Director), Justin Klee (Co-Founder, Co-CEO & Director)
| Total Filings | 24 |
|---|---|
| Net Value | -$4.7M |
| Net Shares Change | -132,326 |
| % of Float | -0.2% |
| C-Suite Filings | 22 |
| Clusters Detected | 4 |
| Name | Title | Net Value | Filings | Activity |
|---|---|---|---|---|
| Mazzariello Gina | Chief Legal Officer | -$766,913.285 | 3 | 2 sell |
| Cohen Joshua B | Co-Chief Executive Officer | -$424,120.488 | 1 | 1 sell |
| Klee Justin B. | Co-Chief Executive Officer | -$423,760.319 | 1 | 1 sell |
| Bedrosian Camille L | Chief Medical Officer | -$269,723.042 | 2 | 2 sell |
| Firestone Karen | +$152,183 | 2 | 2 buy | |
| FRATES JAMES M | Chief Financial Officer | -$114,851.334 | 1 | 1 sell |
| Period | Filings | Insiders | Net Value | Seniority |
|---|---|---|---|---|
| 2025-10-02 – 2025-10-02 | 5 | 5 | -$1.3M | 5 C-suite |
| 2026-01-08 – 2026-01-20 | 5 | 3 | -$935,804.065 | 5 C-suite |
| 2026-02-04 – 2026-02-04 | 4 | 4 | -$557,822.703 | 4 C-suite |
| 2026-02-25 – 2026-03-04 | 6 | 5 | -$1.2M | 6 C-suite |
| Date | Insider | Title | Net Value | Price After |
|---|---|---|---|---|
| 2026-05-26 | Firestone Karen | +$51,338 | Transaction at $13.51, now +182.4% | |
| 2025-12-23 | Firestone Karen | +$100,845 | Transaction at $12.45, now +206.4% | |
| 2026-03-04 | Mazzariello Gina | Chief Legal Officer | -$99,378.302 | Transaction at $14.52, now +162.7% |
| 2026-03-04 | FRATES JAMES M | Chief Financial Officer | -$114,851.334 | Transaction at $14.52, now +162.7% |
| 2026-03-04 | Bedrosian Camille L | Chief Medical Officer | -$94,205.257 | Transaction at $14.58, now +161.6% |
| 2026-03-04 | Klee Justin B. | Co-Chief Executive Officer | -$423,760.319 | Transaction at $14.47, now +163.6% |
Trend Edge's AI Consult feature delivers a comprehensive, multi-layer trade plan for Amylyx Pharmaceuticals Inc (AMLX) powered by Claude Opus — Anthropic's most capable AI model. The analysis covers five layers: technical analysis (near-term, medium-term, cyclical, and secular trend, momentum, volume shelf support and resistance, breakout and breakdown signals), qualitative analysis (business model, competitive moat, sector dynamics), insider sentiment (buy and sell signals from executive and director transactions), share stats analysis (institutional accumulation, fund positioning, short float squeeze potential), and fundamental analysis (valuation, revenue growth, profit margin, earnings quality).
AI Consult synthesizes all five layers into a single bullish or bearish thesis with explicit entry, exit, stop loss, and take profit levels — giving you a complete, AI-powered trade plan with defined risk/reward. Whether you are building a long position, initiating a short, or looking for a reversal setup, AI Consult identifies the highest-probability signal from the current trend.
Get the full AI Consult analysis for AMLX on Trend Edge →